Abstract
In this study, a series of newN 2 substituted 1,2-dihydro-3H-indazol-3-ones (3a-d) as well as their condensed pyrazolo, pyridazino derivatives such as pyridazino[1,2-a]indazole-6,9,11-triones (4a-h) and 3,9-dioxo-3H,9H-pyrazolo[1,2-a]indazole (7) were synthesized. The antiinflammatory activity of some synthesized compounds was determined by carrageenan-induced rat paw edema technique using diclofenac as reference drug. The pharmacological data showed that most of the tested compounds exhibited a significant long lasting antiinflammatory activity, which in the case of compound3b was superior to that of diclofenac.
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Abouzid, K.A.M., El-Abhar, H.S. Synthesis and antiinflammatory activity of novel indazolones. Arch Pharm Res 26, 1–8 (2003). https://doi.org/10.1007/BF03179922
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DOI: https://doi.org/10.1007/BF03179922