Original Article

Cancer Immunology, Immunotherapy

, 56:905

First online:

Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cancer

  • Koji ObaAffiliated withDepartment of Epidemiological and Clinical Research Information Management, Kyoto University Graduate School of Medicine Email author 
  • , Satoshi TeramukaiAffiliated withDepartment of Clinical Trial Design and Management, Translational Research Center, Kyoto University Hospital
  • , Michiya KobayashiAffiliated withDepartment of Surgery, Kochi University
  • , Takanori MatsuiAffiliated withDepartment of Surgery, Aichi Prefectural Hospital
  • , Yasuhiro KoderaAffiliated withDepartment of Surgery, Nagoya University Graduate School of Medicine
  • , Junichi SakamotoAffiliated withYoung Leaders Program, Nagoya University Graduate School of Medicine

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Abstract

Non-specific immunopotentiators, such as polysaccharide K (PSK), also known as OK-432, induce anti-tumor effects via immunological responses. The efficacy of combination immunochemotherapy using these immunopotentiators has been examined by multiple previous studies. The survival benefits of immunochemotherapy for patients with curative resections of gastric cancers are not widely accepted. To clarify this issue, we performed a meta-analysis to evaluate the effect of immunochemotherapy on survival in patients with curative resections of gastric cancer. For this study, we compared the results of chemotherapy and immunotherapy using the biological response modifier PSK as an immunopotentiator. The meta-analysis included 8,009 patients from eight randomized controlled trials after central randomization. The overall hazard ratio for eligible patients was 0.88 (95% confidence interval, 0.79–0.98; P = 0.018) with no significant heterogeneity [χ 2(8) for heterogeneity = 11.7; P = 0.16]. The results of this meta-analysis suggest that adjuvant immunochemotherapy with PSK improves the survival of patients after curative gastric cancer resection.

Keywords

Adjuvant immunochemotherapy Gastric cancer Meta-analysis Polysaccharide K