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Interleukin-17F gene polymorphisms in Korean patients with Behçet’s disease

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Abstract

IL-17 is a novel cytokine that is characterized by an ability to induce several types of cells to secrete proinflammatory cytokines in various inflammatory diseases. This study analyzed the influence of IL-17F gene polymorphisms on disease susceptibility and clinical features. Ninety-nine Behçet’s disease (BD) patients and 114 controls were genotyped to analyze three single nucleotide polymorphisms (SNPs) including A126G, G155A, and A161G of the IL-17F gene using automated sequencing. We compared the frequencies of IL-17F alleles, genotypes, and haplotypes in patients with BD and controls using the chi-square or Fisher’s exact test. Significant differences in the frequencies of allele and genotype in A126G SNP of IL-17 gene were found between BD patients and controls (P < 0.001 and P < 0.001, respectively). None of three IL-17F SNPs were associated with diverse clinical features in BD. The frequency of haplotype AA did not differ between patients with BD and controls (P = 0.985). The haplotypes, AG, and GG, have positive and inverse association with BD susceptibility (P < 0.001 and P < 0.001, respectively). These findings suggest that IL-17 gene SNPs may influence the susceptibility of BD.

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Authors and Affiliations

  1. Department of Chemistry, School of Advanced Science, Dankook University, Cheonan, South Korea

    Won-Cheoul Jang, Yun-Hyoung Nam, Young-Chang Ahn & Sang-Hyun Lee

  2. Department of Internal Medicine, Catholic University of Daegu School of Medicine, 3056-6 Daemyung 4-Dong, Namgu, Daegu, 705-718, South Korea

    Sung-Hoon Park, Jung-Yoon Choe & Seong-Kyu Kim

  3. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea

    Shin-Seok Lee

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  1. Won-Cheoul Jang
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Correspondence to Seong-Kyu Kim.

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Jang, WC., Nam, YH., Ahn, YC. et al. Interleukin-17F gene polymorphisms in Korean patients with Behçet’s disease. Rheumatol Int 29, 173–178 (2008). https://doi.org/10.1007/s00296-008-0664-y

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  • DOI: https://doi.org/10.1007/s00296-008-0664-y

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