Abstract
The etiology of autism is unclear, however autism is considered as a multifactorial disorder that is influenced by neurological, environmental, immunological and genetic factors. Growth factors, including epidermal growth factor (EGF), play an important role in the celluler proliferation and the differentiation of the central and peripheral nervous system. In this study we hypothesized that EGF may play a role in the pathophysiology of autism and examined serum EGF levels in children with autism. We measured serum levels of EGF in the 27 autistic children and 28 age- matched normal controls. The serum levels of EGF in the subjects with autism were significantly higher than those of normal control subjects. However, there were no correlations between serum EGF levels and clinical variables in the subjects with autism. This is the first report demonstrating the increased serum levels of EGF in children with autism. This study suggests that increased levels of EGF might have an importance in the pathophysiology of autism.
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References
Alexi, T., & Hefti, F. (1993). Trophic actions of transforming growth factor alpha on mesencephalic dopaminergic neurons developing in culture. Neuroscience, 55(4), 903–918.
Anlar, B., Oktem, F., Bakkaloğlu, B., Haliloğlu, M., Oguz, H., Unal, F., et al. (2007). Urinary epidermal and insulin-like growth factor excretion in autistic children. Neuropediatrics, 38, 151–153.
Ashwood, P., & Van de Water, J. (2004). A review of autism and the immune response. Clinical and developmental immunology, 11, 165–174.
Ashwood, P., Wills, S., & Van de Water, J. (2006). The immune response in autism: a new frontier for autism research. Journal of Leukocyte Biology, 80, 1–15.
Aybay, C., Karakus, R., & Yucel, A. (2006). Characterization of human epidermal growth factor in human serum and urine under native conditions. Cytokine, 35, 36–43.
Aylward, E. H., Minshew, N. J., Field, K., Sparks, B. F., & Singh, N. (2002). Effects of age on brain volume and head circumference in autism. Neurology, 59(2), 175–183.
Casper, D., & Blum, M. (1995). Epidermal growth factor and basic fibroblast growth factor protect dopaminergic neurons from glutamate toxicity in culture. Journal of Neurochemistry, 65(3), 1016–1026.
Casper, D., Mytilineou, C., & Blum, M. (1991). EGF enhances the survival of dopamine neurons in rat embryonic mesencephalon primary cell culture. Journal of Neuroscience Research, 30(2), 372–381.
Chauhan, A., & Chauhan, V. (2006). Oxidative stress in autism. Pathophysiology, 13, 171–181.
Filipek, P. A., Accardo, P., Baranek, G. T., Cook, E. H., Jr, Dawson, G., Gordon, B., et al. (1999). The screening and diagnosis of autistic spectrum disorders. Journal of Autism and Developmental Disorders, 29, 439–484.
Fombonne, E. (2003). The prevalence of autism. JAMA, 289, 87–89.
Fombonne, E. (2005). Epidemiology of autistic disorder and other pervasive developmental disorders. Journal of Clinical Psychiatry, 66, 3–8.
Futamura, T., Kakita, A., Sotoyama, H., Takahashi, H., & Nawa, H. (2003). Neonatal perturbation of neurotrophic signaling results in abnormal sensorimotor gating and social interaction in adults: implication for epidermal growth factor in cognitive development. Molecular Psychiatry, 8, 19–29.
Futamura, T., Toyooka, K., Iritani, S., Niizato, K., Nakamura, R., Tsuchiya, K., et al. (2002). Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients. Molecular Psychiatry, 7, 673–682.
Hashimoto, K., Shimizu, E., Komatsu, N., Nakazato, M., Okamura, N., Watanabe, H., et al. (2003). Increased levels of serum basic fibroblast growth factor in schizophrenia. Psychiatry Research, 120, 211–218.
Hashimoto, K., Shimizu, E., Komatsu, N., Watanabe, H., Shinoda, N., Nakazato, M., et al. (2005). No changes in serum epidermal growth factor levels in patients with schizophrenia. Psychiatry Research, 135, 257–260.
Ikeda, Y., Yahata, N., Ito, I., Nagano, M., Toyota, T., Yoshikawa, T., et al. (2008). Low serum levels of brain-derived neurotrophic factor and epidermal growth factor in patients with chronic schizophrenia. Schizophrenia Research, 101(1–3), 58–66.
Iwakura, Y., Piao, Y.-S., Mizuno, M., Takei, N., Kakita, A., Takahashi, H., et al. (2005). Influences of dopaminergic lesion on epidermal growth factor-ErbB signals in Parkinson’s disease and its model: neurotrophic implication in nigrostriatal neurons. Journal of Neurochemistry, 93, 974–983.
Mitchell, S., Brian, J., Zwaigenbaum, L., Roberts, W., Szatmari, P., Smith, I., et al. (2006). Early language and communication development of infants later diagnosed with autism spectrum disorder. Journal of Developmental and Behavioral Pediatrics, 27, 69–78.
Nelson, P. G., Kuddo, T., Song, E. Y., Dambrosia, J. M., Kohler, S., Satyanarayana, G., et al. (2006). Selected neurotrophins, neuropeptides, and cytokines: developmental trajectory and concentrations in neonatal blood of children with autism or Down syndrome. International Journal of Developmental Neuroscience, 24(1), 73–80.
Saemundsen, E., Magnusson, P., Smari, J., & Sigurdardottir, S. (2003). Autism diagnostic interview-revised and childhood autism rating scale: convergence and discrepancy in diagnosis autism. Journal of Autism and Developmental Disorders, 33, 319–328.
Schopler, E., Reichler, J., Vill, De., & RDaly, K. (1980). Towards objective classification of childhood autism: Childhood Autism Rating Scale (CARS). Journal of Autism and Developmental Disorders, 10, 91–103.
Şenol, S., İşeri, E., & Şener, Ş. (2006). Çocuk ve Ergenlerde Görülen Ruhsal bozukluklar. In N. Yüksel (Ed.), Ruhsal Hastalıklar (pp. 538–541). Ankara: Nobel Tıp Kitabevi.
Sucuoğlu, B., Öktem, F., & Gökler, B. (1996). Otistik çocukların değerlendirilmesinde kullanılan ölçeklere ilişkin bir çalışma. Psikiyatri, Psikoloji, Psikofarmakoloji, 4, 117–121.
Suzuki, K., Hashimato, K., Iwata, Y., Nakamura, K., Tsujii, M., Tsuchiya, K. J., et al. (2007). Decreased serum levels of epidermal growth factor in adult subjects with high-functioning autism. Biological Psychiatry, 62, 267–269.
Toyoda,T., Nakamura,K., Yamada,K., Thanseem,I., Anitha,A., Suda,S., et al. (2007). SNP analyses of growth factor genes EGF, TGFbeta-1, and HGF reveal haplotypic association of EGF with autism.
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005). Neuroglial activation and neuroinflammation in the brain of patients with autism. Annals of Neurology, 57, 67–81.
Wong, R. W., & Guillaud, L. (2004). The role of epidermal growth factor and its receptors in mammalian CNS. Cytokine and Growth Factor Reviews, 15, 147–156.
Xian, C. J., & Zhou, X. F. (1999). Roles of transforming growth factor-alpha and related molecules in the nervous system. Molecular Neurobiology, 20, 157–183.
Yamada, M., Ikeuchı, T., & Hatanaka, H. (1997). The neurotrophic action and signalling of epidermal growth factor. Progress in Neurobiology, 51, 19–37.
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İşeri, E., Güney, E., Ceylan, M.F. et al. Increased Serum Levels of Epidermal Growth Factor in Children with Autism. J Autism Dev Disord 41, 237–241 (2011). https://doi.org/10.1007/s10803-010-1046-3
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DOI: https://doi.org/10.1007/s10803-010-1046-3