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Effect of low-level laser therapy on inflammatory mediator release during chemotherapy-induced oral mucositis: a randomized preliminary study

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Abstract

Patients undergoing hematopoietic stem cell transplantation (HSCT) are submitted to a conditioning regimen of high-dose chemotherapy, with or without radiation therapy, which usually results in oral ulcerations and mucosal barrier breakdown. Oral mucositis (OM) is a common and debilitating toxicity side effect of autologous and allogeneic HSCT. The aim of this study was to evaluate the effect of low-level laser therapy (LLLT) on the severity of OM and inflammatory mediator (TNF-α, IL-6, IL-1β, IL-10, TGF-β, metalloproteinases, and growth factors) levels in saliva and blood of HSCT patients. Thirty patients were randomly assigned to two groups: control (n = 15) and laser (n = 15). LLLT was applied from the first day of the conditioning regimen until day 7 post-HSCT (D + 7). Saliva and blood were collected from patients on admission (AD), D-1, D + 3, D + 7, and on marrow engraftment day (ME). Clinical results showed less severe OM in the laser group (p < 0.05). The LLLT group showed increased matrix metalloproteinase 2 (MMP-2) levels in saliva on D + 7 (p = 0.04). Significant differences were also observed for IL-10 on D + 7 and on ME in blood plasma, when compared to the control group (p < 0.05). No significant differences were seen in saliva or blood for the other inflammatory mediators investigated. LLLT was clinically effective in reducing the severity of chemotherapy-induced OM in HSCT patients, and its mechanism of action does not seem to be completely linked to the modulation of pro- or anti-inflammatory cytokines, growth factors or matrix metalloproteinases.

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Acknowledgments

This study was sponsored by grants from the Foundation for Research Support in the State of Goiás (FAPEG—Grant 2010102670007) and the National Council for Scientific and Technological Development (CNPq—Grant 479587/2010-8). The authors wish to thank Araújo Jorge Hospital, Goiás Cancer Combat Association, Goiânia, Brazil.

Conflict of interest

None declared.

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Authors and Affiliations

  1. Hematopoietic Stem Cell Transplant Unit, Araújo Jorge Hospital, Associação de Combate ao Câncer de Goiás, Goiânia, Goiás, Brazil

    Geisa Badauy Lauria Silva, Adriano Moraes Arantes, César Bariani & Luciana Garcia Lobo Duarte

  2. Department of Stomatology (Oral Pathology), Dental School, Federal University of Goiás, Goiânia, Goiás, Brazil

    Geisa Badauy Lauria Silva, Nancy Tomoko Sacono, Angélica Ferreira Othon-Leite, Elismauro Francisco Mendonça & Aline Carvalho Batista

  3. Department of Preventive and Social Dentistry, Dental School, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Mauro Henrique Nogueira Abreu

  4. Department of Oral Surgery and Pathology, Dental School, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Celso Martins Queiroz-Júnior & Tarcília Aparecida Silva

Authors
  1. Geisa Badauy Lauria Silva
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  2. Nancy Tomoko Sacono
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  4. Elismauro Francisco Mendonça
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  11. Aline Carvalho Batista
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Correspondence to Aline Carvalho Batista.

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Silva, G.B.L., Sacono, N.T., Othon-Leite, A.F. et al. Effect of low-level laser therapy on inflammatory mediator release during chemotherapy-induced oral mucositis: a randomized preliminary study. Lasers Med Sci 30, 117–126 (2015). https://doi.org/10.1007/s10103-014-1624-2

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  • DOI: https://doi.org/10.1007/s10103-014-1624-2

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