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Lack of association between GRIA1 polymorphisms and haplotypes with migraine without aura or response to triptans

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Abstract

The present study was designed to replicate previous findings reporting a significant association between the rs548294 polymorphism at the glutamate receptor subunit GluR1 gene (GRIA1) and migraine without aura, either as a single marker or in haplotype combination with rs2195450. In addition, the role of GRIA1 polymorphisms and haplotypes was evaluated in migraine patients without aura as predictive factors for consistency in headache response to triptans. Analysis of rs548294 and rs2195450 polymorphisms of GRIA1 was conducted by Real-time PCR allelic discrimination assay in 186 migraine patients without aura and 312 healthy controls, respectively. In the logistic regression analysis adjusted for gender and age, genotype and haplotype frequencies for the two polymorphisms did not significantly differ between migraine patients without aura and controls. In addition, no evidence of association was found between GRIA1 polymorphisms/haplotypes and consistent response to triptans. This study failed to replicate previously reported association between GRIA1 rs548294 and migraine without aura, either as single marker or when analyzed in haplotype combination with rs2195450. In addition, no evidence was found for a relevant role of GRIA1 polymorphisms and haplotypes as modulating factors of headache response to triptans.

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Acknowledgments

This work was funded by grants from Regione Piemonte, Ricerca Sanitaria Finalizzata to AAG (2006) and to PLC (2003, 2007 and 2008), from the Italian Ministry of Health (RC2010) to IRCCS ‘National Neurological Institute C. Mondino’ Foundation, and from Fondazione della Comunità del Novarese. S.C. holds a Ph.D fellowship supported by the Compagnia di San Paolo.

Conflict of interest

The authors report no conflict of interest.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Università del Piemonte Orientale “A. Avogadro”, Largo Donegani 2, 28100, Novara, Italy

    Sarah Cargnin, Pier Luigi Canonico & Salvatore Terrazzino

  2. Headache Science Centre, National Neurological Institute C. Mondino, Pavia, Italy

    Michele Viana, Cristina Tassorelli & Giuseppe Nappi

  3. Division of Neurology, Maggiore Hospital, Università del Piemonte Orientale, Novara, Italy

    Daniela Mittino

  4. Department of Medical Sciences, Università del Piemonte Orientale, Novara, Italy

    Giorgio Bellomo

  5. Department of Brain and Behaviour, University of Pavia, Pavia, Italy

    Cristina Tassorelli

Authors
  1. Sarah Cargnin
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  2. Michele Viana
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  3. Daniela Mittino
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  4. Giorgio Bellomo
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  5. Cristina Tassorelli
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  6. Giuseppe Nappi
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  7. Pier Luigi Canonico
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  8. Salvatore Terrazzino
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Corresponding author

Correspondence to Salvatore Terrazzino.

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Cargnin, S., Viana, M., Mittino, D. et al. Lack of association between GRIA1 polymorphisms and haplotypes with migraine without aura or response to triptans. Neurol Sci 35, 421–427 (2014). https://doi.org/10.1007/s10072-013-1535-1

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  • DOI: https://doi.org/10.1007/s10072-013-1535-1

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