Summary
A sesquiterpene isolated from the roots ofAristolochia indica (Linn.) was found to exert 100% interceptive activity and 91.7% anti-implantation activity in mice at a single oral dose of 100mg/kg b. wt. No toxic effect was found at the dose levels used.
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References
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A. Pakrashi, B. Chakrabarty and A. Dasgupta, Experientia32, 394 (1976).
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The authors wish to thank Dr S. C. Pakrashi and his associate Mr P. P. Ghosh Dastidar of Medicinal Chemistry Department for isolating the compound for this study. Thanks are also due to Director-General of Indian Council of Medical Research for granting a Junior Research Fellowship to C.S.
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Pakrashi, A., Shaha, C. Effect of a sesquiterpene fromAristolochia indica Linn. on fertility in female mice. Experientia 33, 1498–1499 (1977). https://doi.org/10.1007/BF01918832
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DOI: https://doi.org/10.1007/BF01918832