Original Articles

Digestive Diseases and Sciences

, Volume 31, Issue 4, pp 343-348

Gastric emptying and gastrointestinal absorption of alcohol ingested with a meal

  • Antoine CortotAffiliated withINSERM U 54, Hôpital Saint-Lazare
  • , Gilles JobinAffiliated withINSERM U 54, Hôpital Saint-Lazare
  • , Frederic DucrotAffiliated withINSERM U 54, Hôpital Saint-Lazare
  • , Chantal AymesAffiliated withINSERM U 54, Hôpital Saint-Lazare
  • , Veronique GiraudeauxAffiliated withINSERM U 54, Hôpital Saint-Lazare
  • , Robert ModiglianiAffiliated withINSERM U 54, Hôpital Saint-Lazare

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Abstract

We have measured, by an intubation method, gastric evacuation and gastrointestinal absorption of alcohol ingested with a meal in seven healthy nonalcoholic subjects. A homogenized meal containing [14C]PEG and ethanol (1 g/kg body wt) was given intragastrically while saline containing [57CO]vitamin B12 was perfused into the duodenum. Of the ingested alcohol, 39.4±4.1% was absorbed through the stomach wall during the first postprandial hour and 73.2±4.2% during the total postcibal period, whereas only 24±3% was absorbed during the same time in the duodenum. Thus alcohol ingested with a meal is mainly and rapidly absorbed in the stomach; the contribution of the small intestine below the angle of Treitz to alcohol absorption is negligible.