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Safety of acid-suppressing drugs

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Abstract

There is an extensive literature on the adverse effects of drugs that inhibit gastric acid secretion. This study presents a critical examination of interactions between antisecretory drugs and other compounds, the frequency of serious adverse effects relating to various body systems, the safety of antisecretory drugs in pregnancy, and longer-term safety data from postmarketing surveillance studies. While interactions with some other drugs, alcohol, and certain carcinogens are of potential concern, in practice clinically significant reactions appear to be rare if they occur at all. A small number of major side-effects have been documented, but they occur rarely, and postmarketing surveillance has not detected other longer-term sequelae. Safety of these drugs in pregnancy is not established, as data are so few. It is concluded that antisecretory agents, by comparison with most other classes of drugs, are remarkably well tolerated.

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Authors and Affiliations

  1. Department of Medicine, Heidelberg Repatriation Hospital, Melbourne, Australia

    Richard A. Smallwood MD, Roger G. Berlin MD, Neal Castagnoli PhD, Henk P. M. Festen MD, Christopher J. Hawkey MD, S. K. Lam MD, Michael J. S. Langman MD, Per Lundborg PhD & Andrew Parkinson PhD

  2. Merck, Sharp and Dohme Research Laboratories, West Point, Pennsylvania, USA

    Richard A. Smallwood MD, Roger G. Berlin MD, Neal Castagnoli PhD, Henk P. M. Festen MD, Christopher J. Hawkey MD, S. K. Lam MD, Michael J. S. Langman MD, Per Lundborg PhD & Andrew Parkinson PhD

  3. Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA

    Richard A. Smallwood MD, Roger G. Berlin MD, Neal Castagnoli PhD, Henk P. M. Festen MD, Christopher J. Hawkey MD, S. K. Lam MD, Michael J. S. Langman MD, Per Lundborg PhD & Andrew Parkinson PhD

  4. Department of Medicine, University of Connecticut, Connecticut, USA

    Richard A. Smallwood MD, Roger G. Berlin MD, Neal Castagnoli PhD, Henk P. M. Festen MD, Christopher J. Hawkey MD, S. K. Lam MD, Michael J. S. Langman MD, Per Lundborg PhD & Andrew Parkinson PhD

  5. Department of Medicine, University Hospital, Queens Medical Centre, Nottingham, UK

    Richard A. Smallwood MD, Roger G. Berlin MD, Neal Castagnoli PhD, Henk P. M. Festen MD, Christopher J. Hawkey MD, S. K. Lam MD, Michael J. S. Langman MD, Per Lundborg PhD & Andrew Parkinson PhD

  6. Department of Medicine, University of Hong Kong, Hong Kong

    Richard A. Smallwood MD, Roger G. Berlin MD, Neal Castagnoli PhD, Henk P. M. Festen MD, Christopher J. Hawkey MD, S. K. Lam MD, Michael J. S. Langman MD, Per Lundborg PhD & Andrew Parkinson PhD

  7. University Departmetn of Therapeutics, Nottingham, UK

    Richard A. Smallwood MD, Roger G. Berlin MD, Neal Castagnoli PhD, Henk P. M. Festen MD, Christopher J. Hawkey MD, S. K. Lam MD, Michael J. S. Langman MD, Per Lundborg PhD & Andrew Parkinson PhD

  8. Astra Hässle AB, Mölndal, Sweden

    Richard A. Smallwood MD, Roger G. Berlin MD, Neal Castagnoli PhD, Henk P. M. Festen MD, Christopher J. Hawkey MD, S. K. Lam MD, Michael J. S. Langman MD, Per Lundborg PhD & Andrew Parkinson PhD

  9. Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA

    Richard A. Smallwood MD, Roger G. Berlin MD, Neal Castagnoli PhD, Henk P. M. Festen MD, Christopher J. Hawkey MD, S. K. Lam MD, Michael J. S. Langman MD, Per Lundborg PhD & Andrew Parkinson PhD

Authors
  1. Richard A. Smallwood MD
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  2. Roger G. Berlin MD
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  3. Neal Castagnoli PhD
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  4. Henk P. M. Festen MD
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  5. Christopher J. Hawkey MD
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  6. S. K. Lam MD
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  7. Michael J. S. Langman MD
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  8. Per Lundborg PhD
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  9. Andrew Parkinson PhD
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Smallwood, R.A., Berlin, R.G., Castagnoli, N. et al. Safety of acid-suppressing drugs. Digest Dis Sci 40 (Suppl 2), 63S–80S (1995). https://doi.org/10.1007/BF02214872

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  • DOI: https://doi.org/10.1007/BF02214872

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