Fixed-Parameter Algorithms for CLOSEST STRING and Related Problems

Abstract

CLOSEST STRING is one of the core problems in the field of consensus word analysis with particular importance for computational biology. Given k strings of the same length and a nonnegative integer d , find a ``center string'' s such that none of the given strings has the Hamming distance greater than d from s . CLOSEST STRING is NP-complete. In biological applications, however, d is usually very small. We show how to solve CLOSEST STRING in linear time for fixed d —the exponential growth in d is bounded by O(dd) . We extend this result to the closely related problems d -MISMATCH and DISTINGUISHING STRING SELECTION. Moreover, we also show that CLOSEST STRING is solvable in linear time when k is fixed and d is arbitrary. In summary, this means that CLOSEST STRING is fixed-parameter tractable with respect to parameter d and with respect to parameter k . Finally, the practical usefulness of our findings is substantiated by some experimental results.