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Antibody to CCDC104 is associated with a paraneoplastic antibody to CDR2 (anti-Yo)

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Abstract

Patients with cancer may develop paraneoplastic neurological syndromes (PNS) in which onconeural antibodies are important diagnostic findings. As the functional role of onconeural antibodies is largely unknown, insight gained by identifying associated antibodies may help to clarify the pathogenesis of the PNS. In this study, we identified patients with Yo antibodies who also had antibodies to an uncharacterized protein called coiled-coil domain-containing protein 104 (CCDC104). We found a significant association between CCDC104 and Yo antibodies (4 of 38, 10.5%), but not other onconeural antibodies (0 of 158) (P = 0.007, Fisher’s exact test). The prevalence of CCDC104 antibodies was approximately similar in patients with cancer (8 of 756, 1.1%) and in healthy blood donors (2 of 300, 0.7%). CCDC104 antibodies were not associated with PNS, as this was found in only two of the ten CCDC104-positive patients. The CCDC104 protein, whose function is unknown, is expressed in various human tissues, including the brain, and is localized mainly to the nucleus, but is also found in the cytoplasm. The association between Yo and CCDC104 antibodies may indicate functional similarities.

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Acknowledgments

We thank the Western Norway Regional Health Authority (Helse Vest) and the Gerda Meyer, Nyquist Guldbranson and Gerdt Meyer Nyquist legacy for financial support. We thank Kibret Mazengia, Emilia Lohndal and Sue Olsen for technical assistance and Jan Aarseth for statistical help. We also thank Lars Drivsholm, Storstrømmens Hospital, Helga Salvesen and Per E. Lønning, Haukeland University Hospital, for sera and clinical information regarding the different tumor patients.

Conflict of interest statement

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Neurology, Haukeland University Hospital, Bergen, Norway

    Cecilie Totland, Mette Haugen & Christian A. Vedeler

  2. Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway

    Geir Bredholt & Bjørn Ivar Haukanes

  3. Department of Clinical Medicine, University of Bergen, Bergen, Norway

    Christian A. Vedeler

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  1. Cecilie Totland
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  2. Geir Bredholt
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Correspondence to Cecilie Totland.

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Totland, C., Bredholt, G., Haugen, M. et al. Antibody to CCDC104 is associated with a paraneoplastic antibody to CDR2 (anti-Yo). Cancer Immunol Immunother 59, 231–237 (2010). https://doi.org/10.1007/s00262-009-0742-3

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