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Effect on HPV vaccination in Japan resulting from news report of adverse events and suspension of governmental recommendation for HPV vaccination

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International Journal of Clinical Oncology Aims and scope Submit manuscript

Abstract

Background

Administration of the human papillomavirus (HPV) vaccine decreased dramatically in Japan after extensive news of adverse vaccine events and suspension of the governmental recommendation for the vaccine. In this study, we investigated the knowledge and acceptance of vaccinated adolescents concerning cervical cancer, cancer screening and the HPV vaccine. Furthermore, we analyzed whether and by how much the news affected acceptance of the vaccination.

Methods

This study was conducted as a part of Osaka Clinical resEArch of HPV vacciNe (OCEAN) study. A questionnaire was distributed to 2,777 study registrants.

Results

The response rate was 38 %. The recognition rate of the news of the vaccine’s adverse events was 80 %; it was 68 % for awareness of the government’s announcement of the suspension of its recommendation for the vaccine. Among those who had a chance to hear or see the negative news during their vaccination period, 46 (60 %) continued vaccination while knowing of the news, 22 (29 %) discontinued vaccination, and 9 (11 %) continued vaccination without an awareness of the news. Reports of the vaccine’s adverse events were the main reason for not continuing the vaccination series. Those who consulted doctors after hearing the adverse news were significantly more likely to continue their vaccinations than those who did not.

Conclusions

Our results should help in understanding the need for a strong promotion of vaccine usage and cancer screening after future retraction of the recommendation suspension. This may apply to other countries with an unsatisfactory rate of HPV vaccination due to fears of adverse vaccine events.

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Acknowledgments

We would like to thank Dr. G. S. Buzard, BAH, for his constructive critique and editing of our manuscript. We also thank all the doctors who registered relevant cases in the OCEAN study, and all the registrants of the OCEAN study who responded to our questionnaire. We deeply appreciate Dr. Osamu Ishiko, Dr. Hiroshi Hoshiai, Dr. Yoh Watanabe, Ms. Emi Hatano, Ms. Kanako Sakiyama, Ms. Ayaka Tanaka, Ms. Yohimi Tomine, Mr. Jun Fukuyoshi, several medical students of the Osaka University and the Executive Office of the Obstetrical Gynecological Society of Osaka for their great support for the OCEAN study.

Conflict of interest

The present study was financially supported in part by Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare, Japan.

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Authors and Affiliations

  1. The Obstetrical Gynecological Society of Osaka, 4-4-3 Kawaramachi, Chuo-ku, Osaka, 541-0048, Japan

    Akiko Morimoto, Yutaka Ueda, Tomomi Egawa-Takata, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hideharu Kanzaki, Hidekatsu Nakai, Masaki Mandai, Kiyoshi Yoshino, Masami Fujita, Tadashi Kimura, Junko Saito, Takayuki Enomoto, Yorihiko Horikoshi & Tetsu Takagi

  2. Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan

    Akiko Morimoto, Yutaka Ueda, Tomomi Egawa-Takata, Asami Yagi, Kiyoshi Yoshino, Masami Fujita & Tadashi Kimura

  3. Department of Obstetrics and Gynecology, Osaka Medical College Graduate School of Medical Sciences, 2-7 Daigakumachi, Takatsuki, Osaka, 569-8686, Japan

    Yoshito Terai & Masahide Ohmichi

  4. Department of Obstetrics and Gynecology, Osaka City University Graduate School and Faculty of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan

    Tomoyuki Ichimura & Toshiyuki Sumi

  5. Department of Obstetrics and Gynecology, Kansai Medical University Graduate School of Medicine, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan

    Hiromi Murata & Hideharu Kanzaki

  6. Department of Obstetrics and Gynecology, Kinki University Graduate School of Medical Sciences, 377-2 Ono- Higashi, Osaka-Sayama, Osaka, 589-8511, Japan

    Hidekatsu Nakai & Masaki Mandai

  7. Saito Women’s Clinic, 1-6-1 Miyahara, Yodogawa-ku, Osaka, 532-0003, Japan

    Junko Saito

  8. Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan

    Tomotaka Sobue

  9. Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan

    Nobumichi Nishikawa, Masayuki Sekine & Takayuki Enomoto

Authors
  1. Akiko Morimoto
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  2. Yutaka Ueda
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  3. Tomomi Egawa-Takata
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  4. Asami Yagi
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  5. Yoshito Terai
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  6. Masahide Ohmichi
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  7. Tomoyuki Ichimura
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  8. Toshiyuki Sumi
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  9. Hiromi Murata
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  10. Hideharu Kanzaki
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  11. Hidekatsu Nakai
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  12. Masaki Mandai
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  13. Kiyoshi Yoshino
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  14. Masami Fujita
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  15. Tadashi Kimura
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  16. Junko Saito
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  17. Tomotaka Sobue
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  18. Nobumichi Nishikawa
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  19. Masayuki Sekine
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  20. Takayuki Enomoto
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  21. Yorihiko Horikoshi
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  22. Tetsu Takagi
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Corresponding author

Correspondence to Yutaka Ueda.

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Morimoto, A., Ueda, Y., Egawa-Takata, T. et al. Effect on HPV vaccination in Japan resulting from news report of adverse events and suspension of governmental recommendation for HPV vaccination. Int J Clin Oncol 20, 549–555 (2015). https://doi.org/10.1007/s10147-014-0723-1

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  • DOI: https://doi.org/10.1007/s10147-014-0723-1

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