Skip to main content

Advertisement

SpringerLink
Log in

Association of 10q23 with colorectal cancer in a Chinese population

  • Published:
Molecular Biology Reports Aims and scope Submit manuscript

Abstract

Recently, a genome-wide association study of gastric cancer (GC) reported the significant association of seven genetic variants (rs4072037 and rs4460629 on 1q22; rs753724, rs11187842, rs3765524, rs2274223, and rs3781264 on 10q23) with GC in a Chinese population. These findings were confirmed in a subsequent independent study. However, it remains unknown whether these loci are associated with an increased risk of colorectal cancer (CRC). This study was to test whether the seven single nucleotide polymorphisms (SNPs) associated with GC were also associated with CRC in a Chinese population. The seven SNPs were genotyped using MassARRAY system. Allelic, genotypic, and haplotypic associations of the SNPs with CRC were investigated using χ2 tests and logistic regression analysis. The SNPs rs3765524 and rs2274223, located on 10q23, were found to have significant protective effects against CRC, with equal odds ratios per allele. The two SNPs located on 1q22 (rs4072037 and rs4460629) showed a weak association with CRC. No significant association was identified with CRC for the remaining three SNPs located on 10q23 (rs753724, rs11187842, and rs3781264). These results suggest that rs3765524 and rs2274223 on 10q23 are associated with a protective effect against CRC in a Chinese population.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Boyle P, Levin B (2008) International agency for research on cancer. World cancer report. IARC Press, Lyon

    Google Scholar 

  2. Yang L, Parkin DM, Ferlay J, Li L, Chen Y (2005) Estimates of cancer incidence in China for 2000 and projections for. Cancer Epidemiol Biomarkers Prev 14(1):243–250

    PubMed  Google Scholar 

  3. Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K (2000) Environmental and heritable factors in the causation of cancer–analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 343(2):78–85

    Article  PubMed  CAS  Google Scholar 

  4. Bost B, de Vienne D, Hospital F, Moreau L, Dillmann C (2001) Genetic and nongenetic bases for the L-shaped distribution of quantitative trait loci effects. Genetics 157(4):1773–1787

    PubMed  CAS  Google Scholar 

  5. Hosking FJ, Dobbins SE, Houlston RS (2011) Genome-wide association studies for detecting cancer susceptibility. Br Med Bull 97:27–46

    Article  PubMed  Google Scholar 

  6. Houlston RS, Cheadle J, Dobbins SE et al (2010) Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33. Nat Genet 42(11):973–977

    Article  PubMed  CAS  Google Scholar 

  7. Tomlinson IP, Webb E, Carvajal-Carmona L et al (2008) A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat Genet 40(5):623–630

    Article  PubMed  CAS  Google Scholar 

  8. Tomlinson I, Webb E, Carvajal-Carmona L et al (2007) A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet 39(8):984–988

    Article  PubMed  CAS  Google Scholar 

  9. Zanke BW, Greenwood CM, Rangrej J et al (2007) Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet 39(8):989–994

    Article  PubMed  CAS  Google Scholar 

  10. Tenesa A, Farrington SM, Prendergast JG et al (2008) Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet 40(5):631–637

    Article  PubMed  CAS  Google Scholar 

  11. Tomlinson IP, Carvajal-Carmona LG, Dobbins SE et al (2011) Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4 and BMP2 explain part of the missing heritability of colorectal cancer. PLoS Genet 7(6):e1002105

    Article  PubMed  CAS  Google Scholar 

  12. Houlston RS, Webb E, Broderick P et al (2008) Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet 40(12):1426–1435

    Article  PubMed  CAS  Google Scholar 

  13. Xiong F, Wu C, Bi X et al (2010) Risk of genome-wide association study-identified genetic variants for colorectal cancer in a Chinese population. Cancer Epidemiol Biomarkers Prev 19(7):1855–1861

    Article  PubMed  CAS  Google Scholar 

  14. Ho JW, Choi SC, Lee YF et al (2011) Replication study of SNP associations for colorectal cancer in Hong Kong Chinese. Br J Cancer 104(2):369–375

    Article  PubMed  CAS  Google Scholar 

  15. Abnet CC, Freedman ND, Hu N et al (2010) A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Nat Genet 42(9):764–767

    Article  PubMed  CAS  Google Scholar 

  16. Zhang H, Jin G, Li H, Ren C, Ding Y, Zhang Q, Deng B, Wang J, Hu Z, Xu Y, Shen H (2011) Genetic variants at 1q22 and 10q23 reproducibly associated with gastric cancer susceptibility in a Chinese population. Carcinogenesis 32(6):848–852

    Article  PubMed  CAS  Google Scholar 

  17. Li X, Yang XX, Hu NY, Sun JZ, Li FX, Li M (2011) A risk-associated single nucleotide polymorphism of SMAD7 is common to colorectal, gastric, and lung cancers in a Han Chinese population. Mol Biol Rep 38(8):5093–5097

    Article  PubMed  CAS  Google Scholar 

  18. Wang LD, Zhou FY, Li XM et al (2010) Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet 42(9):759–763

    Article  PubMed  CAS  Google Scholar 

  19. Fukami K (2002) Structure, regulation, and function of phospholipase C isozymes. J Biochem 131(3):293–299

    Article  PubMed  CAS  Google Scholar 

  20. Rhee SG (2001) Regulation of phosphoinositide-specific phospholipase C. Annu Rev Biochem 70:281–312

    Article  PubMed  CAS  Google Scholar 

  21. Huang CL (2007) Complex roles of PIP2 in the regulation of ion channels and transporters. Am J Physiol Renal Physiol 293(6):F1761–F1765

    Article  PubMed  CAS  Google Scholar 

  22. Hilgemann DW, Feng S, Nasuhoglu C (2001) The complex and intriguing lives of PIP2 with ion channels and transporters. Sci STKE 2001(111):re19

    Article  PubMed  CAS  Google Scholar 

  23. Jin TG, Satoh T, Liao Y et al (2001) Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling. J Biol Chem 276(32):30301–30307

    Article  PubMed  CAS  Google Scholar 

  24. Lopez I, Mak EC, Ding J, Hamm HE, Lomasney JW (2001) A novel bifunctional phospholipase c that is regulated by G alpha 12 and stimulates the Ras/mitogen activated protein kinase pathway. J Biol Chem 276(4):2758–2765

    Article  PubMed  CAS  Google Scholar 

  25. Wing MR, Bourdon DM, Harden TK (2003) PLC-epsilon: a shared effector protein in Ras-, Rho-, and G alpha beta gamma-mediated signaling. Mol Interv 3(5):273–280

    Article  PubMed  CAS  Google Scholar 

  26. Ou L, Guo Y, Luo C, Wu X, Zhao Y, Cai X (2010) RNA interference suppressing PLCE1 gene expression decreases invasive power of human bladder cancer T24 cell line. Cancer Genet Cytogenet 200(2):110–119

    Article  PubMed  CAS  Google Scholar 

  27. Wang X, Zhou C, Qiu G, Yang Y, Yan D, Xing T, Fan J, Tang H, Peng Z (2012) Phospholipase C epsilon plays a suppressive role in incidence of colorectal cancer. Med Oncol 29(2):1051–1058

    Google Scholar 

  28. Johmura Y, Osada S, Nishizuka M, Imagawa M (2008) FAD24, a regulator of adipogenesis, is required for the regulation of DNA replication in cell proliferation. Biol Pharm Bull 31(6):1092–1095

    Article  PubMed  CAS  Google Scholar 

  29. Taylor-Papadimitriou J, Burchell JM, Plunkett T, Graham R, Correa I, Miles D, Smith M (2002) MUC1 and the immunobiology of cancer. J Mammary Gland Biol Neoplasia 7(2):209–221

    Article  PubMed  Google Scholar 

  30. Ng W, Loh AX, Teixeira AS, Pereira SP, Swallow DM (2008) Genetic regulation of MUC1 alternative splicing in human tissues. Br J Cancer 99(6):978–985

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This work was supported by Key Programs for Science and Technology Development of Guangzhou (Grant No. 2008A1-E4151).

Author information

Authors and Affiliations

  1. School of Biotechnology, Southern Medical University, Guangzhou, 510515, China

    Fen-Xia Li, Xue-Xi Yang, Ying-Song Wu & Ming Li

  2. The First Clinical College, Southern Medical University, Guangzhou, 510515, China

    Xuan-Qiu He

  3. Department of Clinical, First Affiliated Hospital of Nanchang University, Nanchang, 330006, China

    Ni-Ya Hu

Authors
  1. Fen-Xia Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xue-Xi Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xuan-Qiu He
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ni-Ya Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ying-Song Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ming Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ming Li.

Additional information

Fen-Xia Li and Xue-Xi Yang contributed equally to this work.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOC 32 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Li, FX., Yang, XX., He, XQ. et al. Association of 10q23 with colorectal cancer in a Chinese population. Mol Biol Rep 39, 9557–9562 (2012). https://doi.org/10.1007/s11033-012-1820-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11033-012-1820-8

Keywords

Search

Navigation