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Elevated fibrinogen levels in neuromyelitis optica is associated with severity of disease

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Abstract

Multiple sclerosis (MS) and neuromyelitis optica (NMO) are inflammatory demyelinating diseases of the central nervous system. In this study, the important role of fibrinogen in demyelination diseases was investigated. Plasma prothrombin time (PT), activated partial thrombin time (APTT), thrombin time (TT), fibrinogen, were measured among 189 patients with MS/NMO and 80 non-inflammatory neurological disease subjects as a control group. The Expanded Disability Status Scale (EDSS) was used to measure neurological impairment and disability of MS/NMO group. Fibrinogen levels were elevated in NMO and MS groups comparing with control ones, which was statistically associated with the severity of disease. Our results may lead to a better understanding of the etiopathogenesis of MS/NMO and contribute to prospects for preventions and treatments.

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Authors and Affiliations

  1. Department of Neurology, Nanfang Hospital, Guangzhou, Guangdong Province, China

    Ya Zhang, Xiaomei Zhang, Honghao Wang, Suyue Pan, Dongmei Wang & Xiong Chen

  2. Department of Neurology, GuangDong Province Hospital of Traditional Chinese Medicine Zhuhai Branch, Zhuhai, Guangdong Province, China

    Dongsheng Liu

Authors
  1. Ya Zhang
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  2. Xiaomei Zhang
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  3. Dongsheng Liu
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  4. Honghao Wang
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  5. Suyue Pan
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  6. Dongmei Wang
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  7. Xiong Chen
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Correspondence to Honghao Wang.

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We declared no conflict of interest regarding this study.

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Zhang, Y., Zhang, X., Liu, D. et al. Elevated fibrinogen levels in neuromyelitis optica is associated with severity of disease. Neurol Sci 37, 1823–1829 (2016). https://doi.org/10.1007/s10072-016-2628-4

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  • DOI: https://doi.org/10.1007/s10072-016-2628-4

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