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SPECT myocardial perfusion imaging for the assessment of left ventricular mechanical dyssynchrony

  • Major Achievements in Nuclear Cardiology
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Journal of Nuclear Cardiology Aims and scope

Abstract

Phase analysis of gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is an evolving technique for measuring LV mechanical dyssynchrony. Since its inception in 2005, it has undergone considerable technical development and clinical evaluation. This article reviews the background, the technical and clinical characteristics, and evolving clinical applications of phase analysis of gated SPECT MPI in patients requiring cardiac resynchronization therapy or implantable cardioverter defibrillator therapy and in assessing LV diastolic dyssynchrony.

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Acknowledgments

The authors thank Dr Maureen M. Henneman, Dr Mark J. Boogers, and colleagues at Leiden University Medical Center, Leiden, The Netherlands; Dr Wael AlJaroudi and colleagues at University of Alabama at Birmingham, Birmingham, AL and Cleveland Clinic, Cleveland, OH; Dr Mark A. Trimble and colleagues at Duke University Medical Center, Durham, NC; Dr Matti Friehling and colleagues at University of Pittsburgh Medical Center, Pittsburgh, PA; Dr Javed Butler and colleagues at Emory University, Atlanta, GA; Dr Dianfu Li and colleagues at Nanjing Medical University, Nanjing, Jiangsu, China; Dr Xianhe Lin and colleagues at Anhui Medical University, Hefei, Anhui, China; Dr Kenneth J. Nichols and colleagues at St. Francis Hospital, Roslyn, NA; Dr Jose C. Meneghetti and colleagues at University of Sao Paulo, Sao Paulo, Brazil; Dr Philipp A. Kaufmann and colleagues at University Hospital Zurich, Zurich, Switzerland; and many others, who have contributed to the area of assessment of LV mechanical dyssynchrony by phase analysis of SPECT MPI. Ji Chen and Ernest V. Garcia receive royalties from the sale of the Emory Cardiac Toolbox with SyncTool. The terms of this arrangement have been reviewed and approved by Emory University in accordance with its conflict-of-interest practice.

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Authors and Affiliations

  1. Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA, 30322, USA

    Ji Chen PhD & Ernest V. Garcia PhD

  2. Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands

    Jeroen J. Bax MD

  3. Division of Cardiology, University of Alabama at Birmingham, Birmingham, AL, USA

    Ami E. Iskandrian MD

  4. Department of Radiology, Duke University Medical Center, Durham, NC, USA

    Salvador Borges-Neto MD

  5. Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Prem Soman MD, PhD

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  1. Ji Chen PhD
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  2. Ernest V. Garcia PhD
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  3. Jeroen J. Bax MD
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  4. Ami E. Iskandrian MD
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  5. Salvador Borges-Neto MD
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  6. Prem Soman MD, PhD
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Corresponding author

Correspondence to Ji Chen PhD.

Additional information

The research in phase analysis is supported in part by a NIH/NHLBI Grant (1R01HL094438, PI: Ji Chen, PhD)

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Chen, J., Garcia, E.V., Bax, J.J. et al. SPECT myocardial perfusion imaging for the assessment of left ventricular mechanical dyssynchrony. J. Nucl. Cardiol. 18, 685–694 (2011). https://doi.org/10.1007/s12350-011-9392-x

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