Skip to main content
Log in

Predictors of Optimal Outcome in Toddlers Diagnosed with Autism Spectrum Disorders

  • Original paper
  • Published:
Journal of Autism and Developmental Disorders Aims and scope Submit manuscript

Abstract

A diagnosis of autism spectrum disorder (ASD) is usually taken to be permanent. In this study, 13 two-year-old children with ASD lost the diagnosis by age 4, at which time they scored within the normal range on standardized measures of cognitive and adaptive functioning. No differences were found in symptom severity, socialization, or communication between children who lost the ASD diagnosis and children who did not, but children with PDD-NOS were significantly more likely than those with full autistic disorder to move off the spectrum. The clearest distinguishing factor was motor skills at age 2. Results support the idea that some toddlers with ASD can lose their diagnosis and suggest that this is difficult to predict.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  • American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.

    Google Scholar 

  • Baranek, G. T. (1999). Autism during infancy: A retrospective video analysis of sensory-motor and social behaviors at 9–12 months of age. Journal of Autism and Developmental Disorders, 29(3), 213–224.

    Article  PubMed  Google Scholar 

  • Bayley, N. (1993). The Bayley scales of infant development (2nd ed.). San Antonio, TX: Harcourt Brace.

    Google Scholar 

  • Bono, M. A., Daley, T., & Sigman, M. (2004). Relations among joint attention, amount of intervention and language gain in autism. Journal of Autism and Developmental Disorders, 34, 494–505.

    Article  Google Scholar 

  • Cox, A., Klein, K., Charman, T., Baird, G., Baron-Cohen, S., Swettenham, J., Drew, A., & Wheelwright, S. (1999). Autism spectrum disorders at 20 and 42 months of age: Stability of clinical and ADI-R diagnosis. Journal of Child Psychology and Psychiatry and Allied Disciplines, 40, 719–732.

    Google Scholar 

  • Charman, T., Taylor, E., Drew, A., Cockerill, H., Brown, J., & Baird, G. (2005). Outcome at 7 years of children diagnosed with autism at age 2: Predictive validity of assessments conducted at 2 and 3 years of age and pattern of symptom change over time. Journal of Child Psychology and Psychiatry, 46, 500–513.

    Article  PubMed  Google Scholar 

  • Dawson, G., & Osterling, J. (1997). Early intervention in autism: Effectiveness, common elements of current approaches. In M. J. Guralnick (Ed.), The effectiveness of early intervention: Second generation research. Baltimore, MD: Brookes.

    Google Scholar 

  • Eaves, L., & Ho, H. (2004). Brief report: stability and change in cognitive and behavioral characteristics of autism through childhood. Journal of Autism and Developmental Disorders 26, 557–569.

    Article  Google Scholar 

  • Elliot, C. D. (1990). Differential ability scales. Orlando, Florida: The Psychological Corporation.

    Google Scholar 

  • Fein, D., Dixon, P., Paul, J., & Levin, H. (2005) Pervasive developmental disorder can evolve into ADHD: Case illustrations. Journal of Autism and Developmental Disorders, 35, 525–534.

    Article  PubMed  Google Scholar 

  • Fein, D., Stevens, M., Dunn, M., Waterhouse, L., Allen, D., Rapin, I., & Feinstein, C. (1999). Subtypes of pervasive developmental disorder: Clinical characteristics. Child Neurology, 5, 1–23.

    Google Scholar 

  • Gabriels, R. L., Hill, D. E., Pierce, R. A., Rogers, S. J., & Wehner, B. (2001). Predictors of treatment outcome in young children with autism: A retrospective study. Autism, 5, 407–429.

    Article  PubMed  Google Scholar 

  • Kelley, E., Paul, J., Fein, D., & Naigles, L. (2006). Residual language deficits in optimal outcome children with a history of autism. Journal of Autism and Developmental Disorders, 36(6), 807–828.

    Article  PubMed  Google Scholar 

  • Koegel, L. K., Koegel, R. L., Shoshan, Y., & McNerney, E. K. (1999). Pivotal response intervention II: Preliminary long-term outcomes data. Journal of the Association for Persons with Severe Handicaps, 24, 186–198.

    Article  Google Scholar 

  • Koegel, R. L., Koegel, L. K., & McNerney, E. K. (2001). Pivotal areas in intervention for autism. Journal of Clinical Child Psychology, 30, 19–32.

    Article  PubMed  Google Scholar 

  • Lord, C. (1995). Follow-up of two-year-olds referred for possible autism. Journal of Child and Adolescent Psychiatry, 36, 1365–1382.

    Google Scholar 

  • Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685.

    Article  PubMed  Google Scholar 

  • Lord, C., Rutter, M., DiLavore, P., & Risi, S. (1999). Autism diagnostic observation schedule-WPS edition. Los Angles, California: Western Psychological Services.

    Google Scholar 

  • Lord, C., Storoschuk, S., Rutter, M., & Pickles, A. (1993). Using the ADI-R to diagnose autism in preschool children. Infant Mental Health Journal, 14(3), 234–252.

    Google Scholar 

  • Lovaas, O. I. (1987). Behavioral treatment and normal educational and intellectual functioning in young autistic children. Journal of Counseling and Clinical Psychology, 55, 3–9.

    Article  Google Scholar 

  • McEachin, J., Smith, T., & Lovaas, I. (1993). Long-term outcome for children with autism who received early intensive behavioral treatment. American Journal of Mental Retardation, 97, 359–372.

    PubMed  Google Scholar 

  • Moore, V., & Goodson, S. (2003). How well does early diagnosis of autism stand the test of time? Follow-up study of children assessed for autism at age 2 and development of an early diagnostic service. Autism, 7, 47–63.

    PubMed  Google Scholar 

  • Mullen, E. (1995). Mullen scales of early learning. Circle Pines, MN: American Guidance Service.

    Google Scholar 

  • Osterling, J., & Dawson, G. (1994). Early recognition of children with autism: A study of first birthday home videotapes. Journal of Autism and Developmental Disorders, 24(3), 247–257.

    Article  PubMed  Google Scholar 

  • Robins, D., Fein, D., Barton, M., & Green, J. (2001). The Modified Checklist for Autism in Toddlers: An initial study investigating the early detection of autism and pervasive developmental disorders. Journal of Autism and Developmental Disorders, 31, 131–144.

    Article  PubMed  Google Scholar 

  • Rogers, S. (2001). Diagnosis of autism before the age of 3. International Review of Research in Mental Retardation, 23, 1–31.

    Article  Google Scholar 

  • Rogers S. J., Hepburn S. L., Stackhouse T., & Wehner E. (2003). Imitation performance in toddlers with autism and those with other developmental disorders. Journal of Child Psychology and Psychiatry, 44, 763–781.

    Article  PubMed  Google Scholar 

  • Sallows, G. O., & Graupner, T. D. (2005). Intensive behavioral treatment for children with autism: Four-year outcome and predictors. American Journal on Mental Retardation, 6, 417–438.

    Article  Google Scholar 

  • Schopler, E., Reichler, R., & Renner, B. (1988). The childhood autism rating scale. Los Angeles: Western Psychological Services.

    Google Scholar 

  • Sigman, M., & Ruskin, E. (1999). Continuity and change in the social competence of children with autism, down syndrome, and developmental delays. Monographs of the Society for Research in Child Development.

  • Sigman, M., & McGovern, C. W. (2005). Improvement in cognitive and language skills from preschool to adolescence in autism. Journal of Autism and Developmental Disorders, 35, 15–23.

    Article  PubMed  Google Scholar 

  • Sparrow S., Balla, D., & Cicchetti, D. (1984). The vineland adaptive behavior scales. Circles Pines, MN: American Guidance Services.

    Google Scholar 

  • Stevens, M. C., Fein, D. A., Dunn, M., Allen, D., Waterhouse, L. H., Feinstein, C., & Rapin, I. (2000). Subgroups of children with autism by cluster analysis: A longitudinal examination. Journal of the American Academy of Child and Adolescent Psychiatry, 39, 346–352.

    Article  PubMed  Google Scholar 

  • Stone, W. L., & Hogan, K. L. (1993). A structured parent interview for identifying young children with autism. Journal of Autism and Developmental Disorders, 23(4), 639–652.

    Article  PubMed  Google Scholar 

  • Stone, W. L., Lee, E. B., Ashford, L., Brissie, J., Hepburn, S. L., Coonrod, E. E., & Weiss, B. H. (1999). Can autism be diagnosed accurately in children under 3 years? Journal of Child Psychology and Psychiatry and Allied Disciplines, 40(2), 219–226.

    Google Scholar 

  • Szatmari, P., Bryson, S. E., Boyle, M. H., Streiner, D. L., & Duku, E. (2003). Predictors of outcome among high functioning children with autism and Asperger syndrome. Journal of Child Psychology and Psychiatry, 44, 520–528.

    Article  PubMed  Google Scholar 

  • Tatsuoka, M. M. (1988). Multivaraite analysis (2nd ed.). NY: Macmillan.

    Google Scholar 

  • Volkmar, F., Chawarska, K., & Klin, A. (2005). Autism in infancy and early childhood. Annual Review of Psychology, 56, 315–336.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This research was supported in part by grants from the National Institute of Child Health and Development (5 R01 HD39961), the Maternal and Child Health Bureau (5 R40 MC00270), the National Association for Autism Research, and the UCONN Research Foundation. In addition, the authors would like to thank the many graduate students and undergraduate research assistants who have assisted with this project, and the children and their families who have participated in this project.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Saasha Sutera.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sutera, S., Pandey, J., Esser, E.L. et al. Predictors of Optimal Outcome in Toddlers Diagnosed with Autism Spectrum Disorders. J Autism Dev Disord 37, 98–107 (2007). https://doi.org/10.1007/s10803-006-0340-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10803-006-0340-6

Keywords

Navigation