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Pro-fertility effects of hydroalcoholic extract of Psidium guajava leaves in female Wistar rats

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Abstract

Psidium guajava is a renowned plant used by African traditional medical practitioners because of its numerous therapeutic benefits but little is known of its positive effects on female fertility. The Pro-fertility effects of hydroalcoholic extract of Psidium guajava leaves in female Wistar rats  were investigated in the present study. Four (4) groups of five (5) rats each were used for the study. Group A is the control received” Tween 20®”. Groups B, C, and D rats received 100, 200 and 400 mg/kg body weight of the hydroalcoholic extract of P. guajava (HEPG) leaves respectively for 19 days. The rats were laparatomised on day 20 and the number of corpora lutea of pregnancy, number of live fetuses, the weight of the fetuses and placentae as well as the postcoital fertility index were recorded. Oral administration of HEPG leaves from day 1–19 significantly (P < 0.05) caused an increase in maternal body weights, average weight of the placenta, ovary, and foetus in a dose-dependent-manner in the treated groups as compared with the control group. Progressive increase in the number of pregnant rats, number of rats showing implantation, number of the live foetus and mean corpus luteum number (CLN) per female, foetal crown-rump length (FCRL), percentage of a pregnant female in each group (PPF), and fertility index (FI) in a dose-dependent-manner, when the test groups are compared to control group. The results suggest that HEPG leaves could induce positive effects on the reproductive system in female albino rats.

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Acknowledgements

We appreciate the assistance of the two Laboratory technologies: Upev Vincent and Achanya Daniel from the Department of Veterinary Physiology and Biochemistry and Veterinary Pharmacology and Toxicology respectively for their immense contribution to this work.

Funding

There was no external funding for this project. The study was funded majorly by the authors.

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Authors and Affiliations

  1. Department of Veterinary Physiology and Biochemistry, Federal University of Agriculture, P.M.B. 2373, Makurdi, Benue, Nigeria

    Saleh Adamu Abwage, Solomon Tsekohol Agu & Hyacinth Adakole Abu

  2. Department of Veterinary Pharmacology and Toxicology, Federal University of Agriculture, P.M.B. 2373, Makurdi, Benue, Nigeria

    Saganuwan Alhaji Saganuwan

Authors
  1. Saleh Adamu Abwage
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  2. Saganuwan Alhaji Saganuwan
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  3. Solomon Tsekohol Agu
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  4. Hyacinth Adakole Abu
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Correspondence to Solomon Tsekohol Agu.

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Ethical statement

Experimental rats were cared for according to standard international (NRC, 2011) and Institutional (Animal Care and Use in Research Ethics Committee of the Federal University of Agriculture, Makurdi, Nigeria) guidelines (CVM/FUAM/2020/22).

Conflict of interest

Saleh Adamu Abwage has no conflict of interest. Saganuwan Alhaji Saganuwan has no conflict of interest. Agu Solomon Tsekohol has no conflict of interest. Abu Adakole Hyacinth has no conflict of interest.

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Abwage, S.A., Saganuwan, S.A., Agu, S.T. et al. Pro-fertility effects of hydroalcoholic extract of Psidium guajava leaves in female Wistar rats. ADV TRADIT MED (ADTM) 23, 105–109 (2023). https://doi.org/10.1007/s13596-021-00579-2

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  • DOI: https://doi.org/10.1007/s13596-021-00579-2

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