Summary
Seven cases of diabetic amyotrophy were investigated by histochemistry and electron microscopy of biopsied muscles. Type II fibre atrophy of various grades was observed in the proximal atrophic muscles. Various changes of Z-band were observed in type II atrophic muscle fibres. In addition, mitochondrial changes, accumulation of glycogen, thickening of the capillary basement membrane and changes in the intramuscular nerves were also observed, both in the proximal and distal muscles. Some impaired motoneuron innervation of proximal muscles as well as distal muscles in a poorly controlled diabetic condition is suspected in “diabetic amyotrophy”.
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This paper was read on the 13th Congress of Neuropathology in Gifu, Japan in 1972.
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Tomonaga, M., Tanabe, H., Nozawa, T. et al. Electron microscopic study of the muscle changes in diabetic amyotrophy. Acta Neuropathol 24, 331–339 (1973). https://doi.org/10.1007/BF00685588
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DOI: https://doi.org/10.1007/BF00685588