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Analytical description of IMS-signals

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International Journal for Ion Mobility Spectrometry

Abstract

Ion mobility spectrometry (IMS) is widely used to detect chemical warfare agents, illegal drugs or explosives. In such cases often the occurrence of single, well known analytes or rather small groups of analytes is considered. To retrieve analytes in rather complex matrices like human breath it becomes essential to describe all analytes, known and unknown. Therefore, a mathematical description of the peak shape of well known analytes–including their concentration profiles–and the shapes of unknown or overlapping peaks by a minimum number of parameters could significantly improve the recognition and quantification of signals in IMS-chromatograms. In the following, a function is presented which describes the theoretical surface of a peak on a given position and height. In addition, the peak-function method can be applied for decomposition of overlapping signals within IMS-chromatograms, which furthermore enables a direct determination of the volume of each peak for an accurate quantification.

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Acknowledgements

The financial support of the Bundesministerium für Bildung und Forschung and the Ministerium für Innovation, Wissenschaft, Forschung und Technologie des Landes Nordrhein-Westfalen is gratefully acknowledged. The work was funded partly by the projects BAMOD (Breath-gas analysis for molecular-oriented detection of minimal diseases–LSHC-CT-2005-019031) and SGL for USaR (Second Generation Locator for Urban Search and Rescue Operations – FP7-SEC-2007-1 Project 217967) of the European Union and the high-tech strategy funds of the Federal Republic of Germany (project Metabolit – 01SF0716).

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  1. Department of Metabolomics, ISAS-Institute for Analytical Sciences, Bunsen-Kirchhoff-Straße 11, 44139, Dortmund, Germany

    Bertram Bödeker & Jörg Ingo Baumbach

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  1. Bertram Bödeker
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  2. Jörg Ingo Baumbach
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Correspondence to Bertram Bödeker.

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Bödeker, B., Baumbach, J.I. Analytical description of IMS-signals. Int. J. Ion Mobil. Spec. 12, 103–108 (2009). https://doi.org/10.1007/s12127-009-0024-y

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