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Predictive index for the onset of medication overuse headache in migraine patients

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Abstract

Migraine patients are particularly prone to develop medication overuse headache (MOH). However, the risk factors for the transformation of migraine to MOH are still not clear. We investigated gene polymorphisms, personality traits, and characteristics of headache and lifestyle in 47 migraine patients (aged 36.4 ± 10.3) and 22 MOH patients (aged 39.6 ± 9.9) who progressed from migraine and made a scoring system for a predictive index (PI) of the onset of MOH in patients with migraine. By multivariate logistic stepwise regression analysis, type of migraine, regular and sufficient dietary intake, and methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) and dopamine D2 receptor (DRD2) C939T (rs6275) polymorphisms were selected as significant factors that contribute independently to the development from migraine to MOH (P < 0.05). The regression coefficients (β) of these four selected factors were approximated and scored. The PI score in MOH patients (7.32 ± 1.60) was significantly higher than that in migraine patients (4.62 ± 1.83, P < 0.001). The proposed scoring system should in the future be the object of larger studies to confirm its validity.

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Acknowledgments

We thank Dr. Hideto Oyamada (Department of Pharmacology, Showa University School of Medicine) and Ms. Yuika Naito (Department of Pharmacy, Showa University Hospital) for technical support. This study was supported by the Tamagawa University Center of Excellence under the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) (M.K.); Core Research for Evolutionary Science and Technology (CREST17022035) (M.K.); a Grant-in-Aid for Scientific Research on Innovative Areas, “Face perception and recognition,” from MEXT (21119518) (M.K.); a Grant-in-Aid for Scientific Research on Priority Areas: System Study on High-Order Brain Functions from Showa University Grant-in-Aid for Innovative Collaborative Research Projects; a Special Research Grant-in-Aid for Development of Characteristic Education from MEXT (M.K.); a Grant of Private University High Technology Research Center Project matching fund subsidy from MEXT.

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Authors and Affiliations

  1. Department of Pathophysiology, Showa University School of Pharmacy, Tokyo, 142-8555, Japan

    T. Onaya, M. Ishii & S. Shimizu

  2. Department of Neurology, Showa University School of Medicine, Tokyo, 142-8666, Japan

    H. Katoh, H. Kasai & M. Kawamura

  3. Center of Pharmaceutical Education, Showa University School of Pharmacy, Tokyo, 142-8555, Japan

    Y. Kiuchi

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  1. T. Onaya
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  2. M. Ishii
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Correspondence to M. Ishii.

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T. Onaya, M. Ishii and H. Katoh contributed equally to this work.

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Onaya, T., Ishii, M., Katoh, H. et al. Predictive index for the onset of medication overuse headache in migraine patients. Neurol Sci 34, 85–92 (2013). https://doi.org/10.1007/s10072-012-0955-7

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  • DOI: https://doi.org/10.1007/s10072-012-0955-7

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