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History of benign breast disease and risk of breast cancer among women in China: a case–control study

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Abstract

Background

Data from the Shanghai Breast Cancer Study were analyzed to evaluate the relationship between benign breast disease (BBD) and breast cancer among Chinese women with a self-report of physician-diagnosed BBD.

Methods

Study participants consisted of 3,452 breast cancer cases and 3,474 population controls recruited by the Shanghai Breast Cancer Study. In-person interviews were conducted to collect information on demographics and suspected risk factors for breast cancer, including a detailed history of BBD. Unconditional logistic regression was used to derive adjusted odds ratios (ORadj) and 95% confidence intervals (CI) for the association between self-reported BBD and breast cancer.

Results

Women with breast cancer were significantly more likely to have a self-reported history of BBD including lobular proliferation (ORadj = 1.6; 95% CI 1.4–1.8), fibroadenoma (ORadj = 1.9; 95% CI 1.6–2.3), and other BBD (ORadj = 1.6; 95% CI 1.3–2.1). Breast cancer risk was lower for surgically treated fibroadenoma as compared to non-surgically treated and higher for other BBDs that were surgically treated versus non-surgically treated.

Conclusions

Our results suggest that personal history of BBD is associated with an increased risk of future breast cancer among women in China. Surgical intervention for fibroadenoma may reduce the risk.

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Acknowledgments

This research was supported by grant R01 CA64277 from the National Cancer Institute, USA. The authors would like to thank research team of the Shanghai Cancer Institute for their support in conducting this study. We also thank Bethanie Hull who provided assistance with the preparation of this manuscript.

Author information

Authors and Affiliations

  1. Department of Medicine, Vanderbilt Epidemiology Center, Institute of Medicine & Public Health, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Sixth Floor, Suite 600, 2525 West End Avenue, Nashville, TN, 37203-1738, USA

    Tsogzolmaa Dorjgochoo, Sandra L. Deming, Wei Zheng & Xiao Ou Shu

  2. Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China

    Yu-Tang Gao, Wei Lu, Ying Zheng & Zhixian Ruan

Authors
  1. Tsogzolmaa Dorjgochoo
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  2. Sandra L. Deming
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  3. Yu-Tang Gao
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  4. Wei Lu
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  5. Ying Zheng
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  6. Zhixian Ruan
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  7. Wei Zheng
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  8. Xiao Ou Shu
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Corresponding author

Correspondence to Xiao Ou Shu.

Appendix I

Appendix I

Categories of the College of American Pathologists classification of benign breast disease [9,10]

Pathologic category

Level of increased risk for invasive breast cancer

Pathological types included in the category

1

No increase

Adenosis (other than sclerosing adenosis)

Ductal ectasia

Fibroadenoma without complex features

Fibrosis

Mastitis

Mild hyperplasia without atypia

Ordinary cysts (gross or microscopic)

Simple apocrine metaplasia (no associated hyperplasia or adenosis)

Squamous metaplasia

2

Slightly increased

Fibroadenoma with complex features

Moderate or florid hyperplasia without atypia

Sclerosing adenosis,

Solitary papilloma without coexistent atypical hyperplasia

3

Moderately increased

Atypical ductal hyperplasia

Atypical lobular hyperplasia

4

Markedly increased

Ductal carcinoma in situ

Lobular carcinoma in situ

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Dorjgochoo, T., Deming, S.L., Gao, YT. et al. History of benign breast disease and risk of breast cancer among women in China: a case–control study. Cancer Causes Control 19, 819–828 (2008). https://doi.org/10.1007/s10552-008-9145-6

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  • DOI: https://doi.org/10.1007/s10552-008-9145-6

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