Experimental transmission of human subacute spongiform encephalopathy to small rodents
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- Tateishi, J., Sato, Y., Nagara, H. et al. Acta Neuropathol (1984) 64: 85. doi:10.1007/BF00695613
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Spongiform encephalopathy was transmitted to mice from a patient belonging to the “Sch” family with Gerstmann-Sträussler-Scheinker's disease (GSS). Incubation periods in the first passage were much shorter than those in mice infected with Creutzfeldt-Jakob disease. Clinical and pathologic findings of mice infected with both disease were almost identical. This is the first successful transmission from a typical GSS case without severe spongiform change which suggests the possible transmissible nature of this disorder.