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Atomic layer deposition of TiO2 thin films on nanoporous alumina templates: Medical applications

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Abstract

Nanostructured materials may play a significant role in controlled release of pharmacologic agents for treatment of cancer. Many nanoporous polymer materials are inadequate for use in drug delivery. Nanoporous alumina provides several advantages over other materials for use in controlled drug delivery and other medical applications. Atomic layer deposition was used to coat all the surfaces of a nanoporous alumina membrane in order to reduce the pore size in a controlled manner. Neither the 20 nm nor the 100 nm TiO2-coated nanoporous alumina membranes exhibited statistically lower viability compared to the uncoated nanoporous alumina membrane control materials. Nanostructured materials prepared using atomic layer deposition may be useful for delivering a pharmacologic agent at a precise rate to a specific location in the body. These materials may serve as the basis for “smart” drug delivery devices, orthopedic implants, or self-sterilizing medical devices.

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Authors and Affiliations

  1. Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, 2147 Burlington Engineering Labs, Raleigh, NC, 27695-7115, USA

    Roger J. Narayan & Nancy A. Monteiro-Riviere

  2. Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, USA

    Nancy A. Monteiro-Riviere

  3. Savannah River National Laboratory, Aiken, SC, USA

    Robin L. Brigmon

  4. Materials Science Division, Argonne National Laboratory, Argonne, IL, 60439, USA

    Michael J. Pellin

  5. Energy Systems Division, Argonne National Laboratory, Argonne, IL, 60439, USA

    Jeffrey W. Elam

Authors
  1. Roger J. Narayan
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  2. Nancy A. Monteiro-Riviere
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  3. Robin L. Brigmon
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  4. Michael J. Pellin
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  5. Jeffrey W. Elam
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Correspondence to Roger J. Narayan.

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Narayan, R.J., Monteiro-Riviere, N.A., Brigmon, R.L. et al. Atomic layer deposition of TiO2 thin films on nanoporous alumina templates: Medical applications. JOM 61, 12–16 (2009). https://doi.org/10.1007/s11837-009-0081-z

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  • DOI: https://doi.org/10.1007/s11837-009-0081-z

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