Abstract
Nefopam is a non-opioid analgesic reported to have some stimulant properties. The subjective, behavioral and physiological effects of nefopam, morphine and d-amphetamine were compared in seven non-dependent substance abusers to assess the abuse potential of nefopam. Morphine and d-amphetamine had significant effects on a number of measures generally consistent with the effects of drugs of the opioid and psychomotor stimulant drug classes. Subjects correctly discriminated between morphine and d-amphetamine. Nefopam was most frequently identified by subjects as being amphetamine-like, though several measures indicated that nefopam produced some sedation. Little or no “liking” of the effects of nefopam was reported by subjects. Overall, nefopam was one fifth as potent as morphine and one quarter as potent as d-amphetamine in producing subjective and physiological effects. The results indicate that nefopam is neither entirely morphine-like nor d-amphetamine-like. In our opinion, nefopam has a lesser potential to be abused than morphine or d-amphetamine.
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References
Bassett JR, Cairncross KD, Hacket NB, Story M (1969) Studies on the peripheral pharmacology of fenazoxine, a potential antidepressant drug. Br J Pharmacol 37:69–78
Beaver WT, Feise GA (1977) A comparison of the analgesic effect of intramuscular nefopam and morphine in patients with postoperative pain. J Clin Pharmacol 17:579–591
Belleville JP, Dorey F, Bellville JW (1979) Effects of nefopam on visual tracking. Clin Pharmacol Ther 26:457–463
Bhatt AM, Pleuvry BJ, Maddison SE (1981) Respiratory and metabolic effects of oral nefopam in human volunteers. Br J Clin Pharmacol 11:209–211
Bloomfield SS, Barden TP, Mitchell J (1980) Nefopam and propoxyphene in episiotomy pain. Clin Pharmacol Ther 27:502–507
Campos VM, Solis EL (1980) The analgesic and hypothermic effects of nefopam, morphine, aspirin, diphenhydramine, and placebo. J Clin Pharmacol 20:42–49
Cole JO, Pope HG, LaBrie R, Ionescu-Pioggia M (1978) Assessing the subjective effects of stimulants in casual users. A methodology and preliminary results. Clin Pharmacol Ther 24:243–252
Conway AC, Mitchell CL (1977) Analgesic studies with nefopam hydrochloride. Arch Int Pharmacodyn Ther 226:156–171
Finney DK (1964) Statistical method in biological assay, Ed. 2. Hofner, New York
Frey LG, Winter JC (1979) Comparison of the discriminative stimulus properties of nefopam and morphine. Psychopharmacology 61:231–232
Gassel MM, Diamantopoulos E, Petropoulos V, Hughes ACR, Ballesteros MLF, Re ON (1976) Controlled clinical trial of oral and parenteral nefopam hydrochloride. A novel and potent analgesic drug. J Clin Pharmacol 16:34–42
Jasinski DR (1977) Assessment of the abuse potential of morphine-like drugs (methods used in man). In: Martin WR (ed) Handbook of experimental pharmacology, vol 45/1. Springer, Berlin Heidelberg New York, pp 197–258
Jasinski DR, Nutt JG, Griffith JD (1974) Effects of diethylpropion and d-amphetamine after subcutaneous and oral administration. Clin Pharmacol Ther 16, 645–652
Klohs MW, Draper MD, Petracek FJ, Ginzel KH, Re ON (1972) Benzoxocines: a new chemical class of centrally acting skeletal muscle relaxants. Drug Research 22:132–133
Klotz AL (1974) Long-term safety of nefopam hydrochloride (Acupan), a new analgesic formulation. Curr Ther Res 16:602–608
Piercey MF, Schroeder LA (1981) Spinal and supraspinal sites for morphine and nefopam analgesia in the mouse. Eur J Pharmacol 74:135–140
Sunshine A, Laska E (1975) Nefopam and morphine in man. Clin Pharmacol Ther 18:530–534
Tobin WE, Gold RH (1972) Nefopam hydrochloride: a novel muscle relaxant. J Clin Pharmacol 12:230–238
Tresnak-Rustad NJ, Wood ME (1981) In vitro biochemical effects of nefopam hydrochloride, a new analgesic agent. Biochem Pharmacol 30:2847–2850
Vonvoightlander PF, Lewis RA, Neff GL, Triezenberg HJ (1983) Involvement of biogenic amines with the mechanisms of novel analgesics. Prog Neuropsychopharmacol Biol Psychiatry 7:651–656
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Jasinski, D.R., Preston, K.L. A comparative assay of nefopam, morphine and d-amphetamine. Psychopharmacology 91, 273–278 (1987). https://doi.org/10.1007/BF00518176
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DOI: https://doi.org/10.1007/BF00518176