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Analysis of the carcinogen 4,4′-methylenedianiline (MDA) in gamma-ray and in autoclave-sterilized polyurethane

Analyse des Carcinogens 4,4′-Methylendianilin (MDA) in Β-Strahlen- und Autoklav-sterilisiertem Polyurethan

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  • Drugs and Toxic Substances
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Summary

A carcinogen, 4,4′-methylenedianiline (MDA, p,p′-diaminodiphenylmethane), was determined in gammaray- and in autoclave-sterilized thermoplastic polyurethane (PU). The determination of MDA in aqueous extracts of PU has been reported, however recovery of MDA and its determination using a complete dissolution of PU by organic solvents have not. In addition, we report the MDA determination in methanol extract of PU. No MDA was detected in gamma-ray sterilized thermoplastic PU, but in autoclavesterilized thermoplastic PU, MDA was detected (possibly formed by hydrolysis). The amount of MDA formed was inversely related to the molecular weight of PU by a second order equation. No change in the weight average molecular weight was observed as a result of autoclave sterilization. Essentially the same amounts of MDA were extracted from PU with serum as with methanol.

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Authors and Affiliations

  1. Department of Medical Devices, National Institute of Hygienic Sciences, 1-18-1, Kamiyoga, Setagaya, 158, Tokyo, Japan

    Hideharu Shintani & Akitada Nakamura

Authors
  1. Hideharu Shintani
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  2. Akitada Nakamura
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Shintani, H., Nakamura, A. Analysis of the carcinogen 4,4′-methylenedianiline (MDA) in gamma-ray and in autoclave-sterilized polyurethane. Z. Anal. Chem. 333, 637–640 (1989). https://doi.org/10.1007/BF00496937

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  • DOI: https://doi.org/10.1007/BF00496937

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