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Regulation of antigen uptake, migration, and lifespan of dendritic cell by Toll-like receptors

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Abstract

Dendritic cells (DCs) sense the presence of pathogens through germline-encoded pattern recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms and endogenous stimuli. Toll-like receptors (TLRs) are the best characterized PRRs. TLR activation has a profound effect on a number of DC activities, including endocytosis, cytoskeleton rearrangement, migration, antigen processing and presentation, survival, and death. The goal of TLR-induced DC reprogramming is to promote the appropriate activation and differentiation of lymphocytes bearing clonally distributed antigen-specific receptors. In this review, we will focus on the functional consequences of TLR engagement for conventional DCs.

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Acknowledgments

This work was supported by grants from the European Union FP6 Program (DC-THERA: LSHG-CT-2004-512074 contract), the European Union FP7 Program (TOLERAGE: HEALTH-F4-2008-202156 and ENCITE: HEALTH-F4-2008-201842 contracts), the Associazione Italiana per la Ricerca sul Cancro (AIRC) and the Italian Ministry of Education and Research (COFIN).

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The authors declare no conflicting financial interest.

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  1. Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126, Milan, Italy

    Ivan Zanoni & Francesca Granucci

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  1. Ivan Zanoni
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  2. Francesca Granucci
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Correspondence to Francesca Granucci.

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Zanoni, I., Granucci, F. Regulation of antigen uptake, migration, and lifespan of dendritic cell by Toll-like receptors. J Mol Med 88, 873–880 (2010). https://doi.org/10.1007/s00109-010-0638-x

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  • DOI: https://doi.org/10.1007/s00109-010-0638-x

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