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The aspartic acid metabolic pathway, an exciting and essential pathway in plants

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Summary.

Aspartate is the common precursor of the essential amino acids lysine, threonine, methionine and isoleucine in higher plants. In addition, aspartate may also be converted to asparagine, in a potentially competing reaction. The latest information on the properties of the enzymes involved in the pathways and the genes that encode them is described. An understanding of the overall regulatory control of the flux through the pathways is undisputedly of great interest, since the nutritive value of all cereal and legume crops is reduced due to low concentrations of at least one of the aspartate-derived amino acids. We have reviewed the recent literature and discussed in this paper possible methods by which the concentrations of the limiting amino acids may be increased in the seeds.

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References

  • H Aarnes SE Rognes (1974) ArticleTitleThreonine-sensitive aspartate kinase and homoserine dehydrogenase from Pisum sativum. Phytochemistry 13 2717–2724 Occurrence Handle10.1016/0031-9422(74)80229-3 Occurrence Handle1:CAS:528:DyaE2MXhtVyjsrs%3D

    Article  CAS  Google Scholar 

  • M Andrews PJ Lea JA Raven K Lindsey (2004) ArticleTitleCan genetic manipulation of plant nitrogen assimilation enzymes result in increased crop yield and greater N-use efficiency? An assessment. Ann Appl Biol 145 25–40 Occurrence Handle1:CAS:528:DC%2BD2cXnsFSjtrs%3D

    CAS  Google Scholar 

  • P Arruda EL Kemper F Papes A Leite (2000) ArticleTitleRegulation of lysine catabolism in higher plants. Trends Plant Sci 5 324–330 Occurrence Handle10.1016/S1360-1385(00)01688-5 Occurrence Handle1:STN:280:DC%2BD3cvhtFCksA%3D%3D Occurrence Handle10908876

    Article  CAS  PubMed  Google Scholar 

  • T Avraham H Badani S Galili R Amir (2005) ArticleTitleEnhanced levels of methionine and cysteine in transgenic alfalfa (Medicago sativa L.) plants overexpressing Arabidopsis cystathionine γ-synthase gene. Plant Biotechnol J 3 71–79 Occurrence Handle1:CAS:528:DC%2BD2MXhvFyqsLs%3D

    CAS  Google Scholar 

  • RA Azevedo (2002) ArticleTitleAnalysis of the aspartic acid metabolic pathway using mutant genes. Amino Acids 22 217–230 Occurrence Handle10.1007/s007260200010 Occurrence Handle1:CAS:528:DC%2BD38XkvFOmu78%3D Occurrence Handle12083066

    Article  CAS  PubMed  Google Scholar 

  • RA Azevedo PJ Lea (2001) ArticleTitleLysine metabolism in higher plants. Amino Acids 20 261–279 Occurrence Handle10.1007/s007260170043 Occurrence Handle1:CAS:528:DC%2BD3MXks1Gjsrg%3D Occurrence Handle11354603

    Article  CAS  PubMed  Google Scholar 

  • RA Azevedo JL Arana P Arruda (1990) ArticleTitleBiochemical genetics of the interaction of the lysine plus threonine resistant mutant Ltr* 19 with opaque-2 maize mutant. Plant Sci 70 81–90 Occurrence Handle10.1016/0168-9452(90)90035-M Occurrence Handle1:CAS:528:DyaK3cXmtVynurk%3D

    Article  CAS  Google Scholar 

  • RA Azevedo RJ Smith PJ Lea (1992a) ArticleTitleAspects of aspartate kinase regulation in maize: co-purification of aspartate kinase and homoserine dehydrogenase sensitive to threonine. Phytochemistry 31 3731–3734 Occurrence Handle1:CAS:528:DyaK3sXhvVegsQ%3D%3D

    CAS  Google Scholar 

  • RA Azevedo RD Blackwell RJ Smith PJ Lea (1992b) ArticleTitleThree aspartate kinase isoenzymes from maize. Phytochemistry 31 3725–3730 Occurrence Handle1:CAS:528:DyaK3sXhvVegsA%3D%3D

    CAS  Google Scholar 

  • RA Azevedo P Arruda WL Turner PJ Lea (1997) ArticleTitleThe biosynthesis and metabolism of the aspartate derived amino acids in higher plants. Phytochemistry 46 395–419 Occurrence Handle1:CAS:528:DyaK2sXms1Snt7g%3D Occurrence Handle9332022

    CAS  PubMed  Google Scholar 

  • RA Azevedo C Damerval J Landry PJ Lea CM Bellato LW Meinhardt M Le Guilloux S Delhaye AA Toro SA Gaziola DBA Berdejo (2003) ArticleTitleRegulation of maize lysine metabolism and endosperm protein synthesis by opaque and floury mutations. Eur J Biochem 270 4898–4908 Occurrence Handle10.1111/j.1432-1033.2003.03890.x Occurrence Handle1:CAS:528:DC%2BD2cXitVyh Occurrence Handle14653816

    Article  CAS  PubMed  Google Scholar 

  • RA Azevedo C Damerval PJ Lea J Landry CM Bellato LW Meinhardt M Le Guilloux S Delhaye AA Toro SA Gaziola VA Varisi PL Gratão (2004a) ArticleTitleEndosperm protein synthesis and lysine metabolism in distinct opaque maize seed mutants. Funct Plant Biol 31 339–348 Occurrence Handle10.1071/FP03173 Occurrence Handle1:CAS:528:DC%2BD2cXjs12murg%3D

    Article  CAS  Google Scholar 

  • RA Azevedo PJ Lea C Damerval J Landry CM Bellato LW Meinhardt M Le Guilloux S Delhaye VA Varisi SA Gaziola PL Gratão AA Toro (2004b) ArticleTitleRegulation of lysine metabolism and endosperm protein synthesis by the opaque-5 and opaque-7 maize mutations. J Agric Food Chem 52 4865–4871 Occurrence Handle10.1021/jf035422h Occurrence Handle1:CAS:528:DC%2BD2cXltlOkt7g%3D

    Article  CAS  Google Scholar 

  • D Bartlem I Lambein T Okamoto A Itaya Y Uda F Kijima Y Tamaki E Nambara S Naito (2000) ArticleTitleMutation in the threonine synthase gene results in an over-accumulation of soluble methionine in Arabidopsis. Plant Physiol 123 101–110 Occurrence Handle10.1104/pp.123.1.101 Occurrence Handle1:CAS:528:DC%2BD3cXjsFenu7k%3D Occurrence Handle10806229

    Article  CAS  PubMed  Google Scholar 

  • L Belbahri L Chevalier L Bensaddek F Gillet MA Fliniaux W Boerjan D Inze D Thomas B Thomasset (2000) ArticleTitleDifferent expression of an S-adenosylmethionine synthetase gene in transgenic tobacco callus modifies alkaloid biosynthesis. Biotechnol Bioeng 69 11–20 Occurrence Handle10.1002/(SICI)1097-0290(20000705)69:1<11::AID-BIT2>3.0.CO;2-J Occurrence Handle1:CAS:528:DC%2BD3cXkt1Wrt78%3D Occurrence Handle10820326

    Article  CAS  PubMed  Google Scholar 

  • V Biou R Dumas C Cohen-Addad R Douce D Job E Pebay-Peyroula (1997) ArticleTitleThe crystal structure of plant acetohydroxy acid isomeroreductase complexed with NADPH, two magnesium ions and a herbicidal transition state analog determined at 1.65 Å resolution. EMBO J 16 3405–3415 Occurrence Handle10.1093/emboj/16.12.3405 Occurrence Handle1:CAS:528:DyaK2sXktlCjt70%3D Occurrence Handle9218783

    Article  CAS  PubMed  Google Scholar 

  • D Borek M Jaskólski (2001) ArticleTitleSequence analysis of enzymes with asparaginase activity. Acta Biochem Polon 48 893–902 Occurrence Handle1:CAS:528:DC%2BD38XhsFKrsb0%3D

    CAS  Google Scholar 

  • D Borek K Michalska K Brzezinski A Kisiel J Podkowinski DT Bonthron D Krowarsch J Otlewski M Jaskolski (2004) ArticleTitleExpression, purification and catalytic activity of Lupinus luteus asparagine β-amidohydrolase and its Escherichia coli homolog. Eur J Biochem 271 3215–3226 Occurrence Handle10.1111/j.1432-1033.2004.04254.x Occurrence Handle1:CAS:528:DC%2BD2cXmsFCit78%3D Occurrence Handle15265041

    Article  CAS  PubMed  Google Scholar 

  • U Breitinger T Clausen S Ehlert R Huber B Laber F Schmidt E Pohl A Messerschmidt (2001) ArticleTitleThe three-dimensional structure of cystathionine β-lyase from Arabidopsis and its substrate specificity. Plant Physiol 126 631–642 Occurrence Handle10.1104/pp.126.2.631 Occurrence Handle1:CAS:528:DC%2BD3MXks1Gmsro%3D Occurrence Handle11402193

    Article  CAS  PubMed  Google Scholar 

  • MR Brochetto-Braga A Leite P Arruda (1992) ArticleTitlePartial purification and characterization of lysine-oxoglutarate reductase activity in normal and opaque-2 maize endosperms. Plant Physiol 98 1139–1147 Occurrence Handle1:CAS:528:DyaK38XitFSjsLY%3D

    CAS  Google Scholar 

  • LS Camargos LF Aguiar RA Azevedo (2004) ArticleTitleVariation in the amino acid concentration during development of Canavalia ensiformes. Biol Plant 48 309–312 Occurrence Handle10.1023/B:BIOP.0000033463.98440.db Occurrence Handle1:CAS:528:DC%2BD2cXptVeltbY%3D

    Article  CAS  Google Scholar 

  • MA Campbell JK Patel JL Meyers LC Myrick JL Gustin (2001) ArticleTitleGenes encoding for branched-chain amino acid aminotransferase are differentially expressed in plants. Plant Physiol Biochem 39 855–860 Occurrence Handle10.1016/S0981-9428(01)01306-7 Occurrence Handle1:CAS:528:DC%2BD3MXntlyjuro%3D

    Article  CAS  Google Scholar 

  • A Casado JL Caballero AR Franco J Cárdenas MR Grant J Munoz-Blanco (1995) ArticleTitleMolecular cloning of the gene encoding the L-asparaginase gene of Arabidopsis thaliana. Plant Physiol 108 1321–1322 Occurrence Handle10.1104/pp.108.3.1321 Occurrence Handle1:CAS:528:DyaK2MXmvFGls70%3D Occurrence Handle7630960

    Article  CAS  PubMed  Google Scholar 

  • AP Casazza A Basner R Hofgen H Hesse (2000) ArticleTitleExpression of threonine synthase from Solanum tuberosum L. is not metabolically regulated by photosynthesis related signals or by nitrogenous compounds. Plant Sci 157 43–50 Occurrence Handle10.1016/S0168-9452(00)00265-X Occurrence Handle1:CAS:528:DC%2BD3cXlsFCjt70%3D Occurrence Handle10940468

    Article  CAS  PubMed  Google Scholar 

  • C Chaffei K Pageau A Suzuki H Gouia MH Ghorbel C Masclaux-Daubresse (2004) ArticleTitleCadmium toxicity induced changes in nitrogen management in Lycopersicon esculentum leading to a metabolic safeguard through an amino acid storage strategy. Plant Cell Physiol 45 1681–1693 Occurrence Handle10.1093/pcp/pch192 Occurrence Handle1:CAS:528:DC%2BD2cXhtVGis7nM Occurrence Handle15574844

    Article  CAS  PubMed  Google Scholar 

  • EP Chagas L Sodek (2001) ArticleTitlePurification and properties of asparaginase from the testa of immature seeds of pea (Pisum sativum L.). Braz Arch Biol Technol 44 239–246 Occurrence Handle10.1590/S1516-89132001000300004 Occurrence Handle1:CAS:528:DC%2BD38XlsVWitA%3D%3D

    Article  CAS  Google Scholar 

  • Y Chiba M Ishikawa F Kijima RH Tyson J Kim A Yamamoto E Nambara T Leustek RM Wallsgrove S Naito (1999) ArticleTitleEvidence for autoregulation of cystathionine γ-synthase mRNA stability in Arabidopsis. Science 286 1371–1374 Occurrence Handle10.1126/science.286.5443.1371 Occurrence Handle1:CAS:528:DyaK1MXnsVersro%3D Occurrence Handle10558994

    Article  CAS  PubMed  Google Scholar 

  • Y Chiba R Sakurai M Yoshino K Ominato M Ishikawa H Onouchi S Naito (2003) ArticleTitleS-adenosyl-L-methionine is an effector in the posttranscriptional autoregulation of the cystathionine gamma-synthase gene in Arabidopsis. Proc Natl Acad Sci USA 100 10225–10230 Occurrence Handle1:CAS:528:DC%2BD3sXntFygtbY%3D Occurrence Handle12934018

    CAS  PubMed  Google Scholar 

  • A Craciun M Jacobs M Vauterin (2000) ArticleTitleArabidopsis loss-of-function mutant in the lysine pathway points out complex regulation mechanism. FEBS Lett 487 234–238 Occurrence Handle10.1016/S0014-5793(00)02303-6 Occurrence Handle1:CAS:528:DC%2BD3MXisVShsg%3D%3D Occurrence Handle11150516

    Article  CAS  PubMed  Google Scholar 

  • G Curien S Ravanel R Dumas (2003) ArticleTitleA kinetic model of the branch-point between the methionine and threonine biosynthesis pathways in Arabidopsis thaliana. Eur J Biochem 270 4615–4627 Occurrence Handle10.1046/j.1432-1033.2003.03851.x Occurrence Handle1:CAS:528:DC%2BD3sXpsFagtbg%3D Occurrence Handle14622248

    Article  CAS  PubMed  Google Scholar 

  • D Demidov C Horstmann M Meixner T Pickardt I Saalbach G Galili K Muntz (2003) ArticleTitleAdditive effects of the feed-back insensitive bacterial aspartate kinase and the Brazil nut 2S albumin on the methionine content of transgenic narbon bean (Vicia narbonensis L.). Mol Breeding 11 187–201 Occurrence Handle10.1023/A:1022814506153 Occurrence Handle1:CAS:528:DC%2BD3sXit1Kisbw%3D

    Article  CAS  Google Scholar 

  • C Devaux P Baldet J Joubes M Dieuaide-Noubhani D Just C Chevalier P Raymond (2003) ArticleTitlePhysiological, biochemical and molecular analysis of sugar-starvation responses in tomato roots. J Exp Bot 385 1143–1151

    Google Scholar 

  • R Di J Kim MN Martin T Leustek JW Jhoo CT Ho NE Tumer (2003) ArticleTitleEnhancement of the primary flavour compound methional in potato by increasing the level of soluble methionine. J Agric Food Chem 51 5695–5702 Occurrence Handle10.1021/jf030148c Occurrence Handle1:CAS:528:DC%2BD3sXmt1eiur4%3D Occurrence Handle12952421

    Article  CAS  PubMed  Google Scholar 

  • R Diebold J Schuster K Daschner S Binder (2002) ArticleTitleThe branched-chain amino acid transaminase gene family in Arabidopsis encodes plastid and mitochondrial proteins. Plant Physiol 129 540–550 Occurrence Handle10.1104/pp.001602 Occurrence Handle1:CAS:528:DC%2BD38XkvV2jsbg%3D Occurrence Handle12068099

    Article  CAS  PubMed  Google Scholar 

  • RC Dobson K Valegard JA Gerrard (2004) ArticleTitleThe crystal structure of three site-directed mutants of Escherichia coli dihydrodipicolinate synthase: further evidence for a catalytic triad. J Mol Biol 338 329–339 Occurrence Handle10.1016/j.jmb.2004.02.060 Occurrence Handle1:CAS:528:DC%2BD2cXivVeltL8%3D Occurrence Handle15066435

    Article  CAS  PubMed  Google Scholar 

  • R Dumas D Job JY Ortholand G Emeric A Greiner R Douce (1992) ArticleTitleIsolation and kinetic properties of acetohydroxy acid isomeroreductase from spinach (Spinacia oleracea) chloroplast overexpressed in Escherichia coli. Biochem J 288 865–874 Occurrence Handle1:CAS:528:DyaK3sXjsFSjtw%3D%3D Occurrence Handle1472001

    CAS  PubMed  Google Scholar 

  • R Dumas G Curien RT Derose R Douce (1993) ArticleTitleBranched-chain amino acid biosynthesis in plants – molecular cloning and characterization of the gene encoding acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase) from Arabidopsis thaliana (thale cress). Biochem J 294 821–828 Occurrence Handle1:CAS:528:DyaK3sXmsVantLc%3D Occurrence Handle8379936

    CAS  PubMed  Google Scholar 

  • R Dumas V Biou F Hagland R Douce RG Duggleby (2001) ArticleTitleEnzymology, structure and dynamics of acetohydroxy acid isomeroreductase. Acc Chem Res 34 399–408 Occurrence Handle10.1021/ar000082w Occurrence Handle1:CAS:528:DC%2BD3MXisVOksrs%3D Occurrence Handle11352718

    Article  CAS  PubMed  Google Scholar 

  • J Durner OC Knorzer P Boger (1993) ArticleTitleKetol-acid reductoisomerase from barley (Hordeum vulgare) – purification, properties, and specific inhibition. Plant Physiol 103 903–910 Occurrence Handle1:CAS:528:DyaK2cXis1WjsQ%3D%3D Occurrence Handle12231988

    CAS  PubMed  Google Scholar 

  • A Ebmeier L Allison H Cerutti T Clemente (2004) ArticleTitleEvaluation of the Escherichia coli threonine deaminase gene as a selectable marker for plant transformation. Planta 218 751–758 Occurrence Handle1:CAS:528:DC%2BD2cXitFaht7w%3D Occurrence Handle14673650

    CAS  PubMed  Google Scholar 

  • AR Fernie P Geigenberger M Stitt (2005) ArticleTitleFlux an important, but neglected, component of functional genomics. Curr Opin Plant Biol 8 174–182 Occurrence Handle10.1016/j.pbi.2005.01.008 Occurrence Handle1:CAS:528:DC%2BD2MXitVCntb0%3D Occurrence Handle15752998

    Article  CAS  PubMed  Google Scholar 

  • RR Ferreira VA Varisi LW Meinhardt PJ Lea RA Azevedo (2005a) ArticleTitleAre high-lysine cereal crops still a challenge? Braz J Med Biol Res 38 985–994 Occurrence Handle1:CAS:528:DC%2BD2MXpslWjtr0%3D

    CAS  Google Scholar 

  • RR Ferreira A Vendemiatti PL Gratão PJ Lea RA Azevedo (2005b) ArticleTitleDetermination of aspartate kinase in maize tissues. Sci Agric 62 184–189 Occurrence Handle1:CAS:528:DC%2BD2MXktlWru7s%3D

    CAS  Google Scholar 

  • JL Ferrer S Ravanel M Robert R Dumas (2004) ArticleTitleCrystal structures of cobalamin-independent methionine synthase complexed with zinc, homocysteine, and methyltetrahydrofolate. J Biol Chem 279 44235–44238 Occurrence Handle10.1074/jbc.C400325200 Occurrence Handle1:CAS:528:DC%2BD2cXosFymsrk%3D Occurrence Handle15326182

    Article  CAS  PubMed  Google Scholar 

  • DH Flint MH Emptage (1988) ArticleTitleDihydroxy acid dehydratase from spinach contains a [2FE-2S] cluster. J Biol Chem 263 3558–3564 Occurrence Handle1:CAS:528:DyaL1cXitVSlsL8%3D Occurrence Handle2831190

    CAS  PubMed  Google Scholar 

  • RF Fornazier SA Gaziola CV Helm PJ Lea RA Azevedo (2005) ArticleTitleIsolation and characterization of enzymes involved in lysine catabolism from sorghum seeds. J Agric Food Chem 53 1791–1798 Occurrence Handle10.1021/jf048525o Occurrence Handle1:CAS:528:DC%2BD2MXht1aquro%3D Occurrence Handle15740075

    Article  CAS  PubMed  Google Scholar 

  • V Frankard M Vauterin M Jacobs (1997) ArticleTitleMolecular characterization of an Arabidopsis thaliana cDNA coding for a monofunctional aspartate kinase. Plant Mol Biol 34 233–242 Occurrence Handle10.1023/A:1005863128558 Occurrence Handle1:CAS:528:DyaK2sXktlWls7w%3D Occurrence Handle9207839

    Article  CAS  PubMed  Google Scholar 

  • B Gakiere L Denis M Droux D Job (2002) ArticleTitleOver-expression of cystathionine γ-synthase in Arabidopsis thaliana leads to increased levels of methionine and S-adenosylmethionine. Plant Physiol Biochem 40 119–126 Occurrence Handle1:CAS:528:DC%2BD38XhtlCjsr4%3D

    CAS  Google Scholar 

  • G Galili (2002) ArticleTitleNew insights into the regulation and functional significance of lysine metabolism in plants. Annu Rev Plant Biol 53 27–43 Occurrence Handle10.1146/annurev.arplant.53.091401.110929 Occurrence Handle1:CAS:528:DC%2BD38XlsVWhtb4%3D Occurrence Handle12221976

    Article  CAS  PubMed  Google Scholar 

  • S Galili D Guenoune S Wininger B Hana A Schupper B Ben-Dor Y Kapulnik (2000) ArticleTitleEnhanced levels of free and protein-bound threonine in transgenic alfalfa (Medicago sativa L.) expressing a bacterial feedback-insensitive aspartate kinase gene. Transgenic Res 9 137–144 Occurrence Handle10.1023/A:1008991625001 Occurrence Handle1:CAS:528:DC%2BD3cXlvVCjsr8%3D Occurrence Handle10951697

    Article  CAS  PubMed  Google Scholar 

  • K Gallardo C Job SPC Groot M Puype H Demol J Vanderkerckhove D Job (2002) ArticleTitleImportance of methionine biosynthesis for Arabidopsis seed germination and seedling growth. Physiol Plant 116 238–247 Occurrence Handle10.1034/j.1399-3054.2002.1160214.x Occurrence Handle1:CAS:528:DC%2BD38XnslSktbY%3D Occurrence Handle12354201

    Article  CAS  PubMed  Google Scholar 

  • EL Garcia GS Mourad (2004) ArticleTitleA site-directed mutagenesis interrogation of the carboxy-terminal end of Arabidopsis thaliana threonine dehydratase/deaminase reveals a synergistic interaction between two effectors-binding sites and contributes to the development of a novel selectable marker. Plant Mol Biol 55 121–134 Occurrence Handle10.1007/s11103-004-0500-z Occurrence Handle1:CAS:528:DC%2BD2cXhtFSisLfM Occurrence Handle15604669

    Article  CAS  PubMed  Google Scholar 

  • M Garrido-Franco S Ehlert A Messerschmidt S Marinkovic R Huber B Laber GP Biurenkov T Clausen (2002) ArticleTitleStructure and function of threonine synthase from yeast. J Biol Chem 277 12396–12405 Occurrence Handle10.1074/jbc.M108734200 Occurrence Handle1:CAS:528:DC%2BD38XivVeku7Y%3D Occurrence Handle11756443

    Article  CAS  PubMed  Google Scholar 

  • C Gary P Baldet N Bertin C Devaux M Tchamitchian P Raymond (2003) ArticleTitleTime-course of tomato whole-pant respiration and fruit and stem growth during prolonged darkness in relation to carbohydrate reserves. Ann Bot 91 429–438 Occurrence Handle10.1093/aob/mcg037 Occurrence Handle1:CAS:528:DC%2BD3sXivVGqtr4%3D Occurrence Handle12588722

    Article  CAS  PubMed  Google Scholar 

  • SA Gaziola CMG Teixeira J Lugli L Sodek RA Azevedo (1997) ArticleTitleThe enzymology of lysine catabolism in rice seeds. Isolation, characterization, and regulatory properties of a lysine 2-oxoglutarate reductase/saccharopine dehydrogenase bifunctional polypetide. Eur J Biochem 247 364–371 Occurrence Handle10.1111/j.1432-1033.1997.00364.x Occurrence Handle1:CAS:528:DyaK2sXksFGhs7k%3D Occurrence Handle9249048

    Article  CAS  PubMed  Google Scholar 

  • SA Gaziola ES Alessi PEO Guimarães C Damerval RA Azevedo (1999) ArticleTitleQuality protein maize: a biochemical study of enzymes involved in lysine metabolism. J Agric Food Chem 47 1268–1275 Occurrence Handle10.1021/jf980940r Occurrence Handle1:CAS:528:DyaK1MXhtFCksb4%3D Occurrence Handle10552448

    Article  CAS  PubMed  Google Scholar 

  • SA Gaziola L Sodek P Arruda PJ Lea RA Azevedo (2000) ArticleTitleDegradation of lysine in rice seeds: effect of calcium, ionic strength, S-adenosylmethionine and S-2-aminoethyl-L-cysteine on the lysine 2-oxoglutarate reductase-saccharopine dehydrogenase bifunctional enzyme. Physiol Plant 110 164–171 Occurrence Handle10.1034/j.1399-3054.2000.110204.x Occurrence Handle1:CAS:528:DC%2BD3cXnt1CntLg%3D

    Article  CAS  Google Scholar 

  • J Giovanelli SH Mudd AH Datko (1989) ArticleTitleRegulatory structure of the biosynthetic pathway for the aspartate family of amino acids in Lemna paucicostata Hegelm 6746, with special reference to the role of aspartokinase. Plant Physiol 90 1584–1599 Occurrence Handle1:CAS:528:DyaL1MXltlSrt7k%3D

    CAS  Google Scholar 

  • K Gokulan B Rupp MS Pavelka WR Jacobs JC Sacchettini (2003) ArticleTitleCrystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesis. J Biol Chem 278 18588–18596 Occurrence Handle10.1074/jbc.M301549200 Occurrence Handle1:CAS:528:DC%2BD3sXjs1KhtL4%3D Occurrence Handle12637582

    Article  CAS  PubMed  Google Scholar 

  • M Gonçalves-Butruille P Szajner E Torigoi A Leite P Arruda (1996) ArticleTitlePurification and characterization of the bifunctional enzyme lysine-ketoglutarate reductase-saccharopine dehydrogenase from maize. Plant Physiol 110 765–771 Occurrence Handle12226216

    PubMed  Google Scholar 

  • DB Goto M Ogi F Kijima T Kumagai F Van Werven H Onouchi S Naito (2002) ArticleTitleA single-nucleotide mutation in a gene encoding S-adenosylmethionine synthetase is associated with methionine over-accumulation phenotype in Arabidopsis thaliana. Genes Genet Syst 77 89–95 Occurrence Handle10.1266/ggs.77.89 Occurrence Handle1:CAS:528:DC%2BD38XmtlGgtL0%3D Occurrence Handle12087191

    Article  CAS  PubMed  Google Scholar 

  • PL Gratão A Polle PJ Lea RA Azevedo (2005a) ArticleTitleMaking the life of heavy metal-stressed plants a little easier. Funct Plant Biol 32 481–494 Occurrence Handle10.1071/FP05016

    Article  Google Scholar 

  • PL Gratão MNV Prasad PF Cardoso PJ Lea RA Azevedo (2005b) ArticleTitlePhytoremediation: green technology for the clean up of toxic metals in the environment. Braz J Plant Physiol 17 53–64

    Google Scholar 

  • A Hadfield C Shammas G Kryger D Ringe GA Petsko J Ouyang RE Viola (2001) ArticleTitleActive site analysis of the antimicrobial target aspartate semialdehyde dehydrogenase. Biochemistry 40 14475–14483 Occurrence Handle10.1021/bi015713o Occurrence Handle1:CAS:528:DC%2BD3MXotV2ksL4%3D Occurrence Handle11724560

    Article  CAS  PubMed  Google Scholar 

  • P Hagelstein B Sieve M Klein H Jans G Schultz (1997) ArticleTitleLeucine synthesis in chloroplasts: leucine/isoleucine aminotransferase and valine aminotransferases are different enzymes in spinach chloroplasts. J Plant Physiol 150 23–30 Occurrence Handle1:CAS:528:DyaK2sXhtVCru7s%3D

    CAS  Google Scholar 

  • F Halgand R Dumas V Biou JP Andrieu K Thomazeau J Gagnon R Douce E Forest (1999) ArticleTitleCharacterization of the conformational changes of acetohydroxy acid isomeroreductase induced by binding of Mg2+ ions, NADPH, and a competitive inhibitor. Biochemistry 38 6025–6034 Occurrence Handle10.1021/bi982412e Occurrence Handle1:CAS:528:DyaK1MXisVaqtrg%3D Occurrence Handle10320328

    Article  CAS  PubMed  Google Scholar 

  • F Halgand PM Wessel O Laprevote R Dumas (2002) ArticleTitleBiochemical and mass spectrometric evidence for quaternary structure modifications of plant threonine deaminase induced by isoleucine. Biochemistry 41 13767–13773 Occurrence Handle10.1021/bi0262348 Occurrence Handle1:CAS:528:DC%2BD38XnvV2nsLw%3D Occurrence Handle12427039

    Article  CAS  PubMed  Google Scholar 

  • AU Hejazi MK Piotukh J Mattow R Deutzmann R Volkmer-Engert W Lockau (2002) ArticleTitleIsoaspartyl dipeptidase activity of plant-type asparaginases. Biochem J 364 129–136 Occurrence Handle1:CAS:528:DC%2BD38XktFWiu7c%3D Occurrence Handle11988085

    CAS  PubMed  Google Scholar 

  • CV Helm A De Francisco SA Gaziola RF Fornazier GB Pompeu RA Azevedo (2004) ArticleTitleHull-less barley varieties: storage proteins and amino acid distribution in relation to nutritional quality. Food Biotechnol 18 327–341 Occurrence Handle10.1081/FBT-200040531 Occurrence Handle1:CAS:528:DC%2BD2cXptlSrsbo%3D

    Article  CAS  Google Scholar 

  • B Heremans M Jacobs (1997) ArticleTitleA mutant of Arabidopsis thaliana (L.) Heynh. with modified control of aspartate kinase by threonine. Biochem Genet 35 139–153 Occurrence Handle10.1023/A:1022265825402 Occurrence Handle1:CAS:528:DyaK2sXksFagsrg%3D Occurrence Handle9241437

    Article  CAS  PubMed  Google Scholar 

  • D Hermsmeier U Schittko IT Baldwin (2001) ArticleTitleMolecular interactions between the specialist herbivore Manduca sexta (Lepidoptera, Sphingidae) and its natural host Nicotiana attenuata. I. Large-scale changes in the accumulation of growth- and defense-related plant mRNAs. Plant Physiol 125 683–700 Occurrence Handle10.1104/pp.125.2.683 Occurrence Handle1:CAS:528:DC%2BD3MXhs1KlsLw%3D Occurrence Handle11161026

    Article  CAS  PubMed  Google Scholar 

  • MB Herrera-Rodriguez JM Maldonado R Perez-Vicente (2004) ArticleTitleLight and metabolic regulation of HAS1, HAS1.1 and HAS2, three asparagine synthetase genes in Helianthus annuus. Plant Physiol Biochem 42 511–518 Occurrence Handle1:CAS:528:DC%2BD2cXlsFyku7s%3D Occurrence Handle15246064

    CAS  PubMed  Google Scholar 

  • H Hesse R Hoefgen (2003) ArticleTitleMolecular aspects of methionine biosynthesis. Trends Plant Sci 8 259–262 Occurrence Handle10.1016/S1360-1385(03)00107-9 Occurrence Handle1:CAS:528:DC%2BD3sXksF2hur8%3D Occurrence Handle12818659

    Article  CAS  PubMed  Google Scholar 

  • H Hesse V Nikiforova B Gakiere R Hoefgen (2004a) ArticleTitleMolecular analysis and control of cysteine biosynthesis: integration of nitrogen and sulphur metabolism. J Exp Bot 55 1283–1292 Occurrence Handle1:CAS:528:DC%2BD2cXkvVSrsbo%3D

    CAS  Google Scholar 

  • H Hesse O Kreft S Maimann M Zeh R Hoefgen (2004b) ArticleTitleCurrent understanding of the regulation of methionine biosynthesis in plants. J Exp Bot 55 1799–1808 Occurrence Handle1:CAS:528:DC%2BD2cXntFaisbk%3D

    CAS  Google Scholar 

  • AO Hudson C Bless P Macedo SP Chatterjee BK Singh C Gilvarg T Leustek (2005) ArticleTitleBiosynthesis of lysine in plants: evidence for a variant of the known bacterial pathways. Biochim Biophys Acta 1721 27–36 Occurrence Handle1:CAS:528:DC%2BD2MXivVSqsw%3D%3D Occurrence Handle15652176

    CAS  PubMed  Google Scholar 

  • BG Hunter MK Beatty GW Singletary BR Hamaker BP Dilkes BA Larkins R Jung (2002) ArticleTitleMaize opaque endosperm mutations create extensive changes in patterns of gene expression. Plant Cell 14 2591–2612 Occurrence Handle10.1105/tpc.003905 Occurrence Handle1:CAS:528:DC%2BD38XotFelsb4%3D Occurrence Handle12368507

    Article  CAS  PubMed  Google Scholar 

  • K Inaba T Fujiwara H Hayashi M Chino Y Komeda S Naito (1994) ArticleTitleIsolation of an Arabidopsis thaliana mutant, mto1, that overaccumulates soluble methionine: temporal and spatial patterns of soluble methionine accumulation. Plant Physiol 104 881–887 Occurrence Handle1:CAS:528:DyaK2cXis1Kjsro%3D Occurrence Handle12232133

    CAS  PubMed  Google Scholar 

  • WT Jones T Al-Samarrai JM Reeves GB Ryan CA Kirk E Vincze D Harvey M McCambridge D Greenwood PHS Reynolds (2004) ArticleTitleThe trans-acting protein interacting with the DNA motif proximal to the transcriptional start site of plant L-asparaginase is bacterial sarcosine oxidase. J Bacteriol 186 811–817 Occurrence Handle10.1128/JB.186.3.811-817.2004 Occurrence Handle1:CAS:528:DC%2BD2cXot1aguw%3D%3D Occurrence Handle14729708

    Article  CAS  PubMed  Google Scholar 

  • KW Joy (1988) ArticleTitleAmmonia, glutamine and asparagines – a carbon nitrogen interface. Can J Bot 66 2103–2109 Occurrence Handle1:CAS:528:DyaL1MXjs1Ojtw%3D%3D

    CAS  Google Scholar 

  • SM Jung DT Le SS Yoon MY Yoon YT Kim JD Choi (2004) ArticleTitleAmino acid residues conferring herbicide resistance in tobacco acetohydroxy acid synthase. Biochem J 383 53–61 Occurrence Handle1:CAS:528:DC%2BD2cXnslOqs7Y%3D Occurrence Handle15214847

    CAS  PubMed  Google Scholar 

  • T Kawachi K Sueyoshi A Nakajima H Yamagata T Sugimoto Y Oji (2002) ArticleTitleExpression of asparagine synthetase in rice (Oryza sativa) roots in response to nitrogen. Physiol Plant 114 41–46 Occurrence Handle10.1034/j.1399-3054.2002.1140107.x Occurrence Handle1:CAS:528:DC%2BD38XjvFehurs%3D Occurrence Handle11982933

    Article  CAS  PubMed  Google Scholar 

  • JG Kelland MM Palcic MA Pickard JC Vederas (1985) ArticleTitleStereochemistry of lysine formation by meso-diaminopimelate decarboxylase from wheat germ: use of 1H-13C NMR shift correlation to detect stereospecific deuterium labeling. Biochemistry 25 3263–3267

    Google Scholar 

  • EL Kemper G Cord-Neto AN Capella M Gonçalves-Butruille RA Azevedo P Arruda (1998) ArticleTitleStructure and regulation of the bifunctional enzyme lysine-oxoglutarate reductase-saccharopine dehydrogenase in maize. Eur J Biochem 253 720–729 Occurrence Handle10.1046/j.1432-1327.1998.2530720.x Occurrence Handle1:CAS:528:DyaK1cXkt1Sqtbw%3D Occurrence Handle9654071

    Article  CAS  PubMed  Google Scholar 

  • EL Kemper G Cord-Neto F Papes KC Martinez Moraes A Leite P Arruda (1999) ArticleTitleThe role of opaque-2 on the control of lysine degrading activities in developing maize endosperm. Plant Cell 11 1981–1994 Occurrence Handle10.1105/tpc.11.10.1981 Occurrence Handle1:CAS:528:DyaK1MXntFCgtLs%3D Occurrence Handle10521527

    Article  CAS  PubMed  Google Scholar 

  • J Kim T Leustek (2000) ArticleTitleRepression of cystathionine γ-synthase in Arabidopsis thaliana produces partial methionine auxotrophy and developmental abormalities. Plant Sci 151 9–18 Occurrence Handle10.1016/S0168-9452(99)00188-0 Occurrence Handle1:CAS:528:DyaK1MXotVKqtLY%3D

    Article  CAS  Google Scholar 

  • J Kim M Lee R Chalam MN Martin T Leustek W Boerjan (2002) ArticleTitleConstitutive overexpression of cystathionine γ-synthase in Arabidopsis leads to accumulation of soluble methionine and S-methylmethionine. Plant Physiol 128 95–107 Occurrence Handle10.1104/pp.128.1.95 Occurrence Handle1:CAS:528:DC%2BD38XmvVSkug%3D%3D Occurrence Handle11788756

    Article  CAS  PubMed  Google Scholar 

  • J Kim DG Beak YT Kim JD Choi MY Yoon (2004) ArticleTitleEffects of deletions at the C-terminus of tobacco acetohydroxyacid synthase on the enzyme activity and cofactor binding. Biochem J 384 59–68 Occurrence Handle1:CAS:528:DC%2BD2cXpsVKksL8%3D Occurrence Handle15521822

    CAS  PubMed  Google Scholar 

  • A Kochevenko L Willmitzer (2003) ArticleTitleChimeric RNA/DNA oligonucleotide-based site-specific modification of the tobacco acetolactate syntase gene. Plant Physiol 132 174–184 Occurrence Handle10.1104/pp.102.016857 Occurrence Handle1:CAS:528:DC%2BD3sXktVGgsL4%3D Occurrence Handle12746523

    Article  CAS  PubMed  Google Scholar 

  • O Kreft R Hoefgen H Hesse (2003) ArticleTitleFunctional analysis of cystathionine γ-synthase in genetically engineered potato plants. Plant Physiol 131 1843–1854 Occurrence Handle10.1104/pp.102.015933 Occurrence Handle1:CAS:528:DC%2BD3sXjt1SqsbY%3D Occurrence Handle12692344

    Article  CAS  PubMed  Google Scholar 

  • SS Krishna T Zhou M Daugherty A Osterman H Zhang (2001) ArticleTitleStructural basis for the catalysis and substrate specificity of homoserine kinase. Biochemistry 40 10810–10818 Occurrence Handle10.1021/bi010851z Occurrence Handle1:CAS:528:DC%2BD3MXlvFCku7g%3D Occurrence Handle11535056

    Article  CAS  PubMed  Google Scholar 

  • B Laber W Maurer C Hanke S Grafe S Ehlert A Messerschmidt T Clausen (1999) ArticleTitleCharacterization of recombinant Arabidopsis thaliana threonine synthase. Eur J Biochem 263 212–221 Occurrence Handle10.1046/j.1432-1327.1999.00487.x Occurrence Handle1:CAS:528:DyaK1MXkslKrtro%3D Occurrence Handle10429206

    Article  CAS  PubMed  Google Scholar 

  • HM Lam K Coschigano C Schultz R Melo-Oliveira G Tjaden I Oliveira N Ngai MH Hsieh G Coruzzi (1995) ArticleTitleUse of Arabidopsis mutants and genes to study amide amino acid biosynthesis. Plant Cell 7 887–898 Occurrence Handle10.1105/tpc.7.7.887 Occurrence Handle1:CAS:528:DyaK2MXnt1Sgtrw%3D Occurrence Handle7640525

    Article  CAS  PubMed  Google Scholar 

  • HM Lam KT Coschigano IC Oliveira R Melo-Oliveira GM Coruzzi (1996) ArticleTitleThe molecular-genetics of nitrogen assimilation into amino acids in higher plants. Annu Rev Plant Physiol Plant Biol 47 569–593 Occurrence Handle1:CAS:528:DyaK28XjtlWgt74%3D

    CAS  Google Scholar 

  • HM Lam P Wong HK Chan KM Yam L Chen CM Chow GM Coruzzi (2003) ArticleTitleOverexpression of the ASN1 gene enhances nitrogen status in seeds of Arabidopsis. Plant Physiol 132 926–935 Occurrence Handle10.1104/pp.103.020123 Occurrence Handle1:CAS:528:DC%2BD3sXkslertLk%3D Occurrence Handle12805621

    Article  CAS  PubMed  Google Scholar 

  • I Lambein Y Chiba H Onouchi S Naito (2003) ArticleTitleDecay kinetics of autogenously regulated CGS1 mRNA that codes for cystathionine γ-synthase in Arabidopsis thaliana. Plant Cell Physiol 44 893–900 Occurrence Handle10.1093/pcp/pcg114 Occurrence Handle1:CAS:528:DC%2BD3sXnslKkt74%3D Occurrence Handle14519770

    Article  CAS  PubMed  Google Scholar 

  • F Lamblin G Saladin B Dehorter D Cronier E Grenier J Lacoux P Bruyant E Laine B Chabbert F Girault B Monties C Morvan H David A David (2001) ArticleTitleOverexpression of a heterologous sam gene encoding S-adenosylmethionine synthetase in flax (Linum usitatissimum) cells: Consequences on methylation of lignin precursors and pectins. Physiol Plant 112 223–232 Occurrence Handle10.1034/j.1399-3054.2001.1120211.x Occurrence Handle1:CAS:528:DC%2BD3MXktFeltrc%3D Occurrence Handle11454228

    Article  CAS  PubMed  Google Scholar 

  • Lea PJ, Azevedo RA (2003) Primary products: plant amino acids. In: Thomas B, Murphy SJ, Murray BG (eds) Encyclopaedia of applied plant sciences, vol 3. Elsevier, Amsterdam, pp 871–883

  • Lea PJ, Robinson SA, Stewart GR (1990) The enzymology and metabolism of glutamine, glutamate and asparagine. In: Miflin BJ, Lea PJ (eds) The biochemistry of plants, vol 16. Academic Press, San Diego, CA, pp 147–152

  • PJ Lea ZH Chen RC Leegood RP Walker (2001) ArticleTitleDoes phosphoenolpyruvate carboxykinase have a role in both amino acid and carbohydrate metabolism? Amino Acids 20 225–241 Occurrence Handle10.1007/s007260170041 Occurrence Handle1:CAS:528:DC%2BD3MXks1Gjsro%3D Occurrence Handle11354601

    Article  CAS  PubMed  Google Scholar 

  • M Lee T Leustek (1999) ArticleTitleIdentification of the gene encoding homoserine kinase from Arabidopsis thaliana and characterization of the recombinant enzyme derived from the gene. Arch Biochem Biophys 372 135–142 Occurrence Handle1:CAS:528:DyaK1MXnt1Ors78%3D Occurrence Handle10562426

    CAS  PubMed  Google Scholar 

  • M Lee MN Martin AO Hudson J Lee MJ Muhitch T Leustek (2005a) ArticleTitleMethionine and threonine synthesis are limited by homoserine availability and not the activity of homoserine kinase in Arabidopsis thaliana. Plant J 41 685–696 Occurrence Handle10.1111/j.1365-313X.2004.02329.x Occurrence Handle1:CAS:528:DC%2BD2MXisVWitb4%3D

    Article  CAS  Google Scholar 

  • SI Lee HU Kim YH Lee SC Suh YP Lim HY Lee HI Kim (2001) ArticleTitleConstitutive and seed-specific expression of a maize lysine-feedback-insensitive dihydrodipicolinate synthase gene leads to increased free lysine in rice seeds. Mol Breed 8 75–84 Occurrence Handle10.1023/A:1011977219926 Occurrence Handle1:CAS:528:DC%2BD3MXotl2ksL4%3D

    Article  CAS  Google Scholar 

  • YT Lee RG Duggleby (2001) ArticleTitleIndentification of the regulatory subunit of Arabidopsis thaliana acetohydroxyacid synthase and reconstitution with its catalytic subunit. Biochemistry 40 6836–6844 Occurrence Handle1:CAS:528:DC%2BD3MXjsVOltb8%3D Occurrence Handle11389597

    CAS  PubMed  Google Scholar 

  • YT Lee RG Duggleby (2002) ArticleTitleRegulatory interactions in Arabidopsis thaliana acetohydroxyacid synthase. FEBS Lett 512 180–184 Occurrence Handle1:CAS:528:DC%2BD38XhtlGhur4%3D Occurrence Handle11852076

    CAS  PubMed  Google Scholar 

  • YT Lee HT Ta RG Duggleby (2005b) ArticleTitleCyclopropane-1,1-dicarboxylate is a slow tight-binding inhibitor of rice ketol-acid reductoisomerase. Plant Science 168 1035–1040 Occurrence Handle10.1016/j.plantsci.2004.11.020 Occurrence Handle1:CAS:528:DC%2BD2MXhslWns7Y%3D

    Article  CAS  Google Scholar 

  • CC Lim JZ Liu EC Pua (2002) ArticleTitleCharacterization of S-adenosylmethionine synthetase genes and its expression is associated with ethylene synthesis in mustard (Brassica juncea). Physiol Plant 116 522–530 Occurrence Handle10.1034/j.1399-3054.2002.1160411.x Occurrence Handle1:CAS:528:DC%2BD38XptlejsbY%3D

    Article  CAS  Google Scholar 

  • JD Lima L Sodek (2003) ArticleTitleN-stress alters aspartate and asparagine levels of xylem sap in soybean. Plant Sci 165 649–656 Occurrence Handle10.1016/S0168-9452(03)00251-6 Occurrence Handle1:CAS:528:DC%2BD3sXlvVSku7Y%3D

    Article  CAS  Google Scholar 

  • STC Lima RA Azevedo LG Santoro (2003a) ArticleTitleImproved procedures for extraction of lysine 2-oxoglutarate reductase/saccharopine dehydrogenase (LOR/SDH) enzyme from Phaseolus vulgaris cultivars. New Zeal J Crop Hort Sci 31 261–268 Occurrence Handle1:CAS:528:DC%2BD3sXpsFWqt70%3D

    CAS  Google Scholar 

  • STC Lima RA Azevedo LG Santoro SA Gaziola PJ Lea (2003b) ArticleTitleIsolation of the bifunctional enzyme lysine 2-oxoglutarate reductase-saccharopine dehydrogenase from Phaseolus vulgaris. Amino Acids 24 179–186

    Google Scholar 

  • JF Lin SH Wu (2004) ArticleTitleMolecular events in senescing Arabidopsis leaves. Plant J 39 612–628 Occurrence Handle10.1111/j.1365-313X.2004.02160.x Occurrence Handle1:CAS:528:DC%2BD2cXnslOms74%3D Occurrence Handle15272878

    Article  CAS  PubMed  Google Scholar 

  • MA Lopes K Takasaki DE Bostwick T Helentjaris BA Larkins (1995) ArticleTitleIdentification of two opaque2 modifier loci in Quality Protein Maize. Mol Gen Genet 247 603–613 Occurrence Handle10.1007/BF00290352 Occurrence Handle1:CAS:528:DyaK2MXmvFagtr0%3D Occurrence Handle7603440

    Article  CAS  PubMed  Google Scholar 

  • TJ Lough BD Reddington MR Grant DF Hill PHS Reynolds KJF Farnden (1992) ArticleTitleThe isolation and characterization of a cDNA clone encoding L-asparaginase from developing seeds of lupin (Lupinus arboreus). Plant Mol Biol 19 391–399 Occurrence Handle10.1007/BF00023386 Occurrence Handle1:CAS:528:DyaK38Xls1Kmuro%3D Occurrence Handle1377963

    Article  CAS  PubMed  Google Scholar 

  • J Lugli A Campbell SA Gaziola PJ Lea RA Azevedo (2002) ArticleTitleEnzymes of lysine metabolism from Coix lacryma-jobi seeds. Plant Physiol Biochem 40 25–32 Occurrence Handle10.1016/S0981-9428(01)01343-2 Occurrence Handle1:CAS:528:DC%2BD38XhtF2is7o%3D

    Article  CAS  Google Scholar 

  • XL Ma ZL Wang YC Qi YX Zhao H Zhang (2003) ArticleTitleIsolation of S-adenosylmethionine synthetase gene from Suaeda salsa and its differential expression under NaCl stress. Acta Bot Sin 45 1359–1365 Occurrence Handle1:CAS:528:DC%2BD2MXis1Olt7w%3D

    CAS  Google Scholar 

  • S Maimann C Wagner O Kreft M Zeh L Willmitzer R Hoefgen H Hesse (2000) ArticleTitleTransgenic potato plants reveal the indispensable role of cystathionine β-lyase in plant growth and development. Plant J 23 747–758 Occurrence Handle10.1046/j.1365-313x.2000.00842.x Occurrence Handle1:CAS:528:DC%2BD3cXnslWgt78%3D Occurrence Handle10998186

    Article  CAS  PubMed  Google Scholar 

  • S Maimann R Hoefgen H Hesse (2001) ArticleTitleEnhanced cystathionine β-lyase activity in transgenic potato plants does not force metabolite flow towards methionine. Planta 214 163–170 Occurrence Handle1:CAS:528:DC%2BD3MXovFKnsrY%3D Occurrence Handle11800379

    CAS  PubMed  Google Scholar 

  • BJ Mazur C-F Chui JK Smith (1987) ArticleTitleIsolation and characterization of plant genes coding for acetolactate synthase, the target enzyme for two classes of herbicides. Plant Physiol 85 1110–1117 Occurrence Handle1:CAS:528:DyaL1cXhvF2iu7w%3D

    CAS  Google Scholar 

  • JA McCourt SS Pang LW Guddat RG Duggleby (2005) ArticleTitleElucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase. Biochemistry 44 2330–2338 Occurrence Handle10.1021/bi047980a Occurrence Handle1:CAS:528:DC%2BD2MXnsVCntQ%3D%3D Occurrence Handle15709745

    Article  CAS  PubMed  Google Scholar 

  • LO Medici RA Azevedo RJ Smith PJ Lea (2004a) ArticleTitleThe influence of nitrogen supply on antioxidant enzymes in plant roots. Funct Plant Biol 31 1–9 Occurrence Handle10.1071/FP03130 Occurrence Handle1:CAS:528:DC%2BD2cXmvVGgtQ%3D%3D

    Article  CAS  Google Scholar 

  • LO Medici MB Pereira PJ Lea RA Azevedo (2004b) ArticleTitleDiallel analysis of maize lines with contrasting responses to applied nitrogen. J Agric Sci Cambridge 142 535–541 Occurrence Handle1:CAS:528:DC%2BD2MXisFKht74%3D

    CAS  Google Scholar 

  • B Miesak GM Coruzzi (2002) ArticleTitleMolecular and physiological analysis of Arabidopsis mutants defective in cytosolic or chloroplastic aspartate aminotransferase. Plant Physiol 129 650–660 Occurrence Handle10.1104/pp.005090 Occurrence Handle1:CAS:528:DC%2BD38XkvV2jtrg%3D Occurrence Handle12068109

    Article  CAS  PubMed  Google Scholar 

  • BJ Miflin (1974) ArticleTitleThe location of nitrite reductase and other enzymes related to amino acid biosynthesis in the plastids of root and leaves. Plant Physiol 54 550–555 Occurrence Handle1:CAS:528:DyaE2MXhsVShtA%3D%3D

    CAS  Google Scholar 

  • A Migge C Bork R Hell TW Becker (2000) ArticleTitleNegative regulation of nitrate reductase gene expression by glutamine or asparagine accumulating in leaves or sulfur-deprived tobacco. Planta 211 587–595 Occurrence Handle10.1007/s004250000322 Occurrence Handle1:CAS:528:DC%2BD3cXmt12itro%3D Occurrence Handle11030559

    Article  CAS  PubMed  Google Scholar 

  • D Miron S Ben-Yaacov H Karchi G Galili (1997) ArticleTitleIn vitro dephosphorylation inhibits the activity of soybean lysine-ketoglutarate reductase in a lysine-regulated manner. Plant J 12 1453–1458 Occurrence Handle10.1046/j.1365-313x.1997.12061453.x Occurrence Handle1:CAS:528:DyaK1cXlvVWhsQ%3D%3D

    Article  CAS  Google Scholar 

  • MG Moeller C Taylor SK Rasmussen PB Holm (2003) ArticleTitleMolecular cloning and characterization of two genes encoding asparagine synthetase in barley (Hordeum vulgare L.). Biochim Biophys Acta 1628 123–132

    Google Scholar 

  • MJ Muhitch (1997) ArticleTitleEffects of overexpressing E. coli threonine synthase in tobacco (Nicotiana tabacum) suspension culture cells on free amino acid levels, aspartate pathway enzyme activities and uptake of aspartate into cells. J Plant Physiol 150 16–22 Occurrence Handle1:CAS:528:DyaK2sXhtVCru7o%3D

    CAS  Google Scholar 

  • S Nabha F Lamblin F Gillet D Laurain M Fliniaux A David A Jacquin (1999) ArticleTitlePolyamine content and somatic embryogenesis in Papaver somniferum cells transformed with sam-1 gene. J Plant Physiol 154 729–734 Occurrence Handle1:CAS:528:DyaK1MXktF2nu7Y%3D

    CAS  Google Scholar 

  • Y Narita H Taguchi T Nakamura A Ueda WM Shi T Takabe (2004) ArticleTitleCharacterisation of the salt-inducible methionine synthase from barley leaves. Plant Sci 167 1009–1016 Occurrence Handle10.1016/j.plantsci.2004.05.039 Occurrence Handle1:CAS:528:DC%2BD2cXmsVGis70%3D

    Article  CAS  Google Scholar 

  • V Nikiforova S Kempa M Zeh S Maimann O Kreft AP Casazza K Riedel E Tauberger R Hoefgen H Hesse (2002) ArticleTitleEngineering of cysteine and methionine biosynthesis in potato. Amino Acids 22 259–278 Occurrence Handle10.1007/s007260200013 Occurrence Handle1:CAS:528:DC%2BD38XkvFOmu7o%3D Occurrence Handle12083069

    Article  CAS  PubMed  Google Scholar 

  • VJ Nikiforova B Gakiere S Kempa M Adamik L Willmitzer H Hesse R Hoefgen (2004) ArticleTitleTowards dissecting nutrient metabolism in plants: a systems biology case study on sulphur metabolism. J Exp Bot 55 1861–1870 Occurrence Handle10.1093/jxb/erh177 Occurrence Handle1:CAS:528:DC%2BD2cXntFaisLY%3D Occurrence Handle15208339

    Article  CAS  PubMed  Google Scholar 

  • F Olea A Perez-Garcia FR Canton ME Rivera R Canas C Avila FM Cazorla FM Canovas A de Vicente (2004) ArticleTitleUp-regulation and localization of asparagine synthetase in tomato leaves infected by the bacterial pathogen Pseudomonas syringae. Plant Cell Physiol 45 770–780 Occurrence Handle10.1093/pcp/pch092 Occurrence Handle1:CAS:528:DC%2BD2cXltlWrurw%3D Occurrence Handle15215512

    Article  CAS  PubMed  Google Scholar 

  • R Omi M Goto I Miyahara H Mizuguchi H Hayashi H Kagamiyama K Hirotsu (2003) ArticleTitleCrystal structures of threonine snthase from Thermus thermophilus HB8 – Conformational change, substrate recognition, and mechanism. J Biol Chem 278 46035–46045 Occurrence Handle10.1074/jbc.M308065200 Occurrence Handle1:CAS:528:DC%2BD3sXosl2itbg%3D Occurrence Handle12952961

    Article  CAS  PubMed  Google Scholar 

  • SS Pang LW Guddat RG Duggleby (2004) ArticleTitleCrystallization of Arabidopsis thaliana acetohydroxyacid synthase in complex with the sulfonylurea herbicide chlorimuron ethyl. Acta Crystallogr D 60 153–155 Occurrence Handle1:STN:280:DC%2BD3sngtFWksg%3D%3D Occurrence Handle14684914

    CAS  PubMed  Google Scholar 

  • S Paris PM Wessel R Dumas (2002a) ArticleTitleOverproduction, purification, and characterization of recombinant bifunctional threonine-sensitive aspartate kinase-homoserine dehydrogenase from Arabidopsis thaliana. Prot Express Purif 24 105–110 Occurrence Handle1:CAS:528:DC%2BD38XntlOrug%3D%3D

    CAS  Google Scholar 

  • S Paris PM Wessel R Dumas (2002b) ArticleTitleOverproduction, purification, and characterization of recombinant aspartate semialdehyde dehydrogenase from Arabidopsis thaliana. Prot Express Purif 24 99–104 Occurrence Handle1:CAS:528:DC%2BD38XntlOrtA%3D%3D

    CAS  Google Scholar 

  • S Paris C Viemon G Curien R Dumas (2003) ArticleTitleMechanism of control of Arabidopsis thaliana aspartate kinase-homoserine dehydrogenase by threonine. J Biol Chem 278 5361–5366 Occurrence Handle10.1074/jbc.M207379200 Occurrence Handle1:CAS:528:DC%2BD3sXhtVKlurY%3D Occurrence Handle12435751

    Article  CAS  PubMed  Google Scholar 

  • C Pinheiro JA Passarinho CP Ricardo (2004) ArticleTitleEffect of drought and rewatering on the metabolism of Lupinus albus organs. J Plant Physiol 161 1203–1210 Occurrence Handle10.1016/j.jplph.2004.01.016 Occurrence Handle1:CAS:528:DC%2BD2MXhvFegtQ%3D%3D Occurrence Handle15602812

    Article  CAS  PubMed  Google Scholar 

  • A Prahl M Pazgier M Hejazi W Lockau J Lubkowski (2004) ArticleTitleStructure of the isoaspartyl peptidase with L-asparaginase activity from Escherichia coli. Acta Crystallogr D 60 1173–1176 Occurrence Handle10.1107/S0907444904003403 Occurrence Handle15159592

    Article  PubMed  Google Scholar 

  • S Ravanel B Gakiere D Job R Douce (1998) ArticleTitleThe specific features of methionine biosynthesis and metabolism in plants. Proc Natl Acad Sci USA 95 7805–7812 Occurrence Handle10.1073/pnas.95.13.7805 Occurrence Handle1:CAS:528:DyaK1cXktFCgsb8%3D Occurrence Handle9636232

    Article  CAS  PubMed  Google Scholar 

  • S Ravanel MA Block P Rippert S Jabrin G Curien F Rebeille R Douce (2004) ArticleTitleMethionine metabolism in plants: chloroplast are autonomous for de novo methionine synthesis and can import S-adenosylmethionine from the cytosol. J Biol Chem 279 22548–22557 Occurrence Handle10.1074/jbc.M313250200 Occurrence Handle1:CAS:528:DC%2BD2cXjvF2rtLc%3D Occurrence Handle15024005

    Article  CAS  PubMed  Google Scholar 

  • SE Rognes PJ Lea BJ Miflin (1980) ArticleTitleS-adenosylmethionine – a novel regulator of aspartate kinase. Nature 287 357–359 Occurrence Handle10.1038/287357a0 Occurrence Handle1:CAS:528:DyaL3MXislelsg%3D%3D Occurrence Handle6252474

    Article  CAS  PubMed  Google Scholar 

  • SE Rognes E Dewaele SF Aas M Jacobs V Frankard (2003) ArticleTitleTranscriptional and biochemical regulation of a novel Arabidopsis thaliana bifunctional aspartate kinase-homoserine dehydrogenase gene isolated by functional complementation of a yeast hom6 mutant. Plant Mol Biol 51 281–294 Occurrence Handle10.1023/A:1021134621488 Occurrence Handle1:CAS:528:DC%2BD38Xosl2ntr0%3D Occurrence Handle12602885

    Article  CAS  PubMed  Google Scholar 

  • JG Romagni FE Dayan (2000) ArticleTitleMeasuring asparagine synthetase activity in crude plant extracts. J Agric Food Chem 48 1692–1696 Occurrence Handle10.1021/jf991006e Occurrence Handle1:CAS:528:DC%2BD3cXis1Oqur0%3D Occurrence Handle10820080

    Article  CAS  PubMed  Google Scholar 

  • A Samach D Hareven T Gutfiger S Ken-Dror E Lifschitz (1991) ArticleTitleBiosynthetic threonine deaminase gene of tomato: isolation, structure and up-regulation in floral organs. Proc Natl Acad Sci USA 88 2678–2682 Occurrence Handle1:CAS:528:DyaK3MXlslKgs7s%3D Occurrence Handle2011578

    CAS  PubMed  Google Scholar 

  • A Samach L Broday D Hareven E Lifschitz (1995) ArticleTitleExpression of an amino acid biosynthesis gene in tomato flowers: Developmental upregulation and MeJA response are parenchyma-specific and mutually compatible. Plant J 8 391–406 Occurrence Handle10.1046/j.1365-313X.1995.08030391.x Occurrence Handle1:CAS:528:DyaK2MXos1Clt7o%3D Occurrence Handle7550377

    Article  CAS  PubMed  Google Scholar 

  • C Sarrobert MC Thibaud P Contard-David S Gineste N Bechtold C Robaglia L Nussaume (2000) ArticleTitleIdentification of an Arabidopsis thaliana mutant accumulating threonine resulting from mutation in a new dihydrodipicolinate synthase gene. Plant J 24 357–367 Occurrence Handle10.1046/j.1365-313x.2000.00884.x Occurrence Handle1:CAS:528:DC%2BD3cXosleju7w%3D Occurrence Handle11069709

    Article  CAS  PubMed  Google Scholar 

  • CJ Schultz M Hsu B Miesak GM Coruzzi (1998) ArticleTitleArabidopsis mutants define an in vivo role for isoenzymes of aspartate aminotransferase in plant nitrogen assimilation. Genetics 149 491–499 Occurrence Handle1:CAS:528:DyaK1cXks1ehs74%3D Occurrence Handle9611168

    CAS  PubMed  Google Scholar 

  • JM Shaver DC Bittel JM Sellner DA Frisch DA Somers BG Gengenbach (1996) ArticleTitleSingle amino acid substitutions eliminate lysine inhibition of maize dihydrodipicolinate synthase. Proc Natl Acad Sci USA 93 1962–1966 Occurrence Handle10.1073/pnas.93.5.1962 Occurrence Handle1:CAS:528:DyaK28XhsFartL0%3D Occurrence Handle8700867

    Article  CAS  PubMed  Google Scholar 

  • O Shaul G Galili (1992a) ArticleTitleIncreased lysine synthesis in tobacco plants that express high levels of bacterial dihydrodipicolinate synthase in their chloroplasts. Plant J 2 203–209 Occurrence Handle10.1111/j.1365-313X.1992.00203.x Occurrence Handle1:CAS:528:DyaK38XkvVKqtLk%3D

    Article  CAS  Google Scholar 

  • O Shaul G Galili (1992b) ArticleTitleThreonine overproduction in transgenic tobacco plants expressing a mutant desensitized aspartate kinase of Escherichia coli. Plant Physiol 100 1157–1163 Occurrence Handle1:CAS:528:DyaK3sXhslWksw%3D%3D

    CAS  Google Scholar 

  • O Shaul G Galili (1993) ArticleTitleConcerted regulation of lysine and threonine synthesis in tobacco plants expressing bacterial feedback-insensitive aspartate kinase and dihydrodipicolinate synthase. Plant Mol Biol 23 759–768 Occurrence Handle10.1007/BF00021531 Occurrence Handle1:CAS:528:DyaK2cXltVaksg%3D%3D Occurrence Handle8251629

    Article  CAS  PubMed  Google Scholar 

  • B Shen CJ Li MC Tarczynski (2002) ArticleTitleHigh free-methionine and decreased lignin content result from a mutation in the Arabidopsis S-adenosyl-L-methionine synthetase 3 gene. Plant J 29 371–380 Occurrence Handle10.1046/j.1365-313X.2002.01221.x Occurrence Handle1:CAS:528:DC%2BD38XhvFOitLs%3D Occurrence Handle11844113

    Article  CAS  PubMed  Google Scholar 

  • P Simier P Delavault E Demarsy JB Pouvreau K Pageau B Le Bizec A Fer P Thalouarn (2005) ArticleTitleCharacterization of an unusually regulated gene encoding asparagine synthetase in the parasitic plant Striga hermonthica (Scrophulariaceae). Physiol Plant 123 9–20 Occurrence Handle10.1111/j.1399-3054.2004.00438.x Occurrence Handle1:CAS:528:DC%2BD2MXhtFeqs7o%3D

    Article  CAS  Google Scholar 

  • Singh BK (1999) Plant amino acids: biochemistry and biotechnology. Marcel Dekker, New York

  • L Sodek PJ Lea (1993) ArticleTitleAsparaginase from the testa of developing lupin and peas seeds. Phytochemistry 34 51–56 Occurrence Handle10.1016/S0031-9422(00)90781-7 Occurrence Handle1:CAS:528:DyaK2cXkvVGqtg%3D%3D

    Article  CAS  Google Scholar 

  • L Sodek CM Wilson (1970) ArticleTitleIncorporation of leucine-C14 into protein in the developing of normal and opaque-2 corn. Arch Biochem Biophys 140 29–38 Occurrence Handle10.1016/0003-9861(70)90006-8 Occurrence Handle1:CAS:528:DyaE3cXltFOhtL0%3D Occurrence Handle5460182

    Article  CAS  PubMed  Google Scholar 

  • N Sreenivasulu L Altschmied R Panitz U Hahnel W Michalek W Weschke U Wobus (2002) ArticleTitleIdentification of genes specifically expressed in maternal and filial tissues of barley caryopses: a cDNA array analysis. Mol Genet Genomics 266 758–767 Occurrence Handle1:CAS:528:DC%2BD38XjtlWhsb4%3D Occurrence Handle11810249

    CAS  PubMed  Google Scholar 

  • C Steegborn B Laber A Messerschmidt R Huber T Clausen (2001) ArticleTitleCrystal structures of cystathionine γ-synthase inhibitor complexes rationalize the increase affinity of a novel inhibitor. J Biol Chem 311 789–801 Occurrence Handle1:CAS:528:DC%2BD3MXmtFGgt7w%3D

    CAS  Google Scholar 

  • Stepansky A, Less H, Angelovici R, Aharon R, Zhu X, Galili G (2006) Lysine catabolism, an effective versatile regulator of lysine level in plants. Amino Acids 30 (in press)

  • Steward GR, Larher F (1980) Accumulation of amino acids and related compounds in relation to environmental stress. In: Miflin BJ (ed) The biochemistry of plants, vol 5: amino acids and derivatives. Academic Press, New York, pp 609–635

  • A Sule F Vanrobaeys G Hajos J Van Beeumen B Devreese (2004) ArticleTitleProteomic analysis of small heat shock protein isoforms in barley shoots. Phytochemistry 65 1853–1863 Occurrence Handle10.1016/j.phytochem.2004.03.030 Occurrence Handle1:CAS:528:DC%2BD2cXmtVequ7s%3D Occurrence Handle15276443

    Article  CAS  PubMed  Google Scholar 

  • S Tan RR Evans ML Dahmer BK Singh DL Shaner (2004) ArticleTitleImidazolinone-tolerant crops: history, current status and future. Pest Manage Sci 61 246–257

    Google Scholar 

  • GL Tang G Galili (2004) ArticleTitleUsing RNAi to improve plant nutritional value: from mechanism to application. Trends Biotechnol 22 463–469 Occurrence Handle10.1016/j.tibtech.2004.07.009 Occurrence Handle1:CAS:528:DC%2BD2cXntFCjt7Y%3D Occurrence Handle15331227

    Article  CAS  PubMed  Google Scholar 

  • GL Tang JX Zhu R Amir IB Zchori G Galili (1997) ArticleTitleCloning and expression of an Arabidopsis thaliana cDNA encoding a monofunctional aspartate kinase homologous to the lysine-sensitive enzyme of Escherichia coli. Plant Mol Biol 34 287–293 Occurrence Handle10.1023/A:1005849228945 Occurrence Handle1:CAS:528:DyaK2sXktlWls7k%3D Occurrence Handle9207844

    Article  CAS  PubMed  Google Scholar 

  • GL Tang XH Zhu B Gakiere H Levanony A Kahana G Galili (2002) ArticleTitleThe bifunctional LKR/SDH locus of plants also encodes a highly active monofunctional lysine-ketoglutarate reductase using a polyadenylation signal located within an intron. Plant Physiol 130 147–154 Occurrence Handle10.1104/pp.005660 Occurrence Handle1:CAS:528:DC%2BD38XntFOrsbs%3D Occurrence Handle12226495

    Article  CAS  PubMed  Google Scholar 

  • N Tewari-Singh J Sen H Kiesecker VS Reddy HJ Jacobsen S Guha-Mukherjee (2004) ArticleTitleUse of a herbicide or lysine plus threonine for non-antibiotic selection of transgenic chickpea. Plant Cell Rep 22 576–583 Occurrence Handle10.1007/s00299-003-0730-6 Occurrence Handle1:CAS:528:DC%2BD2cXhsFWqu7Y%3D Occurrence Handle14749891

    Article  CAS  PubMed  Google Scholar 

  • K Thomazeau G Curien R Dumas V Biou (2001) ArticleTitleCrystal structure of threonine synthase from Arabidopsis thaliana. Prot Sci 10 638–648 Occurrence Handle1:CAS:528:DC%2BD3MXit12ms7c%3D

    CAS  Google Scholar 

  • K Thomazeau R Dumas F Halgand E Forest R Douce V Biou (2000) ArticleTitleStructure of spinach acetohydroxyacid isomeroreductase complexed with its reaction product dihydroxymethylvalerate, manganese and (phospho)-ADP-ribose. Acta Crystallogr D 56 389–397 Occurrence Handle10.1107/S0907444900001694 Occurrence Handle10739911

    Article  PubMed  Google Scholar 

  • KE Thum DE Shasha LV Lejay GM Coruzzi (2003) ArticleTitleLight and carbon signalling pathways. Modelling circuits of interactions. Plant Physiol 132 440–452 Occurrence Handle10.1104/pp.103.022780 Occurrence Handle1:CAS:528:DC%2BD3sXkslersLw%3D Occurrence Handle12805577

    Article  CAS  PubMed  Google Scholar 

  • S Tunca RI Yilmaz J Piret P Liras G Ozcengiz (2004) ArticleTitleCloning, characterization and heterologous expression of the aspartokinase and aspartate semialdehyde dehydrogenase genes of cephamycin C-producer Streptomyces clavuligeurs. Res Microbiol 155 525–534 Occurrence Handle10.1016/j.resmic.2004.03.007 Occurrence Handle1:CAS:528:DC%2BD2cXmslekt78%3D Occurrence Handle15313252

    Article  CAS  PubMed  Google Scholar 

  • VVS Tyagi RR Henke WR Farkas (1982) ArticleTitleOccurrence of diaminopimelate epimerase in maize. Biochim Biophys Acta 719 363–369 Occurrence Handle1:CAS:528:DyaL3sXjtFCrsg%3D%3D

    CAS  Google Scholar 

  • VVS Tyagi RR Henke WR Farkas (1983) ArticleTitlePartial purification and characterisation of dihydrodipicolinate reductase from maize. Plant Physiol 73 687–691 Occurrence Handle1:CAS:528:DyaL2cXjtFejtw%3D%3D

    CAS  Google Scholar 

  • G Van-Heeke SM Schuster (1989) ArticleTitleThe N-terminal cysteine of human asparagine synthetase is essential for glutamine-dependent activity. J Biol Chem 264 19475–19477 Occurrence Handle1:CAS:528:DyaL1MXlvFShurg%3D Occurrence Handle2573597

    CAS  PubMed  Google Scholar 

  • T Van Huysen S Abdel-Ghany KL Hale D LeDuc N Terry EAH Pilon-Smits (2003) ArticleTitleOverexpression of cystathionine-γ-synthase enhances selenium volatilization in Brassica juncea. Planta 218 71–78 Occurrence Handle10.1007/s00425-003-1070-z Occurrence Handle1:CAS:528:DC%2BD3sXovV2lt7Y%3D Occurrence Handle14618405

    Article  CAS  PubMed  Google Scholar 

  • M Vauterin V Frankard M Jacobs (1999) ArticleTitleThe Arabidopsis thaliana dhdps gene encoding dihydrodipicolinate synthase, key enzyme of lysine biosynthesis, is expressed in a cell-specific manner. Plant Mol Biol 39 695–708 Occurrence Handle10.1023/A:1006132428623 Occurrence Handle1:CAS:528:DyaK1MXjtFSqsrc%3D Occurrence Handle10350084

    Article  CAS  PubMed  Google Scholar 

  • M Vauterin V Frankard M Jacobs (2000) ArticleTitleFunctional rescue of a bacterial dapA auxotroph with a plant cDNA library selects for mutant clones encoding a feedback-insensitive dihydrodipicolinate synthase. Plant J 21 239–248 Occurrence Handle10.1046/j.1365-313x.2000.00668.x Occurrence Handle1:CAS:528:DC%2BD3cXisValu7w%3D Occurrence Handle10758475

    Article  CAS  PubMed  Google Scholar 

  • E Vincze JM Reeves E Lamping KJF Farnden PHS Reynolds (1994) ArticleTitleRepression of the L-asparaginase gene during nodule development in Lupinus angustifolius. Plant Mol Biol 26 303–311 Occurrence Handle10.1007/BF00039541 Occurrence Handle1:CAS:528:DyaK2MXitVKntbc%3D Occurrence Handle7948878

    Article  CAS  PubMed  Google Scholar 

  • YH Wang DF Garvin LV Kochian (2001) ArticleTitleNitrate-induced genes in tomato roots. Array analysis reveals novel genes that may play a role in nitrogen nutrition. Plant Physiol 127 345–359 Occurrence Handle1:CAS:528:DC%2BD3MXmvFCrtbo%3D Occurrence Handle11553762

    CAS  PubMed  Google Scholar 

  • R Wang M Okamoto XJ Xing NM Crawford (2003) ArticleTitleMicroarray analysis of the nitrate response in Arabidopsis roots and shoots reveals over 1,000 rapidly responding genes and new linkages to glucose, trehalose-6-Phosphate, iron, and sulfate metabolism. Plant Physiol 132 556–567 Occurrence Handle1:CAS:528:DC%2BD3sXkslersbw%3D Occurrence Handle12805587

    CAS  PubMed  Google Scholar 

  • RN Waterhouse AJ Smyth A Massonneau IM Prosser DT Clarkson (1996) ArticleTitleMolecular cloning and characterisation of asparagine synthetase from Lotus japonicus: Dynamics of asparagine synthesis in N-sufficient conditions. Plant Mol Biol 30 883–897 Occurrence Handle10.1007/BF00020801 Occurrence Handle1:CAS:528:DyaK28XjsFGltLw%3D Occurrence Handle8639748

    Article  CAS  PubMed  Google Scholar 

  • PM Wessel V Biou R Dorcc R Dumas (1998) ArticleTitleA loop deletion in the plant acetohydroxy acid isomeroreductase homodimer generates an active monomer with reduced stability and altered affinity. Biochemistry 37 12753–12760 Occurrence Handle10.1021/bi980411g Occurrence Handle1:CAS:528:DyaK1cXlsVelt78%3D Occurrence Handle9737852

    Article  CAS  PubMed  Google Scholar 

  • PM Wessel E Graciet R Douce R Dumas (2000) ArticleTitleEvidence for two effector-binding sites in threonine deaminase by site-directed mutagenesis, kinetic, and binding experiments. Biochemistry 39 15136–15143 Occurrence Handle10.1021/bi001625c Occurrence Handle1:CAS:528:DC%2BD3cXotVaksbc%3D Occurrence Handle11106492

    Article  CAS  PubMed  Google Scholar 

  • BJ Wilson AC Gray BF Matthews (1991) ArticleTitleBifunctional protein in carrot contains both aspartokinase and homoserine dehydrogenase activities. Plant Physiol 97 1323–1328 Occurrence Handle1:CAS:528:DyaK38XnvFSgtw%3D%3D

    CAS  Google Scholar 

  • HK Wong HK Chan GM Coruzzi HM Lam (2004) ArticleTitleCorrelation of ASN2 gene expression with ammonium metabolism in Arabidopsis. Plant Physiol 134 332–338 Occurrence Handle10.1104/pp.103.033126 Occurrence Handle1:CAS:528:DC%2BD2cXhtVansr4%3D Occurrence Handle14671018

    Article  CAS  PubMed  Google Scholar 

  • Z Yang LM Rogers Y Song W Guo PE Kolattukudy (2005) ArticleTitleHomoserine and asparagine are host signals that trigger in planta expression of a pathogenesis gene in Nectria haematococca. Proc Natl Acad Sci USA 102 41197–41202

    Google Scholar 

  • Y Yoshioka S Kurei Y Machida (2001) ArticleTitleIdentification of a monofunctional aspartate kinase gene of Arabidopsis thaliana with spatially and temporally regulated expression. Genes Genet Syst 76 189–198 Occurrence Handle10.1266/ggs.76.189 Occurrence Handle1:CAS:528:DC%2BD3MXntFagtb8%3D Occurrence Handle11569502

    Article  CAS  PubMed  Google Scholar 

  • M Zeh AP Casazza O Kreft U Roessner K Bieberich L Willmitzer R Hoefgen H Hesse (2001) ArticleTitleAntisense inhibition of threonine synthase leads to high methionine content in transgenic potato plants. Plant Physiol 127 792–802 Occurrence Handle10.1104/pp.127.3.792 Occurrence Handle1:CAS:528:DC%2BD3MXos1Kntbg%3D Occurrence Handle11706163

    Article  CAS  PubMed  Google Scholar 

  • M Zeh G Leggewie R Hoefgen H Hesse (2002) ArticleTitlecloning and characterization of a cDNA encoding a cobalamin-independent methionine synthase from potato (Solanum tuberosum L.). Plant Mol Biol 48 255–265 Occurrence Handle10.1023/A:1013333303554 Occurrence Handle1:CAS:528:DC%2BD38XhtlWku7c%3D Occurrence Handle11855727

    Article  CAS  PubMed  Google Scholar 

  • T Zhou M Daugherty NV Grishin AL Osterman H Zhang (2000) ArticleTitleStructure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily. Structure 8 1247–1257 Occurrence Handle10.1016/S0969-2126(00)00533-5 Occurrence Handle1:CAS:528:DC%2BD3MXhtFentrk%3D Occurrence Handle11188689

    Article  CAS  PubMed  Google Scholar 

  • XH Zhu G Galili (2003) ArticleTitleIncreased lysine synthesis coupled with a knockout of its catabolism synergistically boosts lysine content and also transregulates the metabolism of other amino acids in Arabidopsis seeds. Plant Cell 15 845–853 Occurrence Handle10.1105/tpc.009647 Occurrence Handle1:CAS:528:DC%2BD3sXjtFSlsLg%3D Occurrence Handle12671081

    Article  CAS  PubMed  Google Scholar 

  • XH Zhu GL Tang G Galili (2000) ArticleTitleCharacterization of the two saccharopine dehydrogenase isozymes of lysine catabolism encoded by the single composite at AtLKR/SDH locus of arabidopsis. Plant Physiol 124 1363–1371 Occurrence Handle1:CAS:528:DC%2BD3cXotlWqsL8%3D Occurrence Handle11080311

    CAS  PubMed  Google Scholar 

  • XH Zhu GL Tang F Granier D Bouchez G Galili (2001) ArticleTitleA T-DNA insertion knockout of the bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase gene elevates lysine levels in arabidopsis seeds. Plant Physiol 126 1539–1545 Occurrence Handle1:CAS:528:DC%2BD3MXlvFOju70%3D Occurrence Handle11500552

    CAS  PubMed  Google Scholar 

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Azevedo, R., Lancien, M. & Lea, P. The aspartic acid metabolic pathway, an exciting and essential pathway in plants. Amino Acids 30, 143–162 (2006). https://doi.org/10.1007/s00726-005-0245-2

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