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Incidence and time trends of childhood lymphomas: findings from 14 Southern and Eastern European cancer registries and the Surveillance, Epidemiology and End Results, USA

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Abstract

Purpose

To describe epidemiologic patterns of childhood (0–14 years) lymphomas in the Southern and Eastern European (SEE) region in comparison with the Surveillance, Epidemiology and End Results (SEER), USA, and explore tentative discrepancies.

Methods

Childhood lymphomas were retrieved from 14 SEE registries (n = 4,702) and SEER (n = 4,416), diagnosed during 1990–2014; incidence rates were estimated and time trends were evaluated.

Results

Overall age-adjusted incidence rate was higher in SEE (16.9/106) compared to SEER (13.6/106), because of a higher incidence of Hodgkin (HL, 7.5/106 vs. 5.1/106) and Burkitt lymphoma (BL, 3.1 vs. 2.3/106), whereas the incidence of non-Hodgkin lymphoma (NHL) was overall identical (5.9/106 vs. 5.8/106), albeit variable among SEE. Incidence increased with age, except for BL which peaked at 4 years; HL in SEE also showed an early male-specific peak at 4 years. The male preponderance was more pronounced for BL and attenuated with increasing age for HL. Increasing trends were noted in SEER for total lymphomas and NHL, and was marginal for HL, as contrasted to the decreasing HL and NHL trends generally observed in SEE registries, with the exception of increasing HL incidence in Portugal; of note, BL incidence trend followed a male-specific increasing trend in SEE.

Conclusions

Registry-based data reveal variable patterns and time trends of childhood lymphomas in SEE and SEER during the last decades, possibly reflecting diverse levels of socioeconomic development of the populations in the respective areas; optimization of registration process may allow further exploration of molecular characteristics of disease subtypes.

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Acknowledgments

Contributions are acknowledged to the Surveillance, Epidemiology and End Results (SEER) officials for their kind responsiveness. Special thanks are also due to cancer registry personnel for their contribution to registry data processes. We would like to acknowledge the contribution of Nick Dessypris for handling the SEER data and contributing to the statistical analysis.

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Authors and Affiliations

  1. Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias Str, 11527, Athens, Greece

    Marios K. Georgakis, Maria A. Karalexi, Evdoxia Bouka, Prodromos Kanavidis, Μaria Kantzanou & Eleni Th. Petridou

  2. Department of Health Information and Research, Malta National Cancer Registry, Pieta, Malta

    Domenic Agius

  3. North Region Cancer Registry of Portugal (RORENO), Portuguese Oncology Institute of Porto, Porto, Portugal

    Luis Antunes

  4. Central Region Cancer Registry of Portugal (ROR-Centro), Portuguese Oncology Institute of Coimbra, Coimbra, Portugal

    Joana Bastos

  5. Regional Cancer Registry of Cluj, Oncological Institute “Ion Chiricuta”, Cluj-Napoca, Romania

    Daniela Coza

  6. Cyprus Cancer Registry-Health Monitoring Unit, Ministry of Health, Nicosia, Cyprus

    Anna Demetriou

  7. Bulgarian National Cancer Registry, National Oncology Hospital, Sofia, Bulgaria

    Nadya Dimitrova

  8. Izmir Cancer Registry, Izmir Hub, Izmir and Hacettepe University Institute of Public Health, Ankara, Turkey

    Sultan Eser

  9. Regional Cancer Registry of Iaşi, National Institute of Public Health, Iaşi, Romania

    Margareta Florea

  10. National Cancer Registry of Ukraine, National Institute of Cancer, Kiev, Ukraine

    Anton Ryzhov

  11. Croatian National Cancer Registry, Croatian Institute of Public Health, Zagreb, Croatia

    Mario Sekerija

  12. Cancer Registry of Republic of Slovenia, Institute of Oncology, Ljubljana, Slovenia

    Tina Žagar

  13. Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Childhood Cancer Subregistry of Belarus, Minsk, Belarus

    Anna Zborovskaya

  14. Institute of Public Health of Serbia, Belgrade, Serbia

    Snezana Zivkovic

  15. Oncology Department, Mitera Childrens Hospital, Athens, Greece

    Helen Dana

  16. Second Department of Pediatrics, AHEPA General Hospital, Aristotelion University of Thessaloniki, Thessaloníki, Greece

    Emmanuel Hatzipantelis

  17. Department of Pediatric Hematology and Oncology, Hippokration Hospital, Thessaloníki, Greece

    Maria Kourti

  18. Haematology-Oncology Unit, First Department of Pediatrics, “Aghia Sophia” Children’s Hospital, Athens University Medical School, Athens, Greece

    Maria Moschovi

  19. Department of Pediatric Haematology-Oncology, “Aghia Sophia” Children’s Hospital, Athens, Greece

    Sophia Polychronopoulou

  20. Department of Pediatric Hematology-Oncology, University Hospital of Heraklion, University of Crete, Heraklion, Greece

    Eftichia Stiakaki

  21. Department of Pediatric Hematology-Oncology, “Pan. & Agl. Kyriakou” Children’s Hospital, Athens, Greece

    Apostolos Pourtsidis

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  1. Marios K. Georgakis
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  2. Maria A. Karalexi
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  3. Domenic Agius
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  4. Luis Antunes
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  26. Eleni Th. Petridou
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Correspondence to Eleni Th. Petridou.

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Georgakis, M.K., Karalexi, M.A., Agius, D. et al. Incidence and time trends of childhood lymphomas: findings from 14 Southern and Eastern European cancer registries and the Surveillance, Epidemiology and End Results, USA. Cancer Causes Control 27, 1381–1394 (2016). https://doi.org/10.1007/s10552-016-0817-3

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