Skip to main content
SpringerLink
Log in

Radiologic–pathologic correlations of intratumoral tissue components in the most common solid and cystic renal tumors. Pictorial review

  • Urogenital
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

This paper describes the correlation between US-CT images and pathologic findings in the most common solid and cystic renal tumors, to better differentiate malignant and benign renal masses. Several intratumoral tissue components present correlation with US-CT images. Macroscopic components, corresponding to necrotic, hemorrhagic and cystic changes, are identified by visual analysis of the gross specimen, while microscopic components are identified by histopathologic analysis. Microscopic components are classified as cellular [(1) high cellularity with poor extracellular stroma, ±high nucleus–cytoplasm ratio±high uniformity in tumoral cells dimensions; (2) low cellularity with large extracellular stroma±low nucleus–cytoplasm ratio±low uniformity in tumoral cells dimensions], stromal [(1) fibrotic; (2) fibrovascular; (3) fibromyxoid], vascular related to neoangiogenesis, necrotic [(1) coagulative; (2) colliquative; (3) hemorrhagic], calcific, and adipose.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
Fig. 13
Fig. 14

Similar content being viewed by others

References

  1. Pickhardt PJ, Lonergan GJ, Davis CJ, Kashitani N, Wagner BJ (2000) From the archives of AFIP. Infiltrative renal lesions: radiologic–pathologic correlation. Radiographics 20:215–243

    Google Scholar 

  2. Levin E, King BF (2000) Adult malignant renal parenchymal neoplasms. In: Pollack HM, McClennan BL, Dyer R (eds) Clinical urography. Saunders, Philadelphia, pp 1440–1470

    Google Scholar 

  3. Dalla Palma L, Pozzi Mucelli F, Di Donna A, Pozzi Mucelli R (1990) Cystic renal tumors: US and CT findings. Urol Radiol 12:67–73

    Google Scholar 

  4. Storkel S, Eble JN, Adlakha K et al. (1997) Classification of renal cell carcinoma: workgroup no. 1—Union Internationale Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC). Cancer 80:987–989

    Article  CAS  PubMed  Google Scholar 

  5. Oyen R (1998) Renal Parenchymal tumours. Halley Project 1998–2000, 2nd refresher course series. Springer, Milan, Italy

    Google Scholar 

  6. Oyen R, Verswijvel G, Van Poppel H, Roskams T (2001) Primary malignant renal parenchymal epithelial neoplasms. Eur Radiol 11(Suppl 2):S205–S217

    Google Scholar 

  7. Pavlovich CP, Schmidt LS, Phillips JL (2003) The genetics basis of renal cell carcinoma. Urol Clin N Am 30:437–454

    Google Scholar 

  8. Helenon O, Merran S, Paraf F et al. (1997) Unusual fat-containing tumors of the kidney: a diagnostic dilemma. Radiographics 17:129–144

    PubMed  Google Scholar 

  9. Choyke PL, Glenn GM, Walther MM, Zbar B, Linehan WM (2003) Hereditary renal cancers. Radiology 226:33–46

    Google Scholar 

  10. Soyer P, Dufresne AC, Klein I, Barbagelatta M, Herve JM, Scherrer A (1997) Renal cell carcinoma of clear cell type: correlation of CT features with tumor size, architectural patterns and pathologic staging. Eur Radiol 7:224–229

    Article  Google Scholar 

  11. Amin MB, Corless CL, Renshaw AA, Tickoo SK, Kubus J, Schultz DS (1997) Papillary (chromophil) renal cell carcinoma: histomorphologic characteristics and evaluation of conventional pathologic prognostic parameters in 62 cases. Am J Surg Pathol 21:621–635

    Article  Google Scholar 

  12. Choyke PL, Walther MM, Glenn GM et al. (1997) Imaging features of hereditary papillary renal cancers. J Comput Assist Tomogr 21:737–741

    Article  Google Scholar 

  13. Crotty TB, Farrow GM, Lieber MM (1995) Chromophobic cell renal carcinoma: clinicopathologic features of 50 cases. J Urol 154:964–967

    Article  Google Scholar 

  14. Jinzaki M, Tanimoto A, Mukai M et al. (2000) Double-phase helical CT of small renal parenchymal neoplasms: correlation with pathologic findings and tumor angiogenesis. J Comput Assist Tomogr 24:835–842

    Article  CAS  PubMed  Google Scholar 

  15. Fukuya T, Honda H, Goto K, Ono M et al. (1996) Computed tomographic findings of Bellini duct carcinoma of the kidney. J Comput Assist Tomogr 20:399–403

    Article  Google Scholar 

  16. Wagner BJ, Wong You Cheong JJ, Davis CJ (1997) From the archives of the AFIP. Adult renal hamartomas. Radiographics 17:155–169

    Google Scholar 

  17. Sherman JL, Hartman DS, Friedman AC et al. (1981) Angiomyolipomas: CT-pathologic correlations of 17 cases. Am J Roentgenol 137:1221–1226

    Google Scholar 

  18. Israel G, Bosniak MA (2003) Renal imaging for diagnosis and staging of renal cell carcinoma. Urol Clin N Am 30:499–514

    Google Scholar 

  19. Hartman DS (2001) Benign renal and adrenal tumors. Eur Radiol 11(Suppl 2):S195–S204

    Google Scholar 

  20. Riccabona M (2003) Imaging of renal tumours in infancy and childhood. Eur Radiol 13(Suppl 4):L116–L129

    Google Scholar 

  21. Amin MB, Crotty TB, Tickoo SK, Farrow GM (1997) Renal oncocytoma: a reappraisal of morphologic features with clinicopathologic findings in 80 cases. Am J Surg Pathol 21:1–12

    Article  Google Scholar 

  22. Mahnken AH, Günther RW, Tacke J (2004) Radiofrequency ablation of renal tumors. Eur Radiol 14(8):1449–1455

    Article  Google Scholar 

  23. Chomas JE, Pollard RE, Sadlowski AR, Griffey SM, Wisner ER, Ferrara KW (2003) Contrast-enhanced US of microcirculation of superficially implanted tumors in rats. Radiology 229:439–446

    Google Scholar 

  24. Quaia E, Siracusano S, Bertolotto M et al. (2003) Characterization of renal tumours with pulse inversion harmonic imaging by intermittent high mechanical index technique: initial results. Eur Radiol 13(6):1402–1412

    PubMed  Google Scholar 

  25. Lussanet QG, Backes WH, Griffionen AW et al. (2003) Gadopentetate dimeglumine versus ultrasmall superparamagnetic iron oxide for dynamic contrast-enhanced MR imaging of tumor angiogenesis in human colon carcinoma in mice. Radiology 229:429–438

    Google Scholar 

  26. Turetschek K, Huber S, Floyd E et al. (2001) MR imaging characterization of microvessels in experimental breast tumors by using a particulate contrast agent with histopathologic correlation. Radiology 218:562–569

    CAS  PubMed  Google Scholar 

  27. van Dijke CT, Brasch RC, Roberts TP et al. (1996) Mammary carcinoma model: correlation of macromolecular contrast-enhanced MR imaging characterizations of tumoral microvasculature and histologic capillary density. Radiology 198:813–818

    PubMed  Google Scholar 

  28. Olsen OE, Jeanes AC, Sebire NJ et al. (2004) Changes in computed tomography features following preoperative chemotherapy for nephroblastoma: relation to histopathological classification. Eur Radiol 14(6):990–994

    Article  Google Scholar 

  29. Helenon O, Chretien Y, Paraf F et al. (1993) Renal cell carcinoma containing fat: demonstration with CT. Radiology 188:429–430

    Google Scholar 

  30. D’Angelo PC, Gash JR, Horn AW et al. (2002) Fat in renal cell carcinoma that lack associated calcifications. Am J Roentgenol 178:931–932

    Google Scholar 

  31. Kido T, Yamashita Y, Sumi S et al. (1997) Chemical shift GRE MRI of renal angiomyolipoma. J Comput Assist Tomogr 21(2):268–270

    Article  Google Scholar 

  32. Yoshimitsu K, Honda H, Kuroiuna T et al. (1999) MR detection of cytoplasmic fat in renal cell carcinoma utilizing chemical shift GE imaging. J Magn Reson Imaging 9(4):579–585

    Google Scholar 

  33. Hartman DS (ed)(1989) Renal cystic disease. AFIP atlas of radiologic–pathologic correlations. Saunders Company, Philadelphia, USA

    Google Scholar 

  34. Bosniak MA (1986) The current radiological approach to renal cyst. Radiology 158:1–10

    CAS  PubMed  Google Scholar 

  35. Israel G, Bosniak MA (2003) Calcification in cystic renal masses: is it important in diagnosis? Radiology 226:47–52

    PubMed  Google Scholar 

  36. Roberts SC, Winick AB, Santi MR (1997) Papillary renal cell carcinoma: diagnostic dilemma of a cystic renal mass. Radiographics 17:993–998

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Cattinara Hospital, University of Trieste, Strada di Fiume 447, 34149, Trieste, Italy

    Emilio Quaia & Maria Cova

  2. Department of Pathology, University of Trieste, Trieste, Italy

    Rossana Bussani

  3. Department of Radiology, Hospital G.B. Rossi, University of Verona, Piazza L.A. Scuro 10, 37134, Verona, Italy

    Roberto Pozzi Mucelli

Authors
  1. Emilio Quaia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rossana Bussani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Maria Cova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Roberto Pozzi Mucelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Emilio Quaia.

Additional information

Presented as educational exhibit in EPOS 2004 and awarded by Cum Laude at ECR 2004

Rights and permissions

Reprints and permissions

About this article

Cite this article

Quaia, E., Bussani, R., Cova, M. et al. Radiologic–pathologic correlations of intratumoral tissue components in the most common solid and cystic renal tumors. Pictorial review. Eur Radiol 15, 1734–1744 (2005). https://doi.org/10.1007/s00330-005-2698-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00330-005-2698-9

Keywords

Search

Navigation