International Orthopaedics

, Volume 38, Issue 2, pp 387–395

Platelet-rich plasma prevents blood loss and pain and enhances early functional outcome after total knee arthroplasty: a prospective randomised controlled study

  • Aditya K. Aggarwal
  • V. S. Shashikanth
  • Neelam Marwaha
Original Paper

DOI: 10.1007/s00264-013-2136-6

Cite this article as:
Aggarwal, A.K., Shashikanth, V.S. & Marwaha, N. International Orthopaedics (SICOT) (2014) 38: 387. doi:10.1007/s00264-013-2136-6



The purpose of this study was to determine whether platelet-rich plasma (PRP) might prevent blood loss and postoperative pain and expedite wound healing following total knee arthroplasty (TKA).


Forty consecutive patients with knee arthritis who were matched for age, sex and body mass index (BMI) were randomly allocated to either receive or not receive PRP application over the wound, including capsule, medial and lateral recesses, during TKA. Postoperative haemoglobin, blood loss, blood transfusion, visual analogue scale (VAS) score, wound score, Knee Society Score (KSS) and Western Ontario and McMaster Osteoarthritis Index (WOMAC) score were recorded and evaluated.


The platelet-rich plasma and control groups comprised 17 and 23 patients, respectively. The PRP group recorded significantly less reduction in haemoglobin and need for blood transfusion (p = 0.00 and p = 0.001, respectively), experienced less pain (p = 0.00) and required fewer narcotics than the control (p = 0.00). There was significant difference in range of motion (ROM) at three months (p = 0.01), no significant difference in wound scores (p = 0.311) and significant difference in KSS and WOMAC scores at 12 weeks (p = 0.00, 0.00). However no significant difference was found at six months.


PRP has significant effect in preventing blood loss, postoperative pain and need for narcotics after TKA and has a positive effect on short-term clinical outcome.


OsteoarthritisTotal knee arthroplastyAutologous platelet-rich plasmaBlood lossPainFunctional outcome

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Aditya K. Aggarwal
    • 1
  • V. S. Shashikanth
    • 1
  • Neelam Marwaha
    • 2
  1. 1.Department of Orthopaedic SurgeryPost graduate Institute of Medical Education & ResearchChandigarhIndia
  2. 2.Department of Transfusion MedicinePost graduate institute of Medical Education & ResearchChandigarhIndia