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Combined trans- and periurethral injections of bulking agents for the treatment of intrinsic sphincter deficiency

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Abstract

The purpose of this study was to compare Contigen combined with Durasphere to Contigen injections alone for the treatment of stress urinary incontinence (SUI) with intrinsic sphincter deficiency (ISD). Subjective and objective incontinence outcomes were compared at 2 weeks and 6 months. We compared rates of urinary retention and future incontinence surgery between groups. Thirty-three women underwent combined injections, and 51 underwent Contigen injections. Two weeks postoperatively, more women in the combined group were cured (72.7 vs. 39.2%, P = 0.003), but this difference diminished at 6 months (33.3 vs. 29.4%, P = 0.70). Retention was more common in the combined group (P = 0.002, odds ratio [OR] = 0.062 [95% confidence interval {CI} = 0.007, 0.52]). Twenty-three women in the Contigen and ten in the combined group underwent subsequent incontinence surgery (P = 0.17, OR = 2.03 [95% CI = 0.80, 5.1]). Combining Contigen and Durasphere injections to treat SUI with ISD does not improve outcomes compared to Contigen injections alone.

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References

  1. Poon CI, Zimmern PE, Wilson TS, Defreitas GA, Foreman MR (2005) Three-dimensional ultrasonography to assess long-term durability of periurethral collagen in women with stress urinary incontinence due to intrinsic sphincter deficiency. Urology 65:60–64

    Article  PubMed  Google Scholar 

  2. Tschopp PJ, Wesley-James T, Spekkens A, Lohfeld L (1999) Collagen injections for urinary stress incontinence in a small urban urology practice: time to failure analysis of 99 cases. J Urol 162:779–782

    Article  PubMed  CAS  Google Scholar 

  3. Chrouser KL, Fick F, Goel A, Itano NB, Sweat SD, Lightner DJ (2004) Carbon coated zirconium beads in beta-glucan gel and bovine glutaraldehyde cross-linked collagen injections for intrinsic sphincter deficiency: continence and satisfaction after extended follow-up. J Urol 171:1152–1155

    Article  PubMed  CAS  Google Scholar 

  4. Pannek J, Brands FH, Senge T (2001) Particle migration after transurethral injection of carbon coated beads for stress urinary incontinence. J Urol 166:1350–1353

    Article  PubMed  CAS  Google Scholar 

  5. Erekson EA, Sung VW, Rardin CR, Myers DL (2007) Ethylene vinyl alcohol copolymer erosions after use as a urethral bulking agent. Obstet Gynecol 109:490–492

    PubMed  CAS  Google Scholar 

  6. Schulz JA, Nager CW, Stanton SL, Baessler K (2004) Bulking agents for stress urinary incontinence: short-term results and complications in a randomized comparison of periurethral and transurethral injections. Int Urogynecol J Pelvic Floor Dysfunct 15:261–265

    PubMed  Google Scholar 

  7. Chapple CR, Brubaker L, Haab F, van Kerrebroeck P, Robinson D (2007) Patient-perceived outcomes in the treatment of stress urinary incontinence: focus on urethral injection therapy. Int Urogynecol J Pelvic Floor Dysfunct 18:199–205

    PubMed  Google Scholar 

  8. Corcos J, Collet JP, Shapiro S, Herschorn S, Radomski SB, Schick E, Gajewski JB, Benedetti A, MacRamallah E, Hyams B (2005) Multicenter randomized clinical trial comparing surgery and collagen injections for treatment of female stress urinary incontinence. Urology 65:898–904

    Article  PubMed  CAS  Google Scholar 

  9. Maher CF, O’Reilly BA, Dwyer PL, Carey MP, Cornish A, Schluter P (2005) Pubovaginal sling versus transurethral Macroplastique for stress urinary incontinence and intrinsic sphincter deficiency: a prospective randomised controlled trial. Br J Obstet Gynaecol 112:797–801

    Google Scholar 

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Authors and Affiliations

  1. Urogynecology and Reconstructive Pelvic Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Room HH333, Stanford, CA, 94305, USA

    Eric R. Sokol

  2. Urogynecology and Reconstructive Pelvic Surgery, Cleveland Clinic Florida, Weston, FL, USA

    Vivian C. Aguilar

  3. Division of Urogynecology and Reconstructive Pelvic Surgery, Warren Alpert Medical School of Brown University, Providence, RI, USA

    Vivian W. Sung & Deborah L. Myers

Authors
  1. Eric R. Sokol
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  2. Vivian C. Aguilar
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  3. Vivian W. Sung
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  4. Deborah L. Myers
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Correspondence to Eric R. Sokol.

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Sokol, E.R., Aguilar, V.C., Sung, V.W. et al. Combined trans- and periurethral injections of bulking agents for the treatment of intrinsic sphincter deficiency. Int Urogynecol J 19, 643–647 (2008). https://doi.org/10.1007/s00192-007-0493-7

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  • DOI: https://doi.org/10.1007/s00192-007-0493-7

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