Skip to main content
SpringerLink
Log in

Biological effects of shock waves

  • Free Paper
  • Published:
World Journal of Urology Aims and scope Submit manuscript

Summary

Extracorporeal shock wave lithotripsy has become established worldwide as the method of choice for the treatment of nephrolithiasis and ureterolithiasis over the last 10 years. Although initial studies showed no damaging effects of the shock waves on organs and tissues, numerous recent reports have presented evidence for severe acute effects and chronic complications after shock wave treatment. The pathophysiological effects on kidneys and the histopathological effects on organs or tissues in man and animal, and also the effects on cells in culture and tumors are sumarized. Suspended and immobilized cell cultures were used to characterize and quantify the efficacy of shock wave. Extended applications of shock waves and possible modifications to shock wave generators are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Abrahams C, Lipson SB, Ross LS (1988) The effects of shock wave lithotripsy (ESWL) on canine kidneys (abstract). J Urol 139:324

    Google Scholar 

  2. Arduan J, Garcia-Gamez A, Cebezas J, Morales Lopez A, Maestro Duran JL, Cabezas J, Carcelan F (1988) Renal (extra-intra) morphology before and after ESWL, evaluated by magnetic resonance imaging. Abstract 0-5, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988

  3. Baba S, Hata M, Nakanoma T, Tazaki H (1988) Long-term bioeffects of extracorporeal shock waves on rat kidneys. Abstract 90, 21st Congress of the International Societ of Urology, Buenos Aires, 9.–14. 10. 1988

  4. Baumgartner BR, Dickey KW, Ambrose SS, Walton KN, Nelson RC, Bernardino ME (1987) changes after extracorporeal shock wave lithotripsy: appearance on MR imaging. Radiology 163:531–534

    Google Scholar 

  5. Begun FP, Lawson RK (1989) Long term effects of electrohydraulic shock waves on renal function and blood pressure. Abstract, 07-2, 7th World Congress on Endourology and ESWL, Kyoto, 27–30. 11. 1989

  6. Begun FP Lawson RK, Kearns CM, Thieu TM (1989) Electrohydraulic shock wave induced renal injury. J Urol 142:155–159

    Google Scholar 

  7. Berens ME, Schostock C, Hart L, Barshira Z, McCullough DL (1988) Effect of cell cycle and temperature on the antiproliferative effects of acoustic shock waves (SW) against human tumor cells (abstract). J Urol 139:304

    Google Scholar 

  8. Bräuner Th, Brümmer F, Hülser DF (1988) Einwirkung von Stoßwellen auf tierische Zellkulturen. Licht-und elektronenmikroskopische Untersuchungen (abstract). Biomed Tech (Berlin) [Suppl 2]:35

    Google Scholar 

  9. Bräuner Th, Brümmer, F, Hülser DF (1989) Histopathology of shock wave treated tumor cell suspensions and multicell tumor spheroids. Ultrasound Med Biol 15:451–460

    Google Scholar 

  10. Brendel W, Delius M, Goetz A (1987) Effect of shock waves on the microvasculature. Prog Appl Microcirc 12:41–50

    Google Scholar 

  11. Brewer SL, Atala AA, Ackerman DM, Steinbock GS (1988) Shock wave lithotripsy damage in human cadaver kidneys. J Endourol 2:333–339

    Google Scholar 

  12. Brümmer F, Bräuner Th, Brenner J, Hülser DF (1988) Effects of lithotripter-generated shock waves on L 1210 mouse leukemia cells detected by flow cytometry (abstract). Eur J Cell Biol 46 (Suppl 2212

    Google Scholar 

  13. Brümmer F, Brenner J, Bräuner Th, Hülser DF (1989) Effect of shock waves on suspended and immobilized L1210 cells. Ultrasound Med Biol 15:229–239

    Google Scholar 

  14. Brümmer F, Nesper M, Schiess K, Suhr D, Brenner J, Bräuner Th, Hülser DF (1989) Shock wave efficacy measured with a bioassay (abstract). Eur J Cell Biol 48 [Suppl 26]9

    Google Scholar 

  15. Brümmer F, Nesper M, Schiess K, Suhr D, Brenner J, Hülser DF (1989) Characterisation of shock wave efficiency with cell cultures. Abstract P 13-5, 7th World Congress on Endourology and ESWL, Kyoto, 27–30. 11. 1989

  16. Brümmer F, Staudenraus J, Nesper M, Suhr D, Eisenmenger W, Hülser DF (1989) Biological effects and physical characterization of shock waves generated by an XL-1 experimental lithotripter. Proc Ultrasonics Int 89:1130–1135

    Google Scholar 

  17. Chaussy Ch, Schmied E, Jocham D, Fuchs G, Brendel W, Forssman B, Hepp W (1986) Extracorporeal shock wave lithotripsy. Karger, Basel

    Google Scholar 

  18. Chaussy ChG, Randazzo RF, Fuchs GJ (1986) The effects of extracorporeal shock waves on human renal carcinoma cells and normal human embryonic kidney cells (abstract). J Urol 139:320

    Google Scholar 

  19. Chaussy ChG, Randazzo RF, Fuchs GJ (1986) The effects of extracorporeal shock waves on FANFT bladder tumors in C3H/He mice (abstract). J Urol 139:289

    Google Scholar 

  20. Chinn SKB, Michaels EK, Fowler JE, Behnia R, Linde HW, Ray V (1988) Hemodynamic and adrenal response to shock wave energy (abstract). J Urol 139:324

    Google Scholar 

  21. Cole RS, Montgomery BSI (1989) The incidence of hypertension 29 months after renal ESWL. Abstract 07-3, 7th World Congress on Endourology and ESWL, Kyoto, 27.–30. 11. 1989

  22. Coleman AJ, Saunder JE, Crum LA, Dyson M (1987) Acoustic cavitation generated by an extracorporeal shockwave lithotripter. Ultrasound Med Biol 13:69–76

    Google Scholar 

  23. Das G, Brich B, Garden P, Wickham JEA (1988) The biological effects of shockwave lithotripsy. Abstract 0-17, 6th World Congress on Endourology and ESWL, Paris, 1.-3. 9. 1988

  24. Delius M, Enders G, Heine G, Stark J, Remberger K, Brendel W (1987) Biological effects of shock waves: lung hemorrhage by shock waves in dogs-pressure dependence. Ultrasound Med Biol 13:61–67

    Google Scholar 

  25. Delius M, Enders G, Xuan Z, Liebich HG, Brendel W (1988) Biolocial effects of shock waves: kidney damage by shock waves in dogs-dose dependence. Ultrasound Med Biol 14:117–122

    Google Scholar 

  26. Delius M, Weiss N, Gambihler S, Goetz A, Brendel W (1989) Tumor therapy with shock waves requires modified lithotripter shock waves. Naturwissenschaften 76:573–574

    Google Scholar 

  27. Di Cello V, Selli C, Fiorelli C, Nicita G, Carini M, Saltutti C, Fontanelli A, Rosi E, Doni A (1988) Study of fibrinolytic system changes following ESWL. Abstract 0-15, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988

  28. Drach GW (1988) Side effects of shock-wave lithotripsy—an overview. Abstract 92, 21st Congress of the International Society of Urology, Buenos Aires, 9.–14. 10. 1988

  29. Eisenberger F, Rassweiler J (1986) Extrakorporale Stoßwellenlithotripsie im Wandel. Akt Urol 17:229–233

    Google Scholar 

  30. Eisenberger F, Fuchs GJ, Gumpinger R, Miller K, Rassweiler J (1987) Urologische Steintherapie—ESWL und Endourologie. Thieme, Stuttgart

    Google Scholar 

  31. Eisenmenger W (1961) Eine elektromagnetische Impulsschallquelle zur Erzeugung von Druckstößen in Flüssigkeiten und Festkörpern. Proceedings of the 3rd International Congress on Acoustics, Stuttgart, 1959, 326–329

  32. Eisenmenger W (1962) Elektromagnetische Erzeugung von ebenen Druckstößen in Flüssigkeiten. Acustica 12:185–202

    Google Scholar 

  33. Eisenmenger W (1988) Methoden der Stoßwellenerzeugung und messung. Biomed Tech (Berlin) 33 (Suppl 2] 1–6

    Google Scholar 

  34. Ell C, Kerzel W, Heyder N, Rödl W, Langer H, Mischke U, Giedl J, Domschke W (1989) Tissue reactions under piezoelectric shockwave application for the fragmentation of biliary calculi. Gut 30:680–685

    Google Scholar 

  35. Fischer N, Müller HM, Gulhan A, Sohn M, Deutz FJ, Rubben H, Lutzeyer W (1988) Cavitation effects: possible cause of tissue injury during extracorporeal shock wave lithotripsy. J Endourol 2:215–220

    Google Scholar 

  36. Geldof AA, Voogt HJ de, Rao BR (1989) High energy shock waves do not affect either primary tumor growth or metastasis of prostate carcinoma, R 2237-MatLyLu. Urol Res 17:9–12

    Google Scholar 

  37. Grote R, Döhring W, Aeikens B (1986) Computertomographischer und sonographischer Nachweis von renalen und perirenalen Veränderungen nach einer extrakorporalen Stoßwellenlithotripsie. Fortschr Röntgenstr 144:434–439

    Google Scholar 

  38. Hahn EW, Riedlinger R, Mattern J, Ueberle W, Bak M, Peschke P, Lorenz A, Zuna I, Gerlach L, Volm M, Kaick G van, Lorenz WJ (1988) High energy pulsed ultrasound (HEPUS): cytotoxic effecs on rodent tumors. Biomed Tech (Berlin) 33 [Suppl 2]141–142

    Google Scholar 

  39. Haupt G, Haupt A, Donovan JM, Drach GW, Chaussy Ch (1989) Short-term changes of laboratory values after extracorporeal shock wave lithitropsy: a comparative study. J Urol 142:259–262

    Google Scholar 

  40. Holmes RP, Yeaman LD, Taylor RG, Lewis JC, McCullough DL (1988) Enhanced Adriamycin uptake by neutrophils exposed to shock waves (abstract). J Urol 139:304

    Google Scholar 

  41. Hülser DF, Brümmer F, Brenner J, Bräuner Th, Nesper M (1988) Zell-und Gewebsveränderungen durch eine Stoßwellenbehandlung. Biomed Tech (Berlin) 33 [Suppl 2]:7–10

    Google Scholar 

  42. Jaeger P, Deslarzes C, Ginalski JM (1988) Evidence by ureteral catheterization of subtile renal tubular dysfunction after ESWL. Abstract 0-8, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988

  43. Jaeger P, Redha F, Uhlschmid G, Hauri D (1988) Morphological changes in canine kidneys following extracorporeal shock wave treatment. J Endourol 2:205–213

    Google Scholar 

  44. Janssens J, Baert L, De Geest H, Ector H (1988) Extracorporeal shock wave lithotripsy and cardiac arrhytmias. Abstract 0-14. 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988

  45. Kaude JV, Williams CM, Millner MR, Scott KN, Finlayson B (1985) Renal morphology and function immediately after extracorporeal shock-wave lithotripsy. AJR 145:305–313

    Google Scholar 

  46. Kishimoto T, Yamamoto K, Sugimoto T, Yoshihara H, Maekawa M (1986) Side effects of extracorporeal shock-wave exposure in patients treated by extracorporeal shock-wave lithotripsy for upper urinary tract stone. Eur Urol 12:308–313

    Google Scholar 

  47. Knapp PM, Kulb TB, Lingeman JE, Newman DM, Mertz JHO, Mosbaugh PG, Steele RE (1988) Extracorporeal shock wave lithotripsy-induced perirenal hematomas. J Urol 139:700–703

    Google Scholar 

  48. Krongrad A, Saltzman B, Tannenbaum M, Droller MJ (1988) Enzymuria following extracorporeal shock wave lithotripsy (ESWL) (abstract). J Urol 139:324

    Google Scholar 

  49. Kurzweil SJ, Smith JE, Arsdalen K van (1988) Effects of extracorporeal shock waves on skeletal and renal growth in the infant rabbit (abstract). J Urol 139:325

    Google Scholar 

  50. Lingeman JE, Kulb TB (1987) Hypertension following extracorporeal shock wave lithitripsy (abstract). J Urol 137:142

    Google Scholar 

  51. Loening SA, Mardan AH, Holmes J, Lubaroff DM (1988) In vivo and in vitro effects of shock waves on dunning prostate tumors (abstract). J Urol 139:303

    Google Scholar 

  52. Loening SA, Mardan AH, Lubaroff DM (1988) In vivo pathological effects of high energy shock waves generated by an experimental extracorporeal shock wave lithotripter (abstract). J Urol 139:323

    Google Scholar 

  53. Marcellan R, Servio LI (1986) Evaluation of renal damage in extracorporeal lithotripsy by shock waves. Eur Urol 12:73–75

    Google Scholar 

  54. Mardan A, Loening S (1988) Pathological reactions in rats to highenergy shock waves: 1. Local tissue responses. Abstract 0-51, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988

  55. Mardan A, Loening S (1988) Pathological reactions in rats to highenergy shock waves: 2. Systemic responses. Abstract O-52, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988

  56. McCullough DL, Yeaman LD, Bo WJ, Assimos DG, Kroovand RL, Griffin AS, Furr EG (1988) Do extracorporeal shock waves affect fertility and fetal development? A study of shock wave effects on the rat ovary and fetus (abstract). J Urol 139:325

    Google Scholar 

  57. Morgan RT, Laudone VP, Heston WDW, Zeitz L, Fair WR (1988) Free radical production by high energy shock waves—comparison with ionizing irradiation. J Urol 139:186–189

    Google Scholar 

  58. Müller M (1987) Stoßwellenfokussierung in Wasser. Ph. D thesis, RWTH Aachen, FRG

    Google Scholar 

  59. Müller-Klieser W (1987) Multicellular spheroids. A review on cellular aggregates in cancer research. J Cancer Res Clin Oncol 113:101–122

    Google Scholar 

  60. Newman DM, Lingeman JE, Woods JR, Toth PD (1989) Blood pressure changes following extracorporeal shock wave lithotripsy and other forms of treatment for urolithiasis. Abstract 07-4, 7th World Congress on Endourology and ESWL, Kyoto, 27.–30. 11. 1989

  61. Newman R, Hackett R, Senior D, Brock B, Feldman J, Sosnowski J, Finlayson B (1987) Pathologic effects of ESWL on canine renal tissue. Urology 29:194–200

    Google Scholar 

  62. Oosterhof GON, Smits GAHJ, Ruyter JE de, Morselaar RJA, Schalken JA, Debruyne FMM (1989) The in vitro effect of electromagnetically generated shock waves (lithostar) on the Dunning R3327 PAT-2 rat prostatic cancer cell-line. Urol Res 17:13–19

    Google Scholar 

  63. Peschke P, Hahn EW, Lorenz WJ, Debus J, Zabel HJ, Ifflaender H, Lorenz A, Kaick G van, Pfeiler M (1989) Pulsed high energy ultrasound shock-waves (PHEUS): biological effects on the Dunning prostate rat tumor. Abstract P 13-7, 7th World Congress on Endourology and ESWL, Kyoto, 27.–30. 11. 1989

  64. Ponchon T, Barkun AN, Berger F, Ayela P, Margonari J, Capron F (1989) Experimental tissue lesions related to extracorporeal lithotripsy of gallbladder. Surg Gynecol Obstet 169:435–441

    Google Scholar 

  65. Randazzo RR, Chaussy CG, Fuchs GJ, Bhuta SM, Lovrekovich H., de Kernion JB (1988) The in vitro and in vivo effects of extracorporeal shock waves on malignant cells. Urol Res 16:419–426

    Google Scholar 

  66. Rassweiler J, Westhauser A, Bub P, Eisenberger F 81988) Secondgeneration lithitropters: a comparative study. J Endourol 2:193–204

  67. Recker F, Rübben H, Hofstädter F, Bex A (1988) Ultramorphological acute and long term lesions of ESWL in rat kidney. Abstract 0-54, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988

  68. Recker F, Ruebben H, Neuerburg J, Bex A, Deutz FJ, Hofstaedter F (1990) Magnetic resonance imaging of acute and long-term alterations following extracorporeal shock wave lithotripsy in rats. Urol Int 4:28–33

    Google Scholar 

  69. Riedlinger R, Ueberle F, Zanger U (1988) HEPUS (high energy pulsed ultrasound): apparatus and physical aspects of tumor-insonification. Biomed Tech (Berlin) 33 [Suppl 2]:139–140

    Google Scholar 

  70. Riedlinger RE, Brümmer F, Hülser DF (1989) Pulsed high-power-sonication of concrements, cancer cells and rodent-tumors in vivo. Proc Ultrasonics Int 89:305–312

    Google Scholar 

  71. Rubin JI, Arger PH, Pollack HM, Banner MP, Coleman BG, Mintz MC, Van Arsdalen KN (1987) Kidney changes after extracorporeal shock wave lithotripsy: CT evaluation. Radiology 162:21–24

    Google Scholar 

  72. Russo P, Stephenson RA, Mies C, Huryk R, Heston WDW, Melamed MR, Fair WR (1986) High energy shock waves suppress tumor growth in vitro and in vivo. J Urol 135:626–628

    Google Scholar 

  73. Russo P, Mies C, Huryk R, Heston WDW, Fair WR (1987) Histopathologic and ultrastructural correlates of tumor growth suppression by high energy shock waves. J Urol 137:338–341

    Google Scholar 

  74. Saitoh T, Ioritani N, Kuwahara M, Shirai S, Kambe K, Taguchi K, Orikasa S (1989) Chronic changes of renal tissue exposed to focused shock waves. Abstract P11-15, 7th World Congress on Endourology and ESWL, Kyoto, 27.–30. 11. 1989

  75. Schneider HT, Ell C (1989) Schmerzreaktion: Systemvergleich. Oral presentation, Meeting on Medical Technology, Berlin, 6.–11. 11. 1989

  76. Schulze H, Falkenberg F, Mondorf AW, Engelmann U, Senge Th (1988) Enhanced excretion of kidney-derived antigens in the urine of patients after ESWL treatment (abstract). J Urol 139:323

    Google Scholar 

  77. Steele R (1988) Blood pressure changes following ESWL. Abstract 0-12, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988

  78. Steinmann J, Wilbert DM, Strohmeier WL, Flüchter SH, Bichler KH (1988) Glomerular and tubular changes after extracorporeal shock wave lithotripsy measured by urinary proteins. Abstract 0-9, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9. 1988

  79. Stephenson TJ, Johnson AG, Ross B (1989) Short-term effects of extracorporeal shock wave lithotripsy on the human gallbladder. J Pathol 158:239–246

    Google Scholar 

  80. Sutherland RM (1988) Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 240:177–184

    Google Scholar 

  81. Tashiro K, Mochizuki A, Machida T (1988) Renal tissues damaged by piezoelectric shock waves. Abstract 0-55, 6th World Congress on endourology and ESWL, Paris, 1.–3. 9., 1988

  82. Thomas R, Sloane B, Roberts J (1988) Long-term effect of extracorporeal shock wave lithotripsy on renal function. Abstract 0-11, 6th World Congress on Endourology and ESWL, Paris, 1.–3. 9., 1988

  83. Tiselius HG, Eriksson I, Sandvall K (1989) Is blood pressure affected by ESWL-treatment? Abstract 05-5, 7th World Congress on Endourology and ESWL, Kyoto, 27–30. 11. 1989

  84. Van Dongen JW, Van Steenbrugge GJ, Romijn JC, Schröder FH (1989) The cytocidal effect of high energy shock waves on human prostatic tumour cell lines. Eur J Cancer Clin Oncol 25:1173–1179

    Google Scholar 

  85. Weiss N (1989) Verstärkung der Zytostatika-Wirkung durch Stoßwellen. Oral presentation, Körber-Stiftung Symposiuml “Stoßwellen-Anwendungen in der Medizin”, München, 16. 2. 1989

  86. Williams AR, Delius M, Miller DL, Schwarze W (1989) Investigation of cavitation in flowing media by lithotripter shock waves both in vitro and in vivo. Ultrasound Med Biol 15:53–60

    Google Scholar 

  87. Williams CM, Kaude JV, Newman RC, Peterson JC, Thomas WC (1988) Extracorporeal shock-wave lithotripsy: long-term complications. AJR 150:311–315

    Google Scholar 

  88. Wilmer A, Gambihler S, Delius M, Brendel W (1989) In vitro cytotoxic activity of lithotripter shock waves combined with Adriamycin or with cisplatin on L1210 mouse leukemia cells. J Cancer Res Clin Oncol 115:229–234

    Google Scholar 

  89. Yang C, Heston WDW, Gulati S, Fair WR (1988) The effect of high energy shock waves (HESW) on human bone marrow. Urol Res 16:427–429

    Google Scholar 

  90. Yeaman LD, McCullough DL, Jerome CP (1988) Effects of extracorporeal shock waves on immature bone growth of the rat (abstract). J Urol 139:324

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung Biophysik, Biologisches Institut, Universität Stuttgart, Pfaffenwaldring 57, W-7000, Stuttgart 80, Federal Republic of Germany

    F. Brümmer, Th. Bräuner & D. F. Hülser

Authors
  1. F. Brümmer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Th. Bräuner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. F. Hülser
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Dedicated to Prof. Dr. Wolfgang Eisenmenger on the occasion of his 60th birthday

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brümmer, F., Bräuner, T. & Hülser, D.F. Biological effects of shock waves. World J Urol 8, 224–232 (1990). https://doi.org/10.1007/BF01580025

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01580025

Keywords

Search

Navigation