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Nicotine: farmacologische en toxicologische aspecten

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Verslaving

Dat roken een belangrijke risicofactor is voor morbiditeit en mortaliteit kan als bekend worden verondersteld. Toch rookt ongeveer een kwart van de volwassen Nederlanders, want roken is een zeer verslavende gewoonte. Dat hoge verslavingspotentieel kan voor een substantieel deel worden toegeschreven aan de stof nicotine. Nicotine is niet de enige stof in tabak: in tabaksrook zijn zo’n vierduizend chemische verbindingen geïdentificeerd, waaronder vele stoffen met giftige en carcinogene werking.

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Literatuur

  • Benowitz, N.L. & Gourlay S.G. (1997). Cardiovascular toxicity of nicotine: implications for nicotine replacement therapy. Journal of the American College of Cardiology, 29, 1422–1431.

    Article  PubMed  CAS  Google Scholar 

  • Benowitz, N.L. (2003). Cigarette smoking and cardiovascular disease: pathophysiology and implications for treatment. Progress in Cardiovascular Diseases, 46, 91–111.

    Article  PubMed  CAS  Google Scholar 

  • Benowitz, N.L. (2009). Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics. Annual Reviews in Pharmacology and Toxicology, 49, 57–71.

    Article  CAS  Google Scholar 

  • Benowitz, N.L. (2010). Nicotine addiction. New England Journal of Medicine, 362, 2295–2303.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Cohen, G., Roux, J.C., Grailhe, R., Malcolm, G., Changeux, J.P. & Lagercrantz, H. (2005). Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function. Proceedings of the National Acadademy of Science USA, 102, 3817–3821.

    Google Scholar 

  • Cooke, J.P. & Bitterman, H. (2004). Nicotine and angiogenesis: a new paradigm for tobacco-related diseases. Annals of Medicine, 36, 33–40.

    Article  PubMed  CAS  Google Scholar 

  • Eliasson, B. (2003). Cigarette smoking and diabetes. Progress in Cardiovascular Disease, 45, 405–413.

    Article  CAS  Google Scholar 

  • Foulds, J., Stapleton, J., Swettenham, J., Bell, N., McSorley, K. & Russell, M.A. (1996). Cognitive performance effects of subcutaneous nicotine in smokers and never-smokers. Psychopharmacology (Berl), 127, 31–38.

    Article  CAS  Google Scholar 

  • Foulds, J., Stapleton, J.A., Bell, N., Swettenham, J., Jarvis, M.J. & Russell, M.A. (1997). Mood and physiological effects of subcutaneous nicotine in smokers and never-smokers. Drug and Alcohol Dependence, 14, 105–115.

    Article  Google Scholar 

  • Harvey, D.M., Yasar, S., Heishman, S.J., Panlilio, L.V., Henningfield, J.E. & Goldberg, S.R. (2004). Nicotine serves as an effective reinforcer of intravenous drug-taking behavior in human cigarette smokers. Psychopharmacology (Berl), 175, 134–142.

    Article  CAS  Google Scholar 

  • Hecht, S.S. (1999). Tobacco smoke carcinogens and lung cancer. Journal of the National Cancer Institute, 21, 1194–1210.

    Article  Google Scholar 

  • Henley, S.J., Connell, C.J., Richter, P., Husten, C., Pechacek, T., e.a. 2007. Tobacco-related disease mortality among men who switched from cigarettes to spit tobacco. Tobacco Control, 16, 22–28.

    Article  PubMed Central  PubMed  Google Scholar 

  • Hoffmann, D. & Hoffmann, I. (1997). The changing cigarette, 1950-1995. Journal of Toxicology and Environmental Health, 50, 307–364.

    Article  PubMed  CAS  Google Scholar 

  • Joseph, A.M., Norman, S.M., Ferry, L.H., Prochazka, A.V., Westman, E.C., e.a. (1996). The safety of transdermal nicotine as an aid to smoking cessation in patients with cardiac disease. New England Journal of Medicine, 335, 1792–1798.

    Article  PubMed  CAS  Google Scholar 

  • Kalman, D. (2002). The subjective effects of nicotine: methodological issues, a review of experimental studies, and recommendations for future research. Nicotine and Tobacco Research, 4, 25–70.

    Article  PubMed  CAS  Google Scholar 

  • Luo, J., Ye, W., Zendehdel, K., Adami, J., Adami, H.O., e.a. (2007). Oral use of Swedish moist snuff (snus) and risk for cancer of the mouth, lung, and pancreas in male construction workers: a retrospective cohort study. Lancet, 369, 2015–2020.

    Article  PubMed  Google Scholar 

  • Malizia, E., Andreucci, G., Alfani, F., Smeriglio, M. & Nicholai, P. (1983). Acute intoxication with nicotine alkaloids and cannabinoids in children from ingestion of cigarettes. Human Toxicology, 2, 315–316.

    Article  PubMed  CAS  Google Scholar 

  • Mayer, B. (2014). How much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century. Archives in Toxicology, 88, 5–7.

    Article  CAS  Google Scholar 

  • Murray, R.P., Bailey, W.C., Daniels, K., Bjornson, W.M., Kurnow, K., Connett, J.E., Nides, M.A. & Kiley, J.P. (1996). Safety of nicotine polacrilex gum used by 3,094 participants in the Lung Health Study. Lung Health Study Research Group. Chest, 109, 438–445.

    Article  PubMed  CAS  Google Scholar 

  • National Institute for Occupational Safetv and Health (2000). Registry of toxic effects of chemical substances, NIOSH, Cincinnati. (CD-ROM version.) Denver: Micromedex.

  • Pidoplichko, V.I., DeBiasi, M., Williams, J.T. & Dani, J.A. (1997). Nicotine activates and desensitizes midbrain dopamine neurons. Nature, 27, 401–404.

    Google Scholar 

  • Puranik, R. & Celermajer, D.S. (2003). Smoking and endothelial function. Progress in Cardiovascular Disease, 45, 443–458.

    Article  CAS  Google Scholar 

  • Sherwood, N. (1993). Effects of nicotine on human performance. Human Psychopharmacology, 8, 155–184.

    Article  CAS  Google Scholar 

  • Spindel, E.R. (2009). Is nicotine the estrogen of lung cancer? American Journal of Respiratory Critical Care Medicine, 15, 1081–1082.

    Article  Google Scholar 

  • Tyndale, R.F. & Sellers, E.M. (2002). Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior. Therapeutic Drug Monitoring, 24, 163–171.

    Article  PubMed  CAS  Google Scholar 

  • Vleeming, W., Schenk, E. & Opperhuizen, A. (2005). Van tabakszaad naar tabaksrook. In K. Knol, C. Hilvering, D.J.Th. Wagener & M.C. Willemsen (red.), Tabaksgebruik: gevolgen en bestrijding (pp. 27–41). Utrecht: Lemma.

  • Warren, G.W. & Singh, A.K. (2013). Nicotine and lung cancer. Journal of Carcinogenesis, 31, 1.

    Article  CAS  Google Scholar 

  • Wennberg, P., Eliasson, M., Hallmans, G., Johansson, L., Boman, K. & Jansson, J.H. (2007). The risk of myocardial infarction and sudden cardiac death amongst snuff users with or without a previous history of smoking. Journal of Internal Medicine, 262, 360–367.

    Article  PubMed  CAS  Google Scholar 

  • Zeidler, R., Albermann, K. & Lang, S. (2007). Nicotine and apoptosis. Apoptosis, 12, 1927–1943.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. faculteit Management, Science en Technologie, Open Universiteit, Utrecht, The Netherlands

    Raymond Niesink

  2. Nationaal Expertisecentrum Tabaksontmoediging, Trimbosinstituut, Utrecht, The Netherlands

    Esther Croes

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  1. Raymond Niesink
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  2. Esther Croes
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Correspondence to Raymond Niesink.

Additional information

Dr. R.J.M. Niesink is farmacoloog/toxicoloog en universitair hoofddocent bij de faculteit Management, Science en Technologie van de Open Universiteit. Hij is senior wetenschappelijk medewerker bij het Programma Drug Monitoring van het Trimbos-instituut en landelijk coördinator van het Drugs Informatie en Monitoring Systeem. E-mail: rniesink@trimbos.nl.Dr. E.A. Croes MD arts-epidemioloog, is senior wetenschappelijk medewerker bij het Nationaal Expertisecentrum Tabaksontmoediging van het Trimbosinstituut.

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Niesink, R., Croes, E. Nicotine: farmacologische en toxicologische aspecten. VERSLAVING 10, 55–67 (2014). https://doi.org/10.1007/s12501-014-0007-5

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