European Archives of Oto-Rhino-Laryngology

, Volume 273, Issue 6, pp 1533–1541

(Chemo)radiotherapy after laser microsurgery and selective neck dissection for pN2 head and neck cancer

  • Hendrik Andreas Wolff
  • Friedrich Ihler
  • Nina Zeller
  • Christian Welz
  • Klaus Jung
  • Martin Canis
  • Wolfgang Steiner
Head and Neck

DOI: 10.1007/s00405-015-3619-4

Cite this article as:
Wolff, H.A., Ihler, F., Zeller, N. et al. Eur Arch Otorhinolaryngol (2016) 273: 1533. doi:10.1007/s00405-015-3619-4

Abstract

This study analyzed the efficacy of transoral laser microsurgery and postoperative (chemo) radiotherapy (CRT) for head and neck squamous cell carcinoma. Between 1987 and 2007, 318 patients with pN2 neck disease were included. Seventy-three patients received laser resection and neck dissection alone, 154 postoperative radiotherapy, and 91 postoperative (C)RT. Mean follow-up was 58.2 ± 51.2 months, and locoregional control was significantly better after postoperative (C)RT (surgery alone: 42 %, radiotherapy: 57 %, CRT: 59 %; p < 0.01). Postoperative (C)RT did not have a significant impact on disease-specific survival (DSS) (surgery alone: 55 %, radiotherapy alone: 60 %, CRT: 64 %; p = 0.36). Fifty-seven patients (17.92 %) developed distant metastases, and 39 patients (12.26 %) presented with secondary malignancies, with no significant differences found between the treatment groups. Postoperative (C)RT significantly improved locoregional control, but had no significant effect on DSS because of high rates of secondary malignancies and distant metastases. Reduced radicality in combination with an effective screening might improve prognosis and quality of life of these patients.

Keywords

HNSCC pN2 (Chemo)radiotherapy Transoral laser microsurgery Selective neck dissection 

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Hendrik Andreas Wolff
    • 1
  • Friedrich Ihler
    • 2
  • Nina Zeller
    • 2
  • Christian Welz
    • 2
  • Klaus Jung
    • 3
  • Martin Canis
    • 2
  • Wolfgang Steiner
    • 2
  1. 1.Department of Radiotherapy and Radiation OncologyUniversity of GöttingenGöttingenGermany
  2. 2.Department of Otorhinolaryngology, Head and Neck SurgeryUniversity of GöttingenGöttingenGermany
  3. 3.Department of Medical StatisticsUniversity of GöttingenGöttingenGermany

Personalised recommendations