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Damage to oligodendrocytes in the striatum after MPTP neurotoxicity in mice

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Summary

We investigated the alteration of oligodendrocytes in comparison with that of astrocytes and microglia in the mouse striatum after MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropridine) treatment under the same conditions using Western blot analysis and Immunohistochemistry. In our Western blot analysis, four administrations of MPTP at 2-h intervals to mice produced the remarkable loss of TH (tyrosine hydroxylase) protein levels in the striatum after 3 and 7 days. In contrast, GFAP (glial fibrillary acidic protein) and Iba-1 protein in the striatum showed a significant increase of GFAP and Iba-1 protein levels 3 and 7 days after MPTP treatment. On the other hand, the levels of CNPase (2′, 3′-cyclic nucleotide 3′-phosphodiesterase) protein were decreased significantly in the striatum 3 and 7 days after MPTP treatment. In our immunohistochemical study, a significant decrease in the area of expression of CNPase-positive profiles was observed in the striatum 3 and 7 days after MPTP treatment.

These results demonstrate that oligodendrocytes in the striatum are damaged after MPTP treatment. Thus our present findings provide valuable information for the pathogenesis of Parkinson’s disease.

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Authors and Affiliations

  1. Department of Neurobiology and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima, Japan

    S. Takagi, N. Hayakawa, H. Kimoto & T. Araki

  2. Organized Center of Clinical Medicine, Department of Neurology, International University of Health and Welfare, Tochigi, Japan

    H. Kato

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  1. S. Takagi
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  2. N. Hayakawa
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  3. H. Kimoto
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  4. H. Kato
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  5. T. Araki
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Takagi, S., Hayakawa, N., Kimoto, H. et al. Damage to oligodendrocytes in the striatum after MPTP neurotoxicity in mice. J Neural Transm 114, 1553–1557 (2007). https://doi.org/10.1007/s00702-007-0790-9

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