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Henipaviruses: Gaps in the Knowledge of Emergence

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Abstract

Over the past 10 years many “new” viruses have been identified in Australia and the Asian region. The viruses have been isolated from, and/or identified in, a range of animals; some of these viruses are of veterinary and medical importance while others are new threats to biodiversity. Of these viruses, Hendra and Nipah viruses have emerged as significant zoonotic agents belonging to the family Paramyxoviridae and genus Henipavirus. These agents cause fatalities in a range of animals including horses, pigs, and humans. Both viruses have been isolated from flying foxes (genus Pteropus; suborder Megachiroptera), which are accepted as their natural hosts. Although some research has been undertaken on the viruses and their hosts, little is known about how these viruses emerge. We have attempted to investigate the current knowledge of the bat-Henipavirus ecology by discussing the range of bat viruses that exist (viral assemblage), the significance of evolving viruses, possible functional role(s) of viruses, the ecology of viruses and their hosts, and identifying possible drivers (selection pressures) that may culminate with the overlap of new potential viral hosts thereby facilitating the replication of fit viral populations in a new host–virus continuum(s). By undertaking such an analysis, we have attempted to identify key questions, which should be investigated if the factors involved in “driving” Henipavirus emergence are to be understood.

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References

  • L Berger R Speare P Daszak DE Green AA Cunningham CL Goggin et al. (1998) ArticleTitleChytridiomycosis causes amphibian mortality associated with population declines in the rain forests of Australia and Central America Proceedings of the National Academy of Sciences of the United States of America 95 9031–9036

    Google Scholar 

  • KB Chua KJ Goh KT Wong A Kamarulzaman PSK Tan TG Ksiazek et al. (1999) ArticleTitleFatal encephalitis due to Nipah virus among pig-farmers in Malaysia Lancet 354 1257–1259

    Google Scholar 

  • KB Chua LF Wang K Sai Kit ParticleLam GC Crameri M Yu T Wise et al. (2001) ArticleTitleTioman virus, a novel paramyxovirus isolated from fruit bats in Malaysia Virology 283 215–229

    Google Scholar 

  • KB Chua BH Chua CW Wang (2002) ArticleTitleAnthropogenic deforestation, EI Nino and the emergence of Nipah virus in Malaysia Malaysian Journal of Pathology 24 15–21

    Google Scholar 

  • MS Crane P Hardy-Smith LM Williams AD Hyatt LM Eaton A Gould et al. (2000) ArticleTitleFirst isolation of an aquatic birnavirus from farmed and wild fish species in Australia Diseases of Aquatic Organisms 43 1–14

    Google Scholar 

  • P Daszak AA Cunningham AD Hyatt (2000) ArticleTitleEmerging infectious diseases of wildlife—threats to biodiversity and human health Science 287 443–449

    Google Scholar 

  • E Domingo E Baranowski CM Ruiz-Jarabo AM Martin-Hernandez JC Saiz C Escarmis (1998) ArticleTitleQuasispecies structure and persistence of RNA viruses Emerging Infectious Diseases 4 521–527

    Google Scholar 

  • WG Downs CR Anderson L Spence THG Aitken AH Greenhall (1963) ArticleTitleTacaribe virus, a new agent isolated from Artibeus bats and mosquitoes in Trinidad, West Indies American Journal of Tropical Medicine and Hygiene 12 640–646

    Google Scholar 

  • BT Eaton (2001) ArticleTitleIntroduction to current focus on Hendra and Nipah viruses Microbes and Infection 3 277–278

    Google Scholar 

  • HE Field PC Barratt RJ Hughes J Shield ND Sullivan (2000) ArticleTitleA fatal case of Hendra virus infection in a horse in north Queensland: clinical and epidemiological features Australian Veterinary Journal 78 279–280

    Google Scholar 

  • HE Field PL Young JM Yob JN Mills LS Hall JS MacKenzie (2001) ArticleTitleThe natural history of Hendra and Nipah viruses Microbes and Infection 3 307–314

    Google Scholar 

  • Fraser, GC, Hooper, PT, Lunt, RA, Gould, AR, Gleeson, LJ, Hyatt, AD, et al. (1996) “Encephalitis caused by lyssavirus in fruit bats in Australia” Emerging Infectious Diseases 2: 327–331

    Google Scholar 

  • Gard, GP, Marshall, ID (1973) “Nelson Bay virus. A novel reovirus” Archiv Fur Die Gesamte Virusforsch 43: 34–42

    Google Scholar 

  • AR Gould AD Hyatt RA Lunt JA Kattenbelt SG Hengstberger SD Blacksell (1998) ArticleTitleCharacterisation of a novel lyssavirus isolated from pteropid bats in Australia Virus Research 54 165–187

    Google Scholar 

  • AR Gould JA Kattenbelt P Selleck E Hansson A Della-Porta HA Westbury (2001) ArticleTitleVirulent Newcastle disease in Australia: molecular epidemiological analysis of viruses isolated prior to and during the outbreaks of 1998–2000 Virus Research 77 51–60

    Google Scholar 

  • LS Hall GC Richards (2000) Flying foxes, fruit bats and blossom bats of Australia. Australian Natural History Series UNSW Press Sydney

    Google Scholar 

  • K Halpin (2000) Genetic studies of Hendra virus and other novel paramyxoviruses (thesis) University of Queensland Brisbane, Australia

    Google Scholar 

  • K Halpin PL Young HE Field (1996) ArticleTitleIdentification of likely natural hosts for equine morbillivirus Communicable Diseases Intelligence 20 476

    Google Scholar 

  • K Halpin PL Young HE Field JS MacKenzie (1999) ArticleTitleNewly discovered viruses of flying foxes Veterinary Microbiology 68 83–87

    Google Scholar 

  • SG Hengstberger AD Hyatt R Speare BEH Coupar (1993) ArticleTitleComparison of epizootic haematopoietic necrosis and Bohle iridoviruses, recently isolated Australian iridoviruses Diseases of Aquatic Organisms 15 93–107

    Google Scholar 

  • FB Hollinger KM Pavri (1971) ArticleTitleBat parainfluenza virus: immunological, chemical, and physical properties American Journal of Tropical Medicine and Hygiene 20 131–138

    Google Scholar 

  • EC Holmes A Moya (2002) ArticleTitleIs the quasispecies concept relevant to RNA viruses? Journal of Virology 76 460–465

    Google Scholar 

  • PT Hooper AR Gould GM Russell JA Kattenbelt G Mitchell (1996) ArticleTitleThe retrospective diagnosis of a second outbreak of equine morbillivirus infection Australian Veterinary Journal 74 244–245

    Google Scholar 

  • PT Hooper PJ Ketterer AD Hyatt GM Russell (1997) ArticleTitleLesions of experimental equine morbillivirus pneumonia in horses Veterinary Pathology 34 312–322

    Google Scholar 

  • PT Hooper RA Lunt AR Gould AD Hyatt GM Russell JA Kattenbelt et al. (1999a) ArticleTitleEpidemic of blindness in kangaroos—evidence of a viral aetiology Australian Veterinary Journal 77 529–536

    Google Scholar 

  • PT Hooper GM Russell CJ Morrow Y Segal (1999b) ArticleTitleLentogenic Newcastle disease virus and respiratory disease in Australian broiler chickens Australian Veterinary Journal 77 53–54

    Google Scholar 

  • PT Hooper SR Zaki PW Daniels DJ Middleton (2001) ArticleTitleComparative pathology of the diseases caused by Hendra and Nipah viruses Microbes and Infection 3 315–322

    Google Scholar 

  • AD Hyatt PW Selleck (1996) ArticleTitleUltrastructure of equine morbillivirus Virus Research 43 1–15

    Google Scholar 

  • AD Hyatt PM Hine JB Jones RJ Whittington C Kearns TG Wise et al. (1997) ArticleTitleEpizootic mortality in the pilchard Sardinops sagax neopilchardus in Australia and New Zealand in 1995. II. Identification of a herpesvirus within the gill epithelium Diseases of Aquatic Organisms 28 17–29

    Google Scholar 

  • AD Hyatt SR Zaki CS Goldsmith T Wise SG Hengstberger (2001) ArticleTitleUltrastructure of Hendra virus and Nipah virus within cultures cells and host animals Microbes and Infection 3 297–306

    Google Scholar 

  • AD Hyatt M Williamson BE Coupar D Middleton SG Hengstberger AR Gould et al. (2002) ArticleTitleFirst identification of a ranavirus from green pythons (Chondropython viridis) Journal of Wildlife Diseases 38 239–252

    Google Scholar 

  • MJ Johara HE Field AM Rashdi C Morrissy B Heide ParticleVan der PA Rota et al. (2001) ArticleTitleNipah virus infection in bats (order Chiroptera) in peninsular Malaysia Emerging Infectious Diseases 7 439–441

    Google Scholar 

  • T Jubb (2002) ArticleTitleNewcastle disease Animal Health Surveys 7 1–2

    Google Scholar 

  • N Karabatsos (1969) ArticleTitleCharacterization of viruses isolated from bats American Journal of Tropical Medicine and Hygiene 18 803–810

    Google Scholar 

  • B Kissi H Badrane L Audry A Lavenu N Tordo M Brahimi et al. (1999) ArticleTitleDynamics of rabies virus quasispecies during serial passages in heterologous hosts Journal of General Virology 80 IssueIDPt 8 2041–2050

    Google Scholar 

  • JS Langdon JD Humphrey LM Williams AD Hyatt HA Westbury (1986) ArticleTitleFirst virus isolation from Australian fish: an iridovirus-like pathogen from redfin perch, Perca fluviatilis L Journal of Fish Diseases 9 263–268

    Google Scholar 

  • JS MacKenzie (1999) ArticleTitleEmerging viral diseases: an Australian perspective Emerging Infectious Diseases 5 1–8

    Google Scholar 

  • JG McCormack AM Allworth LA Selvey PW Selleck (1999) ArticleTitleTrransmissibility from horses to humans of a novel paramyxovirus, equine morbillivirus (EMV) Journal of Infection 38 22–32

    Google Scholar 

  • SP Mickleburgh AM Hutson P Racey InstitutionalAuthorNameIUCNSSC Chiroptera Specialist Group (1992) Old World Fruit Bats: an Action Plan for Their Conservation IUCN Gland, Switzerland

    Google Scholar 

  • DJ Middleton HA Westbury C Morrissy B Heide ParticleVan der GM Russell MA Braun et al. (2000) Experimental Nipah virus disease in pigs: clinical features, virus excretion and subclinical infection C Cargill S McOrist (Eds) Proceedings of the 16th International Pig Veterinary Society Congress September 17–21, 2000 International Pig Veterinary Society, Ocean Grove, Victoria Australia 552

    Google Scholar 

  • DJ Middleton HA Westbury C Morrissy B Heide Particlevan der GM Russell MA Braun et al. (2002) ArticleTitleExperimental nipah virus infection in pigs and cats Journal of Comparative Pathology 126 124–136

    Google Scholar 

  • BL Munday JS Langdon A Kyatt JD Humphrey (1992) ArticleTitleMass mortality associated with a viral-induced vacuolating encephalopathy and retinopathy of larval and juvenile barramundi, Lates calcarifer Bloch Aquaculture 103 197–211

    Google Scholar 

  • AG Murray M O’Callaghan B Jones (2001) ArticleTitleSimple models of massive epidemics of herpesvirus in Australian (and New Zealand) pilchards Environment International 27 243–248

    Google Scholar 

  • PK Murray PW Selleck PT Hooper AD Hyatt AR Gould LJ Gleeson et al. (1995) ArticleTitleA morbillivirus that caused fatal disease in horses and humans Science 268 94–97

    Google Scholar 

  • J Olson C Rupprecht PE Rollin US An M Niezgoda T Clemins et al. (2002) ArticleTitleAntibodies to Nipah-like virus in bats (Pteropus lylei), Cambodia Emerging Infectious Diseases 8 987–988

    Google Scholar 

  • JD O’Sullivan AM Allworth DL Paterson TM Snow R Boots LJ Gleeson et al. (1997) ArticleTitleFatal encephalitis due to novel paramyxovirus transmitted from horses Lancet 349 93–95

    Google Scholar 

  • NI Paton YS Leo SR Zaki AP Auchus KE Lee AE Ling et al. (1999) ArticleTitleOutbreak of Nipah-virus infection among abattoir workers in Singapore Lancet 354 1253–1256

    Google Scholar 

  • BP Peeters OS Leeuw Particlede G Koch AL Gielkens (1999) ArticleTitleRescue of Newcastle disease virus from cloned cDNA: evidence that cleavability of the fusion protein is a major determinant for virulence Journal of Virology 73 5001–5009

    Google Scholar 

  • AW Philbey PD Kirkland AD Ross RJ Davis AB Gleeson RJ Love et al. (1998) ArticleTitleAn apparently new virus (family paramyxoviridae) infectious for pigs, humans and fruit bats Emerging Infectious Diseases 4 269–271

    Google Scholar 

  • RJ Rogers IC Douglas FC Baldock RJ Glanville KT Seppanen LJ Gleeson et al. (1996) ArticleTitleInvestigation of a second focus of equine morbillivirus infection in coastal Queensland Australian Veterinary Journal 74 243–244

    Google Scholar 

  • Rota, PA, Harcourt, BH, Rollin, PE, Widjojoatmodjo, Bellini, WJ, Chua, KB et al. (1999) “Molecular characterization of a Hendra-like virus (Nipah virus) isolated from fatal encephalitis cases in Malaysia and Singapore” in: XIth International Congress of Virology Abstracts Book, August 9–13, 1999, International Union of Microbiological Societies, Sydney, Australia

  • CM Ruiz-Jarabo A Arias E Baranowski C Escarmis E Domingo (2000) ArticleTitleMemory in viral quasispecies Journal of Virology 74 3543–3547

    Google Scholar 

  • SL Rutherford S Lindquist (1998) ArticleTitleHsp90 as a capacitor for morphological evolution Nature 396 336–342

    Google Scholar 

  • LA Selvey RM Wells JG McCormack AJ Ansford PK Murray RJ Rogers et al. (1995) ArticleTitleInfection of humans and horses by a newly described morbillivirus Medical Journal of Australia 162 642–645

    Google Scholar 

  • S Shahirudin M Zamri-Saad S Shamshad AH Mahani Y Harizam B Norazian et al. (1999) A novel clinicopathological disorder associated with a zoonotic paramyxovirus infection in pigs Seminar on Nipah Virus: Latest Updates in the Diagnosis Treatment and Control in Humans and Animals Veterinary Association of Malaysia Melaka, Malaysia

    Google Scholar 

  • RE Shope (1982) ArticleTitleRabies-related viruses Yale Journal of Biology and Medicine 55 271–275

    Google Scholar 

  • EA Sinclair NJ Webb AD Marchant CR Tidemann (1996) ArticleTitleGenetic variation in the little red flying-fox, Pteropus scapulatos (Chiroptera: Pteropodidae): implications for management Biological Conservation 76 45–50

    Google Scholar 

  • SE Sulkin R Allen (1974) Virus infection in bats, Vol 8 Monographs in Virology, Karger Basel

    Google Scholar 

  • B Tandler (1996) ArticleTitleCytomegalovirus in the principal submandibular gland of the little brown bat, Myotis lucifugus Journal of Comparative Pathology 114 1–9

    Google Scholar 

  • LF Wang M Yu E Hansson LI Pritchard BJ Shiell WP Michalski et al. (2000) ArticleTitleThe exceptionally large genome of Hendra virus: support for creation of a new genus within the family paramyxoviridae Journal of Virology 74 9972–9979

    Google Scholar 

  • MP Ward PF Black AJ Childs FC Baldock WR Webster BJ Rodwell et al. (1996) ArticleTitleNegative findings from serological studies of equine morbillivirus in the Queensland horse population Australian Veterinary Journal 74 241–243

    Google Scholar 

  • NJ Webb CR Tidemann (1996) ArticleTitleMobility of Australian flying-foxes, Pteropus spp. (Megachiroptera): evidence from genetic variation Proceedings of the Royal Society of London. Series B: Biological Sciences 263 497–502

    Google Scholar 

  • Weir, RP (2002) Classification and identification of viruses isolated from mosquitoes in the Northern Territory, 1982–1992, using a range of techniques, thesis, University of Sydney, Faculty of Medicine, Sydney, Australia

  • RJ Whittington C Kearns AD Hyatt S Hengstberger T Rutzou (1996) ArticleTitleSpread of epizootic haematopoietic necrosis virus (EHNV) in redfin perch (Perca fluviatilis) in southern Australia Australian Veterinary Journal 73 112–114

    Google Scholar 

  • RJ Whittington JB Jones PM Hine AD. Hyatt (1997) ArticleTitleEpizootic mortality in the pilchard Sardinops sagax neopilchardus in Australia and New Zealand in 1995. I. Pathology and epizootiology Diseases of Aquatic Organisms 28 1–16

    Google Scholar 

  • MM Williamson PT Hooper PW Selleck LJ Gleeson PW Daniels HA Westbury et al. (1998) ArticleTitleTransmission studies of Hendra virus (equine morbillivirus) in fruit bats, horses and cats Australian Veterinary Journal 76 813–818

    Google Scholar 

  • MM Williamson PT Hooper PW Selleck HA Westbury RF Slocombe (2001) ArticleTitleA guinea pig model of Hendra virus encephalitis Journal of Comparative Pathology 124 273–279

    Google Scholar 

  • Wise, T, Hyatt, A, Chua, KB, Weir, R (2002) “Characterisation of bat retroviruses by electron microscopy” In: 17th Australian Conference on Electron Microscopy, Adelaide, Australia, February 4–8, 2002, pp 48

  • PL Young K Halpin PW Selleck HE Field JL Gravel MA Kelly et al. (1996) ArticleTitleSerologic evidence for the presence in Pteropus bats of a paramyxovirus related to equine morbillivirus Emerging Infectious Diseases 2 239–240

    Google Scholar 

  • AA Zubaid (1993) ArticleTitleComparison of the bat fauna between a primary and fragmented secondary forest in peninsula Malaysia Mammalia 57 201–206

    Google Scholar 

Download references

Acknowledgments

This work was funded in part by core funding to the Consortium for Conservation Medicine from the V. Kann Rasmussen Foundation and by an NIH/NSF “Ecology of Infectious Diseases” Award via the John E. Fogarty International Center, NIH TWO5869 to P.D.

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Authors and Affiliations

  1. Australian Animal Health Laboratory (AAHL), CSIRO, Livestock Industries, P.O. Bag 24, Geelong, Victoria 3220, Australia

    Alex D. Hyatt & Allan R. Gould

  2. Consortium for Conservation Medicine, Wildlife Trust, 61 Route 9 W, Palisades, NY 10964-8000, USA

    Peter Daszak

  3. Zoological Society of London, Institute of Zoology, Regent’s Park, London NW1 4RY, UK

    Andrew A. Cunningham

  4. Queensland Department of Primary Industries, Animal Research Institute, LMB 4 Moorooka 4105, Brisbane, Australia

    Hume Field

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  1. Alex D. Hyatt
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  2. Peter Daszak
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  3. Andrew A. Cunningham
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  4. Hume Field
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  5. Allan R. Gould
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Correspondence to Alex D. Hyatt.

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Hyatt, A.D., Daszak, P., Cunningham, A.A. et al. Henipaviruses: Gaps in the Knowledge of Emergence. EcoHealth 1, 25–38 (2004). https://doi.org/10.1007/s10393-004-0017-6

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