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Activating L265P mutations of the MYD88 gene are common in primary central nervous system lymphoma

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References

  1. Courts C, Montesinos-Rongen M, Martin-Subero JI et al (2007) Transcriptional profiling of the nuclear factor-kappaB pathway identifies a subgroup of primary lymphoma of the central nervous system with low BCL10 expression. J Neuropathol Exp Neurol 66:230–237

    Article  PubMed  CAS  Google Scholar 

  2. Deckert M, Engert A, Brück W et al. (2011) Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma. Leukemia: doi: 10.1038/leu.2011.1169

  3. Deckert M, Paulus W (2007) Malignant Lymphomas. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) WHO classification of tumors pathology and genetics of tumours of the nervous system 4th edn. IRAC, Lyon, pp 188–192

    Google Scholar 

  4. Kluin P, Deckert M, Ferry JA (2008) Primary diffuse large B-cell lymphoma of the CNS. In: Swerdlow SH, Campo E, Harris NL et al (eds) WHO classification of tumours of haematopoietic and lymphoid tissues. IARC, Lyon, pp 240–241

    Google Scholar 

  5. Montesinos-Rongen M, Schmitz R, Brunn A et al (2010) Mutations of CARD11 but not TNFAIP3 may activate the NF-kappaB pathway in primary CNS lymphoma. Acta Neuropathol 120:529–535

    Article  PubMed  CAS  Google Scholar 

  6. Montesinos-Rongen M, Siebert R, Deckert M (2009) Primary lymphoma of the central nervous system: just DLBCL or not? Blood 113:7–10

    Article  PubMed  CAS  Google Scholar 

  7. Ngo VN, Young RM, Schmitz R et al (2011) Oncogenically active MYD88 mutations in human lymphoma. Nature 470:115–119

    Article  PubMed  CAS  Google Scholar 

  8. Puente XS, Pinyol M, Quesada V et al (2011) Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 475:101–105

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

The excellent technical assistance of Hatice Önder is appreciated. This work was supported by grants from the Deutsche Krebshilfe/Dr. Mildred Scheel-Stiftung für Krebsforschung (grant no.: 109471), the Deutsche Forschungsgemeinschaft (grant no.: De 485/9-1), and the Marga und Walter Boll-Stiftung (grant no.: 210-01-10).

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The authors declare no conflict of interest.

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Correspondence to Manuel Montesinos-Rongen.

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Montesinos-Rongen, M., Godlewska, E., Brunn, A. et al. Activating L265P mutations of the MYD88 gene are common in primary central nervous system lymphoma. Acta Neuropathol 122, 791–792 (2011). https://doi.org/10.1007/s00401-011-0891-2

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