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Conditioning training and retrieval increase phospholipase A2 activity in the cerebral cortex of rats

  • Basic Neurosciences, Genetics and Immunology - Original Article
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Abstract

In rats, phospholipase A2 (PLA2) activity was found to be increased in the hippocampus immediately after training and retrieval of a contextual fear conditioning paradigm (step-down inhibitory avoidance [IA] task). In the present study we investigated whether PLA2 is also activated in the cerebral cortex of rats in association with contextual fear learning and retrieval. We observed that IA training induces a rapid (immediately after training) and long-lasting (3 h after training) activation of PLA2 in both frontal and parietal cortices. However, immediately after retrieval (measured 24 h after training), PLA2 activity was increased just in the parietal cortex. These findings suggest that PLA2 activity is differentially required in the frontal and parietal cortices for the mechanisms of contextual learning and retrieval. Because reduced brain PLA2 activity has been reported in Alzheimer disease, our results suggest that stimulation of PLA2 activity may offer new treatment strategies for this disease.

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Acknowledgments

The present study was financially supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP; Projects 02/13633-7, 05/52896-1, 05/52897-8). The Laboratory of Neuroscience receives financial support from the Associação Beneficente Alzira Denise Hertzog da Silva (ABADHS).

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  1. Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Doutor Ovídio Pires de Campos, 785, CEP 05403-010, São Paulo, SP, Brazil

    E. L. Schaeffer, L. Zorrón Pu, D. A. M. Gagliotti & W. F. Gattaz

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  1. E. L. Schaeffer
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Schaeffer, E.L., Zorrón Pu, L., Gagliotti, D.A.M. et al. Conditioning training and retrieval increase phospholipase A2 activity in the cerebral cortex of rats. J Neural Transm 116, 41–50 (2009). https://doi.org/10.1007/s00702-008-0133-5

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