Abstract
During the systematic screening of active compounds from marine-derived fungi, the extract of a strain of Aspergillus versicolor MF359 isolated from a marine sponge of Hymeniacidon perleve was identified for detailed chemical investigation. Three new secondary metabolites, named hemiacetal sterigmatocystin (1), acyl-hemiacetal sterigmatocystin (2), and 5-methoxydihydrosterigmatocystin (3), together with a known compound, aversin (4), were characterized. 1 represents a first structure of sterigmatocystin hemiacetal from nature. The antibacterial activities of these identified compounds were evaluated against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa. Compound 3 showed activity against S. aureus and B. subtilis with MIC values of 12.5 and 3.125 μg/mL, respectively.
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Acknowledgments
This work was supported in part by the National Program on Key Basic Research Project (973 program, 2013CB734000, 2012CB721000), the National Natural Science Foundation of China (30901849, 81102356, 81261120389, 81102369), the CAS Pillar Program (XDA04074000), the Ministry of Science and Technology of China (2011ZX11102-011-11), Genzyme, Sanofi company. L. Zhang is an Awardee of the National Distinguished Young Scholar Program in China.
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Song, F., Ren, B., Chen, C. et al. Three new sterigmatocystin analogues from marine-derived fungus Aspergillus versicolor MF359. Appl Microbiol Biotechnol 98, 3753–3758 (2014). https://doi.org/10.1007/s00253-013-5409-5
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DOI: https://doi.org/10.1007/s00253-013-5409-5