Abstract
Objective
To evaluate the usefulness of FDG PET/CT to differentiate malignant endobronchial lesions with distal atelectasis from benign bronchial stenosis.
Methods
This retrospective study reviewed 84 patients who underwent contrast-enhanced chest CT and then PET/CT and had histological (n = 81) or follow-up imaging (n = 3) confirmation. Two chest radiologists reviewed initial chest CT and determined endobronchial lesions to be malignant or benign. Two nuclear medicine physicians reviewed PET/CT for FDG uptake at the obstruction site and measured SUV. Malignancy was considered when increased FDG uptake was seen in the obstruction site, regardless of FDG within the atelectatic lung.
Results
The sensitivity, specificity and accuracy of chest CT was 95%, 48% and 84%, compared with 95%, 91% and 94% for PET/CT. Benign obstructive lesions showed statistically lower FDG uptake than malignant obstructions (benign SUV 2.5 ± 0.84; malignant SUV 11.8 ± 5.95, p < 0.001). ROC analysis showed an SUV cut-off value of 3.4 with highest sensitivity of 94% and specificity of 91%.
Conclusion
Increased FDG PET/CT uptake at the obstruction site indicates a high probability of malignancy, while benign lesions show low FDG uptake. Careful evaluation of FDG uptake pattern at the obstruction site is helpful in the differentiation between benign and malignant endobronchial lesions.
Similar content being viewed by others
References
Woodring JH, Reed JC (1996) Types and mechanisms of pulmonary atelectasis. J Thorac Imaging 11:92–108
Burke M, Fraser R (1988) Obstructive pneumonitis: a pathologic and pathogenetic reappraisal. Radiology 166:699–704
Woodring JH (1988) Determining the cause of pulmonary atelectasis: a comparison of plain radiography and CT. AJR Am J Roentgenol 150:757–763
Naidich DP, McCauley DI, Khouri NF, Leitman BS, Hulnick DH, Siegelman SS (1983) Computed tomography of lobar collapse: 1. Endobronchial obstruction. J Comput Assist Tomogr 7:745–757
Molina PL, Hiken JN, Glazer HS (1996) Imaging evaluation of obstructive atelectasis. J Thorac Imaging 11:176–186
Wilson RW, Frazier AA (1998) Pathological-radiological correlations: pathological and radiological correlation of endobronchial neoplasms: part II, malignant tumors. Ann Diagn Pathol 2:31–34
Naidich DP (1990) CT/MR correlation in the evaluation of tracheobronchial neoplasia. Radiol Clin North Am 28:555–571
Wilson RW, Kirejczyk W (1997) Pathological and radiological correlation of endobronchial neoplasms: Part I, Benign tumors. Ann Diagn Pathol 1:31–46
Prince JS, Duhamel DR, Levin DL, Harrell JH, Friedman PJ (2002) Nonneoplastic lesions of the tracheobronchial wall: radiologic findings with bronchoscopic correlation. Radiographics 22 Spec No: S215–30
Kim Y, Lee KS, Yoon JH et al (1997) Tuberculosis of the trachea and main bronchi: CT findings in 17 patients. AJR Am J Roentgenol 168:1051–1056
Ko JM, Jung JI, Park SH et al (2006) Benign tumors of the tracheobronchial tree: CT-pathologic correlation. AJR Am J Roentgenol 186:1304–1313
Henschke CI, Davis SD, Auh Y et al (1987) Detection of bronchial abnormalities: comparison of CT and bronchoscopy. J Comput Assist Tomogr 11:432–435
Mayr B, Ingrisch H, Haussinger K, Huber RM, Sunder-Plassmann L (1989) Tumors of the bronchi: role of evaluation with CT. Radiology 172:647–652
Naidich DP, Lee JJ, Garay SM, McCauley DI, Aranda CP, Boyd AD (1987) Comparison of CT and fiberoptic bronchoscopy in the evaluation of bronchial disease. AJR Am J Roentgenol 148:1–7
Heitzman ER, Markarian B, Raasch BN, Carsky EW, Lane EJ, Berlow ME (1982) Pathways of tumor spread through the lung: radiologic correlations with anatomy and pathology. Radiology 144:3–14
Grenier PA, Beigelman-Aubry C, Brillet PY (2009) Nonneoplastic tracheal and bronchial stenoses. Radiol Clin North Am 47:243–260
Park CM, Goo JM, Lee HJ, Kim MA, Lee CH, Kang MJ (2009) Tumors in the tracheobronchial tree: CT and FDG PET features. Radiographics 29:55–71
Emerson GL, Emerson MS, Sherwood CE (1959) The natural history of carcinoma of the lung. J Thorac Surg 37:291–304
Gerbaudo VH, Julius B (2007) Anatomo-metabolic characteristics of atelectasis in F-18 FDG-PET/CT imaging. Eur J Radiol 64:401–405
Kisala JM, Ayala A, Stephan RN, Chaudry IH (1993) A model of pulmonary atelectasis in rats: activation of alveolar macrophage and cytokine release. Am J Physiol 264:R610–614
Nestle U, Walter K, Schmidt S et al (1999) 18F-deoxyglucose positron emission tomography (FDG-PET) for the planning of radiotherapy in lung cancer: high impact in patients with atelectasis. Int J Radiat Oncol Biol Phys 44:593–597
Tateishi U, Hasegawa T, Seki K, Terauchi T, Moriyama N, Arai Y (2006) Disease activity and 18F-FDG uptake in organising pneumonia: semi-quantitative evaluation using computed tomography and positron emission tomography. Eur J Nucl Med Mol Imaging 33:906–912
Park HJ, Park SH, Im SA, Kim YK, Lee KY (2008) CT differentiation of anthracofibrosis from endobronchial tuberculosis. AJR Am J Roentgenol 191:247–251
Lee KS, Im JG (1995) CT in adults with tuberculosis of the chest: characteristic findings and role in management. AJR Am J Roentgenol 164:1361–1367
Chung HS, Lee JH (2000) Bronchoscopic assessment of the evolution of endobronchial tuberculosis. Chest 117:385–392
Jeong YJ, Lee KS (2008) Pulmonary tuberculosis: up-to-date imaging and management. AJR Am J Roentgenol 191:834–844
Ung YC, Maziak DE, Vanderveen JA et al (2007) 18Fluorodeoxyglucose positron emission tomography in the diagnosis and staging of lung cancer: a systematic review. J Natl Cancer Inst 99:1753–1767
Englmeier KH, Seemann MD (2008) Multimodal virtual bronchoscopy using PET/CT images. Comput Aided Surg 13:106–113
Erasmus JJ, McAdams HP, Patz EF Jr, Coleman RE, Ahuja V, Goodman PC (1998) Evaluation of primary pulmonary carcinoid tumors using FDG PET. AJR Am J Roentgenol 170:1369–1373
Nakamura R, Ishikawa S, Sakai M, Goto Y, Minami Y (2009) Increased fluorodeoxyglucose-uptake in positron emission tomography with an endobronchial schwannoma occluding the left main stem bronchus. J Thorac Oncol 4:1183–1184
Pasic A, Brokx HA, Comans EF et al (2005) Detection and staging of preinvasive lesions and occult lung cancer in the central airways with 18F-fluorodeoxyglucose positron emission tomography: a pilot study. Clin Cancer Res 11:6186–6189
Seemann MD, Schaefer JF, Englmeier KH (2007) Virtual positron emission tomography/computed tomography-bronchoscopy: possibilities, advantages and limitations of clinical application. Eur Radiol 17:709–715
Tokuyasu H, Harada T, Watanabe E et al (2008) A case of endobronchial actionomycosis evaluated by FDG-PET. Nihon Kokyuki Gakkai Zasshi 46:650–654
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Cho, A., Hur, J., Kang, W.J. et al. Usefulness of FDG PET/CT in determining benign from malignant endobronchial obstruction. Eur Radiol 21, 1077–1087 (2011). https://doi.org/10.1007/s00330-010-2006-1
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00330-010-2006-1