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Mitochondrial Carrier Homolog 2: A Clue to Cracking the BCL-2 Family Riddle?

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Abstract

BCL-2 family members are pivotal regulators of the apoptotic process. Mitochondria are a major site-of-action for these proteins. Several prominent alterations occur to mitochondria during apoptosis that seem to be part of the “mitochondrial apoptotic program.” The BCL-2 family members are believed to be the major regulators of this program, however their exact mechanism of action still remains a mystery. BID, a pro-apoptotic BCL-2 family member plays an essential role in initiating this program. Recently, we have revealed that in apoptotic cells the activated/truncated form of BID, tBID, interacts with a novel, uncharacterized protein named mitochondrial carrier homolog 2 (Mtch2). Mtch2 is a conserved protein that is similar to members of the mitochondrial carrier protein (MCP) family. This review summarizes the current knowledge regarding BCL-2 family members and the mitochondrial apoptotic program and examines the possible involvement of Mtch2 in this program.

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References

  • Basanez, G., Sharpe, J. C., Galanis, J., Brandt, T. B., Hardwick, J. M., and Zimmerberg, J. (2002). J. Biol. Chem. 277, 49360–49365.

    Article  PubMed  Google Scholar 

  • Bernardi, P., and Azzone, G. F. (1981). J. Biol. Chem. 256, 7187–7192.

    PubMed  Google Scholar 

  • Bernardi, P., Petronilli, V., Di Lisa, F., and Forte, M. (2001). Trends Biochem. Sci. 26, 112–117.

    Article  PubMed  Google Scholar 

  • Cory, S., and Adams, J. M. (2002). Nat. Rev. Cancer 2, 647–656.

    Article  PubMed  Google Scholar 

  • Danial, N. N., Gramm, C. F., Scorrano, L., Zhang, C. Y., Krauss, S., Ranger, A. M., Datta, S. R., Greenberg, M. E., Licklider, L. J., Lowell, B. B., Gygi, S. P., and Korsmeyer, S. J. (2003). Nature 424, 952–956.

    Google Scholar 

  • Danial, N. N., and Korsmeyer, S. J. (2004). Cell 116, 205–219.

    PubMed  Google Scholar 

  • Degli Esposti, M., Ferry, G., Masdehors, P., Boutin, J. A., Hickman, J. A., and Dive, C. (2003). J. Biol. Chem. 278, 15749–15757.

    Article  PubMed  Google Scholar 

  • Dejean, L. M., Martinez-Caballero, S., Guo, L., Hughes, C., Teijido, O., Ducret, T., Ichas, F., Korsmeyer, S. J., Antonsson, B., Jonas, E. A., and Kinnally, K. W. (2005). Mol. Biol. Cell. 16, 2424–2432.

    Article  PubMed  Google Scholar 

  • Desagher, S., Osen-Sand, A., Montessuit, S., Magnenat, E., Vilbois, F., Hochmann, A., Journot, L., Antonsson, B., and Martinou, J. C. (2001). Mol. Cell 8, 601–611.

    Article  PubMed  Google Scholar 

  • Desagher, S., Osen-Sand, A., Nichols, A., Eskes, R., Montessuit, S., Lauper, S., Maundrell, K., Antonsson, B., and Martinou, J. C. (1999). J. Cell Biol. 144, 891–901.

    Article  PubMed  Google Scholar 

  • Eskes, R., Desagher, S., Antonsson, B., and Martinou, J. C. (2000). Mol. Cell Biol. 20, 929–935.

    Article  PubMed  Google Scholar 

  • Frey, T. G., and Mannella, C. A. (2000). Trends Biochem. Sci. 25, 319–324.

    Article  PubMed  Google Scholar 

  • Goldstein, J. C., Waterhouse, N. J., Juin, P., Evan, G. I., and Green, D. R. (2000). Nat. Cell Biol. 2, 156–162.

    Article  PubMed  Google Scholar 

  • Goping, I. S., Gross, A., Lavoie, J. N., Nguyen, M., Jemmerson, R., Roth, K., Korsmeyer, S. J., and Shore, G. C. (1998). J. Cell Biol. 143, 207–215.

    Article  PubMed  Google Scholar 

  • Griffiths, G. J., Dubrez, L., Morgan, C. P., Jones, N. A., Whitehouse, J., Corfe, B. M., Dive, C., and Hickman, J. A. (1999). J. Cell Biol. 144, 903–914.

    Article  PubMed  Google Scholar 

  • Grinberg, M., Sarig, R., Zaltsman, Y., Frumkin, D., Grammatikakis, N., Reuveny, E., and Gross, A. (2002). J. Biol. Chem. 277, 12237–12245.

    Article  PubMed  Google Scholar 

  • Grinberg, M., Schwarz, M., Zaltsman, Y., Eini, T., Niv, H., Pietrokovski, S., and Gross, A. (2005). Mol. Cell. Biol. 25, 4579–4590.

    Article  PubMed  Google Scholar 

  • Gross, A., Jockel, J., Wei, M. C., and Korsmeyer, S. J. (1998). EMBO J 17, 3878–3885.

    Article  PubMed  Google Scholar 

  • Gross, A., Yin, X. M., Wang, K., Wei, M. C., Jockel, J., Milliman, C., Erdjument-Bromage, H., Tempst, P., and Korsmeyer, S. J. (1999). J. Biol. Chem. 274, 1156–1163.

    PubMed  Google Scholar 

  • Harada, H., Quearry, B., Ruiz-Vela, A., and Korsmeyer, S. J. (2004). Proc. Natl. Acad. Sci. USA 101, 15313–15317.

    PubMed  Google Scholar 

  • Huang, D. C., and Strasser, A. (2000). Cell 103, 839–842.

    PubMed  Google Scholar 

  • Jagasia, R., Grote, P., Westermann, B., and Conradt, B. (2005). Nature 433, 754–760.

    PubMed  Google Scholar 

  • Karbowski, M., Lee, Y. J., Gaume, B., Jeong, S. Y., Frank, S., Nechushtan, A., Santel, A., Fuller, M., Smith, C. L., and Youle, R. J. (2002). J. Cell Biol. 159, 931–938.

    Article  PubMed  Google Scholar 

  • Kim, P. K., Annis, M. G., Dlugosz, P. J., Leber, B., and Andrews, D. W. (2004). Mol. Cell 14, 523–529.

    PubMed  Google Scholar 

  • Kuwana, T., Bouchier-Hayes, L., Chipuk, J. E., Bonzon, C., Sullivan, B. A., Green, D. R., and Newmeyer, D. D. (2005). Mol. Cell 17, 525–535.

    Article  PubMed  Google Scholar 

  • Kuwana, T., Mackey, M. R., Perkins, G., Ellisman, M. H., Latterich, M., Schneiter, R., Green, D. R., and Newmeyer, D. D. (2002). Cell 111, 331–342.

    Article  PubMed  Google Scholar 

  • Lei, K., and Davis, R. J. (2003). Proc. Natl. Acad. Sci. USA 100, 2432–2437.

    Article  PubMed  Google Scholar 

  • Letai, A., Bassik, M. C., Walensky, L. D., Sorcinelli, M. D., Weiler, S., and Korsmeyer, S. J. (2002). Cancer Cell 2, 183–192.

    Article  PubMed  Google Scholar 

  • Li, H., Zhu, H., Xu, C. J., and Yuan, J. (1998). Cell 49, 491–501.

    Article  Google Scholar 

  • Luo, X., Budihardjo, I., Zou, H., Slaughter, C., and Wang, X. (1998). Cell 94, 481–490.

    PubMed  Google Scholar 

  • Moreau, C., Cartron, P. F., Hunt, A., Meflah, K., Green, D. R., Evan, G., Vallette, F. M., and Juin, P. (2003). J. Biol. Chem. 278, 19426–19435.

    Article  PubMed  Google Scholar 

  • Muchmore, S. W., Sattler, M., Liang, H., Meadows, R. P., Harlan, J. E., Yoon, H. S., Nettesheim, D., Chang, B. S., Thompson, C. B., Wong, S. L., Ng, S. L., and Fesik, S. W. (1996). Nature 381, 335–341.

    Article  PubMed  Google Scholar 

  • Palmieri, F. (1994). FEBS Lett. 346, 48–54.

    Article  PubMed  Google Scholar 

  • Pavlov, E. V., Priault, M., Pietkiewicz, D., Cheng, E. H., Antonsson, B., Manon, S., Korsmeyer, S. J., Mannella, C. A., and Kinnally, K. W. (2001). J. Cell Biol. 155, 725–731.

    Article  PubMed  Google Scholar 

  • Petros, A. M., Olejniczak, E. T., and Fesik, S. W. (2004). Biochim. Biophys. Acta 1644, 83–94.

    Article  PubMed  Google Scholar 

  • Puthalakath, H., Huang, D. C., O’Reilly, L. A., King, S. M., and Strasser, A. (1999). Mol. Cell 3, 287–296.

    Article  PubMed  Google Scholar 

  • Puthalakath, H., and Strasser, A. (2002). Cell Death Differ. 9, 505–512.

    Article  PubMed  Google Scholar 

  • Saito, M., Korsmeyer, S. J., and Schlesinger, P. H. (2000). Nat. Cell Biol. 2, 553–555.

    Article  PubMed  Google Scholar 

  • Sarig, R., Zaltsman, Y., Marcellus, R. C., Flavell, R., Mak, T. W., and Gross, A. (2003). J. Biol. Chem. 278, 10707–10715.

    Article  PubMed  Google Scholar 

  • Schagger, H. (2001). Methods Cell Biol. 65, 231–244.

    PubMed  Google Scholar 

  • Schendel, S. L., Montal, M., and Reed, J. C. (1998). Cell Death Differ. 5, 372–380.

    Article  PubMed  Google Scholar 

  • Scorrano, L., Ashiya, M., Buttle, K., Weiler, S., Oakes, S. A., Mannella, C. A., and Korsmeyer, S. J. (2002). Dev. Cell 2, 55–67.

    Article  PubMed  Google Scholar 

  • Shi, Y. (2002). Mol. Cell 9, 459–470.

    Article  PubMed  Google Scholar 

  • Shimizu, S., Konishi, A., Kodama, T., and Tsujimoto, Y. (2000). Proc. Natl. Acad. Sci. USA 97, 3100–3105.

    Google Scholar 

  • Shimizu, S., and Tsujimoto, Y. (2000). Proc. Natl. Acad. Sci. U S A 97, 577–582.

    Article  PubMed  Google Scholar 

  • Vander Heiden, M. G., Li, X. X., Gottleib, E., Hill, R. B., Thompson, C. B., and Colombini, M. (2001). J. Biol. Chem. 276, 19414–19419.

    Article  PubMed  Google Scholar 

  • Vander Heiden, M. G., and Thompson, C. B. (1999). Nat. Cell Biol. 1, E209–E216.

    Article  PubMed  Google Scholar 

  • Varfolomeev, E. E., and Ashkenazi, A. (2004). Cell 116, 491–497.

    Article  PubMed  Google Scholar 

  • Walker, J. E., and Runswick, M. J. (1993). J. Bioenerg. Biomembr. 25, 435–446.

    Article  PubMed  Google Scholar 

  • Wang, X. (2001). Genes Dev. 15, 2922–2933.

    PubMed  Google Scholar 

  • Wei, M. C., Lindsten, T., Mootha, V. K., Weiler, S., Gross, A., Ashiya, M., Thompson, C. B., and Korsmeyer, S. J. (2000). Genes Dev. 14, 2060–2071.

    PubMed  Google Scholar 

  • Wei, M. C., Zong, W. X., Cheng, E. H., Lindsten, T., Panoutsakopoulou, V., Ross, A. J., Roth, K. A., MacGregor, G. R., Thompson, C. B., and Korsmeyer, S. J. (2001). Science 292, 727–730.

    Google Scholar 

  • Xu, X., Shi, Y. C., Gao, W., Mao, G., Zhao, G., Agrawal, S., Chisolm, G. M., Sui, D., and Cui, M. Z. (2002). J. Biol. Chem. 277, 48913–48922.

    Article  PubMed  Google Scholar 

  • Yin, X. M., Wang, K., Gross, A., Zhao, Y., Zinkel, S., Klocke, B., Roth, K. A., and Korsmeyer, S. J. (1999). Nature 400, 886–891.

    Google Scholar 

  • Zha, J., Harada, H., Yang, E., Jockel, J., and Korsmeyer, S. J. (1996). Cell 87, 619–628.

    Article  PubMed  Google Scholar 

  • Zhang, Q. H., Ye, M., Wu, X. Y., Ren, S. X., Zhao, M., Zhao, C. J., Fu, G., Shen, Y., Fan, H. Y., Lu, G., Zhong, M., Xu, X. R., Han, Z. G., Zhang, J. W., Tao, J., Huang, Q. H., Zhou, J., Hu, G. X., Gu, J., Chen, S. J., and Chen, Z. (2000). Genome Res. 10, 1546–1560.

    Article  PubMed  Google Scholar 

  • Zhao, Y., Li, S., Childs, E. E., Kuharsky, D. K., and Yin, X. M. (2001). J. Biol. Chem. 276, 27432–27440.

    Article  PubMed  Google Scholar 

  • Zong, W. X., Lindsten, T., Ross, A. J., MacGregor, G. R., and Thompson, C. B. (2001). Genes Dev. 15, 1481–1486.

    Article  PubMed  Google Scholar 

  • Zoratti, M., and Szabo, I. (1995). Biochim. Biophys. Acta 1241, 139–176.

    PubMed  Google Scholar 

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  1. Department of Biological Regulation, Weizmann Institute of Science, Rehovot, 76100, Israel

    Atan Gross

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  1. Atan Gross
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Correspondence to Atan Gross.

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Gross, A. Mitochondrial Carrier Homolog 2: A Clue to Cracking the BCL-2 Family Riddle?. J Bioenerg Biomembr 37, 113–119 (2005). https://doi.org/10.1007/s10863-005-6222-3

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