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Effects of Laparoscopic Gastric Band Applications on Plasma and Fundic Acylated Ghrelin Levels in Morbidly Obese Patients

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Abstract

Background

It has been proposed that laparoscopic adjustable gastric banding (LAGB) procedure might play a role in modulation of fundic ghrelin production. To test this hypothesis, we examined plasma and tissue concentrations of acylated ghrelin in morbidly obese patients before and 6 months after LAGB. Baseline levels of acylated ghrelin in morbidly obese patients were also compared with those in age-matched, healthy, non-obese controls.

Methods

We studied 21 patients who had been operated on for morbid obesity (M/F = 9/12, BMI = 49.3 ± 5.3 kg/m2) and 16 healthy, non-obese persons (M/F = 7/9, BMI = 23.0 ± 1.7 kg/m2). Fasting blood samples were collected once from the non-obese controls as well as the morbidly obese patients before and 6 months after the LAGB. The morbidly obese patients and their respective controls underwent gastroscopy for fundic biopsy. The plasma and fundic acylated ghrelin levels were evaluated in these groups by enzyme-linked immunosorbent assay.

Results

The plasma and fundic acylated ghrelin concentrations were significantly lower in obese patients than in non-obese controls (2.8 ± 1.0 ng/ml, 727 ± 171.7 ng/g tissue, respectively; p = 0.000). These parameters were significantly increased in morbidly obese patients 6 months after LAGB (4.1 ± 1.2 ng/ml and p = 0.001; 999 ± 292.1 ng/g tissue and p = 0.003, respectively).

Conclusions

We showed that fundic production of acylated ghrelin was significantly increased in morbidly obese patients 6 months after LAGB. Moreover, the weight loss after LAGB occurred in spite of the significant increase in the plasma and fundic acylated ghrelin levels. The potential role of ghrelin as being responsible for the weight loss after bariatric surgery needs to be elucidated in further studies.

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Acknowledgment

This work was supported by The Research Fund of Istanbul University (Project Number BYP-871/23122005).

Conflict of interest

The authors declare that they have no conflict of interest related to the publication of this article.

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Authors and Affiliations

  1. Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, 34303, Cerrahpasa, Istanbul, Turkey

    Remise Gelisgen, Hayriye Erman & Hafize Uzun

  2. Department of Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey

    Kagan Zengin, Ahmet Kocael, Pınar Kocael & Mustafa Taskın

  3. Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey

    Birol Baysal

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  1. Remise Gelisgen
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Correspondence to Remise Gelisgen.

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Gelisgen, R., Zengin, K., Kocael, A. et al. Effects of Laparoscopic Gastric Band Applications on Plasma and Fundic Acylated Ghrelin Levels in Morbidly Obese Patients. OBES SURG 22, 299–305 (2012). https://doi.org/10.1007/s11695-011-0498-7

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  • DOI: https://doi.org/10.1007/s11695-011-0498-7

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