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Delta crystallins and their nucleic acids

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Summary

δ-Crystallin is a major structural protein of avian and reptilian lenses that is absent from the lenses of fish, amphibia and mammals. It appears to be a tetrameric protein with a native molecular weight near 200 000 (200K) and polypeptide molecular weights near (50K and 48K) (see Note added in proof). The δ-crystallin polypeptides are extremely similar, associate in various combinations of four and are held together by hydrophobic interactions. Although principally cytoplasmic, δ-crystallin may associate with the cell membranes. δ-Crystallin differs from other lens crystallins in its α-helical content, native and subunit molecular weights, antigenicity, low wavelength of maximum fluorescence emission (315 nm) after excitation at 280 nm and amino acid composition (high in leucine; low in aromatic residues en no cysteine). Analyses of peptides, native and subunit molecular weights, and circular dichroism spectra indicate that the primary, secondary, tertiary and subunit structures of δ-crystallin have been generally conserved during evolution. There are at least two tandemly arranged δ-crystallin genes containing 13–15 introns in the chicken; a similar structure exists for a cloned δ-crystallin gene in the duck. Experiments with chicken show that δ-crystallin synthesis occurs principally in the embryo, especially during lens fiber cell differentiation. δ-Crystallin synthesis also takes place during lens fiber cell differentiation in culture. There is evidence for both transcriptional and post-transcriptional regulation of δ-crystallin synthesis. Current studies on the crystallographic and primary structures of δ-crystallin, on the structure, evolution and expression of the δ-crystallin genes, and on the translation of δ-crystallin mRNAs make this specialized lens protein an active area of investigation.

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References

  1. Clayton, R. M., 1974. The Eye (Davson, H. and Graham, L. T., eds.), Vol. 5, pp. 399–494, Academic Press, Inc., New York, London.

  2. Harding, J. J. and Dilley, K. J., 1976. Exp. Eye. Res. 22: 1–73.

    Google Scholar 

  3. Bloemendal, H., 1977. Science 197: 127–138.

    Google Scholar 

  4. Bloemendal, H., 1981. Molecular and Cellular Biology of the Eye Lens (Bloemendal, H., ed.), pp. 1—47, John Wiley and Sons, New York.

  5. Croft, L. R., 1972. Biochem. J. 128: 961–970.

    Google Scholar 

  6. Driessen, H. P. C., Herbrink, P., Bloemendal, H. and de Jong, W. W., 1980. Exp. Eye Res. 31: 213–216.

    Google Scholar 

  7. Driessen, H. P. C., Herbrink, P., Bloemendal, H. and de Jong, W. W., 1981. Eur. J. Biochem. 121: 83–91.

    Google Scholar 

  8. Inana, G., Shinohara, T., Maizel, J. V. Jr. and Piatigorsky, J., 1982. J. Biol. Chem. 257: 9064–9071.

    Google Scholar 

  9. Stauffer, J., Rothschild, C., Wandel, T. and Spector, A., 1974. Invest. Ophthalmol. 13: 135–146.

    Google Scholar 

  10. Hoenders, H. J. and Bloemendal, H., 1981. Molecular and Cellular Biology of the Eye Lens (Bloemendal, H., ed.), pp. 279–326, John Wiley and Sons, New York.

  11. Harding, J. J., 1981. Molecular and Cellular Biology of the Eye Lens (Bloemendal, H., ed.), pp. 327–365, John Wiley and Sons, New York.

  12. Zigler, J. S., Jr. and Goosey, J., 1981. TIBS 6: 133–136.

    Google Scholar 

  13. Papaconstantinou, J., 1967. Science 156: 338–346.

    Google Scholar 

  14. Zwaan, J. and Ikeda, A., 1968. Exp. Eye Res. 7: 301–311.

    Google Scholar 

  15. Clayton, R. M., 1970. Current Topics of Developmental Biology (Moscona, A. A. and Monroy, A., eds.), Vol. 5, pp. 115–180, Academic Press, Inc., New York.

  16. McAvoy, J. W., 1980. Differentiation 17: 137–149.

    Google Scholar 

  17. Piatigorsky, J., 1981. Differentiation 19: 134–153.

    Google Scholar 

  18. McDevitt, D. S. and Brahma, S. K., 1982. Cell Biology of the Eye (McDevitt, D. S., ed.), pp. 143–191, Academic Press, Inc., New York.

  19. Williams, L. A. and Piatigorsky, J., 1979. Eur. J. Biochem. 100: 349–357.

    Google Scholar 

  20. Rabaey, M., 1962. Exp. Eye Res. 1: 310–316.

    Google Scholar 

  21. Maisel, H. and Langman, J., 1961. J. Embryol. exp. Morph. 9: 191–201.

    Google Scholar 

  22. Maisel, H. and Langman, J., 1961. Anat. Rec. 140: 183–193.

    Google Scholar 

  23. Clayton, R. M. and Trumah, D. E. S., 1967. Nature 214: 1201–1204.

    Google Scholar 

  24. Zwaan, J. and Ikeda, A., 1965. Eye Structure II. Symp (Rohen, J. W., ed.), pp. 419–429 Schattauer-Verlag, Stuttgart.

  25. Piatigorsky, J., Beebe, D. C., Zelenka, P., Milstone, L. M. and Shinohara, T., 1976. Biology of the Epithelial Lens Cells in Relation to Development, Aging and Cataract (Courtois, Y. and Regnault, F., eds.), INSERM 60: 85–104.

  26. Okada, T. S., 1980. Current Topics in Developmental Biology (Moscona, A. and Monroy, A., eds.), Vol. 16, pp. 349–380, Academic Press, Inc., New York, London.

  27. Clayton, R. M., 1982. Differentiation in vitro: British Society for Cell Biology Symposium 4 (Yeoman, M. M. and Truman, D. E. S.), pp. 83–120, University Press, Cambridge, Great Britain.

  28. Yamada, T., 1982. Cell Biology of the Eye (McDevitt, D. S., ed.), pp. 193–242, Academic Press, Inc., New York.

  29. Piatigorsky, J., 1980. Current Topics in Eye Research (Davson, H. and Zadunaisky, J. A., eds.), Vol. 3, pp. 1–39, Academic Press, Inc., New York, London.

  30. Piatigorsky, J., Shinohara, T., Bhat, S. P., Reszelbach, R., Jones, R. E. and Sullivan, M. A., 1980. Ann. N.Y. Acad. Sci. 339: 265–279.

    Google Scholar 

  31. de Jong, W. W., 1981. Molecular and Cellular Biology of the Eye Lens (Bloemendal, H., ed.), pp. 221–278, John Wiley and Sons, New York.

  32. Genis-Galvez, J. M., Maisel, H. and Castro, J., 1968. Exp. Eye Res. 7: 593–602.

    Google Scholar 

  33. Truman, D. E. S., 1968. Exp. Eye Res. 7: 358–368.

    Google Scholar 

  34. Rabaey, M., Lagasse, A. and de Mets, M., 1969. Acta Zool. Pathol. Antverpiensia 48: 63–71.

    Google Scholar 

  35. Watanabe, H. and Kawakami, I., 1973. Exp. Eye Res. 17: 205–207.

    Google Scholar 

  36. Zigler, J. S., Jr. and Sidbury, J. B., Jr., 1976. Comp. Biochem. Physiol. 55B: 19–24.

    Google Scholar 

  37. Beebe, D. C. and Piatigorsky, J., 1976. Exp. Eye Res. 22: 237–249.

    Google Scholar 

  38. Pal, J. K., Nerurkar, A. R. and Goel, S. C., 1980. Exp. Eye Res. 30, 739–746.

    Google Scholar 

  39. Thomson, I., Wilkinson, C. E., Burns, A. T. H., Truman, D. E. S. and Clayton, R. M., 1978. Exp. Eye Res. 26: 351–362.

    Google Scholar 

  40. Truman, D. E. S., Brown, A. G. and Rao, K. V., 1971. Exp. Eye Res. 12: 304–310.

    Google Scholar 

  41. Craig, S. P. and Piatigorsky, J., 1973. Biochim. Biophys. Acta 299: 642–653.

    Google Scholar 

  42. Piatigorsky, J., Zelenka, P. and Simpson, R. T., 1974. Exp. Eye Res. 18: 435–446.

    Google Scholar 

  43. Williams, L. A., Piatigorsky, J. and Horwitz, J., 1982. Biochim. Biophys. Acta 708: 49–56.

    Google Scholar 

  44. Zwaan, J., 1968. Exp. Eye Res. 7: 461–472.

    Google Scholar 

  45. Hoenders, H. J., 1965. Ph.D. Thesis, University of Amsterdam, Amsterdam, The Netherlands.

    Google Scholar 

  46. Piatigorsky, J., Webster, H. de F. and Craig, S. P., 1972. Develop. Biol. 27: 176–189.

    Google Scholar 

  47. de Jong, W. W., Stapel, S. O. and Zweers, A., 1981. Comp. Biochem. Physiol. 69B: 593–598.

    Google Scholar 

  48. Ostrer, H. and Piatigorsky, J., 1980. Exp. Eye Res. 30: 679–689.

    Google Scholar 

  49. Piatigorsky, J., Horwitz, J. and Simpson, R. T., 1977. Biochim. Biophys. Acta 490: 279–289.

    Google Scholar 

  50. Reszelbach, R., Shinohara, T. and Piatigorsky, J., 1977. Exp. Eye Res. 25: 583–593.

    Google Scholar 

  51. Piatigorsky, J., 1981. Biochemistry 20: 6427–6431.

    Google Scholar 

  52. Clayton, R. M., 1969. Exp. Eye Res. 8: 326–339.

    Google Scholar 

  53. Truman, D. E. S., Brown, A. G. and Campbell, J. C., 1972. Exp. Eye Res. 13: 58–69.

    Google Scholar 

  54. Burns, A. T. H., 1975. Ph.D. Thesis, Univ. of Edinburgh, Edinburgh, Scotland.

    Google Scholar 

  55. Gerding, J. J. T., Koppers, A., Hagel, P. and Bloemendal, H., 1971. Biochim. Biophys. Acta 243: 374–379.

    Article  CAS  PubMed  Google Scholar 

  56. Piatigorsky, J., 1976. J. Biol. Chem. 251: 4416–4420.

    Google Scholar 

  57. Zelenka, P. and Piatigorsky, J., 1976. Exp. Eye Res. 22: 115–124.

    Google Scholar 

  58. Shinohara, T., Reszelbach, R. and Piatigorsky, J., 1980. Exp. Eye Res. 30: 361–370.

    Google Scholar 

  59. Zwaan, J., 1966. Exp. Eye Res. 5: 267–275.

    Google Scholar 

  60. Kuck, J. F. R., Jr., East, E. J. and Yu, N.-T., 1976. Exp. Eye Res. 23: 9–14.

    Google Scholar 

  61. Kuck, J. F. R., Yu, N.-T. and Askren, C. C., 1982. Exp. Eye Res. 34: 23–37.

    Google Scholar 

  62. Genis-Galvez, J. M., Castro, J. M. and Battaner, E., 1968. Nature 217: 652–654.

    Google Scholar 

  63. Askren, C. C., Yu, N.-T. and Kuck, J. F. R., Jr., 1979. Exp. Eye Res. 29: 647–654.

    Google Scholar 

  64. Lerman, S., 1980. Radiant Energy and the Eye, Macmillan Publishing Co., Inc., New York.

    Google Scholar 

  65. Harmsen, B. J. M., van Dam, A. F. and van Os, G. A. J., 1966. Biochim. Biophys. Acta 126: 540–550.

    Google Scholar 

  66. Li, L.-K. and Spector, A., 1967. J. Biol. Chem. 242: 3234–3244.

    Google Scholar 

  67. ones, H. A. and Lerman, S., 1971. Can. J. Biochem. 49: 426–430.

    Google Scholar 

  68. Li, L.-K. and Spector, A., 1974. Exp. Eye Res. 19: 49–57.

    Google Scholar 

  69. Yu, N.-T. and East, E., 1975. J. Biol. Chem. 250: 2196–2202.

    Google Scholar 

  70. Horwitz, J., 1976. Exp. Eye Res. 23: 471–481.

    Google Scholar 

  71. Zigler, J. S., Jr., Horwitz, J. and Kinoshita, J. H., 1980. Exp. Eye Res. 31: 41–45.

    Google Scholar 

  72. Zigler, J. S., Jr., Horwitz, J. and Kinoshita, J. H., 1981. Exp. Eye Res. 32: 21–30.

    Google Scholar 

  73. Yu, N.-T., East, E. J., Chang, R. C. C. and Kuck, J. F. R., Jr., 1977. Exp. Eye Res. 24: 321–334.

    Google Scholar 

  74. Horwitz, J. and Piatigorsky, J., 1980. Biochim. Biophys. Acta. 642: 21–29.

    Google Scholar 

  75. Siezen, R. J. and Shaw, D. C., 1982. Biochim. Biophys. Acta 704: 304–320.

    Google Scholar 

  76. Greenfield, N. and Fasman, G. D., 1969. Biochemistry 8: 4108–4116.

    Google Scholar 

  77. Strictland, E. H., 1974. CRC Reviews in Biochemistry (Fasman, G. ed.), Vol. 11, pp. 113–175, CRC Press, Cleveland.

  78. Longworth, J. W., 1971. Excited States of Proteins and Nucleic Acids (Steiner, R. F. and Weinryb, L, eds.), pp. 319–474, Plenum Press, New York.

  79. Burstein, E. A., Vedenkina, N. S. and Ivkova, M. N., 1973. Photochem. Photobiol. 10: 263–279.

    Google Scholar 

  80. Narebor, E., Slingsby, C., Lindley, P. F. and Blundell, T. L., 1980. J. Mol. Biol. 143: 223–225.

    Google Scholar 

  81. Bours, J. and van Doorenmaalen, W. J., 1970. Science Tools 17: 36–38.

    Google Scholar 

  82. Bours, J., 1974. Doc. Ophthalmol. 37: 1–46.

    Google Scholar 

  83. Brahma, S. K. and van der Starre, H., 1976. Exp. Cell Res. 97: 175–183.

    Google Scholar 

  84. Mishima, N. and Ikeda, A., 1981. Exp. Eye Res. 32: 363–368.

    Google Scholar 

  85. Bouts, J., 1976. Isoelectric Focusing (Catsimpoolas, N., ed.), pp. 209–228, Academic Press, Inc., San Francisco, London.

  86. Piatigorsky, J., 1978. Exp. Eye Res. 27: 227–237.

    Google Scholar 

  87. illiams, L. A. and Piatigorsky, J., 1979. Biochemistry 18: 1438–1442.

    Google Scholar 

  88. Brahma, S. K. and van der Starre, H., 1981. Exp. Eye Res. 33: 515–524.

    Google Scholar 

  89. Maisel, H., Lieska, N. and Alcala, J., 1975. Ophthalmol. Res. 7: 416–419.

    Google Scholar 

  90. Alcala, J., Maisel, H. and Lieska, N., 1977. Exp. Cell Res. 109: 63–69.

    Google Scholar 

  91. Zwaan, J., 1968. J. Cell. Physiol. 72 (Suppl. 1): 47–72.

    Google Scholar 

  92. Zelenka, P., Reszelbach, R. and Piatigorsky, J., 1979. Biochim. Biophys. Acta 556: 447–456.

    Google Scholar 

  93. Alcala, J., Maisel, H., Katar, M. and Ellis, M., 1982. Exp. Eye Res. 35: 379–383.

    Google Scholar 

  94. Ramaekers, F. C. S., Selten-Versteegen, A.-M. E. and Bloemendal, H., 1980. Biochim. Biophys. Acta 596: 57–63.

    Google Scholar 

  95. Inana, G., Piatigorsky, J., Norman, B., Slingsby, C. and Blundell, T., 1983. Nature 302: 310–315.

    Google Scholar 

  96. Benedetti, E. L., Dunia, I., Ramaekers, F. C. S. and Kibbelaar, M. A., 1981. Molecular and Cellular Biology of the Eye Lens (Bloemendal, H., ed.), pp. 137–188, John Wiley and Sons, New York.

  97. Zelenka, P. and Piatigorsky, J., 1974. Proc. Natl. Acad. Sci. U.S.A. 71: 1896–1900.

    Google Scholar 

  98. Thomson, I., Wilkinson, C. E., Jackson, J. F., de Pomerai, D. I., Clayton, R. M., Truman, D. E. S. and Williamson, R., 1978. Develop. Biol. 65: 372–382.

    Google Scholar 

  99. Lavers, G. C., 1976. Mol. Biol. Rep. 3: 65–71.

    Google Scholar 

  100. Jackson, J. F., Clayton, R. M., Williamson, R., Thomson, I., Truman, D. E. S. and de Pomerai, D. I., 1978. Develop. Biol. 65: 383–395.

    Google Scholar 

  101. Bhat, S. P. and Piatigorsky, J., 1979. Proc. Natl. Acad. Sci. U.S.A. 76: 3299–3303.

    Google Scholar 

  102. Shinohara, T. and Piatigorsky, J., 1980. Exp. Eye Res. 30: 351–360.

    Google Scholar 

  103. Bower, D. J., Errington, L. H., Wainwright, N. R., Sime, C., Morris, S. and Clayton, R. M., 1981. Biochem. J. 201: 339–344.

    Google Scholar 

  104. Williamson, R., Clayton, R. and Truman, D. E. S., 1972. Biochem. Biophys. Res. Commun. 46: 1936–1943.

    Google Scholar 

  105. Lavers, G. C., 1979. Exp. Eye Res. 28: 299–309.

    Google Scholar 

  106. Lavers, G. C., 1977. Mol. Biol. Rep. 3: 275–281.

    Google Scholar 

  107. Banerjee, A. K., 1980. Microbiol. Rev. 44: 175–205.

    Google Scholar 

  108. Lavers, G. C., 1978. Mol. Biel. Rep. 4: 233–236.

    Google Scholar 

  109. Asselbergs, F. A. M., Peters, W. H. M., van Venrooij, W. J. and Bloemendal, H., 1978. Biochim. Biophys. Acta 520: 577–587.

    Google Scholar 

  110. Yasuda, K., Kondoh, H., Okada, T. S., Nakajima, N. and Shimura, Y., 1982. Nucleic Acids Res. 10: 2879–2891.

    Google Scholar 

  111. Nickerson, J. M. and Piatigorsky, J., 1982. FEBS Lett. 144: 289–292.

    Google Scholar 

  112. Garnier, J., Osguthorpe, D. J. and Robson, B., 1978. J. Mol. Biol. 120: 97–120.

    Google Scholar 

  113. Maizel, J. V., Jr., and Lenk, R. P., 1981. Proc. Natl. Acad. Sci. U.S.A. 78: 7665–7669.

    Google Scholar 

  114. an der Ouderaa, F. J., de Jong, W. W. and Bloemendal, H., 1973. Eur. J. Biochem. 39: 207–222.

    Google Scholar 

  115. van der Ouderaa, F. J., de Jong, W. W., Hilderink, A. and Bloemendal, H., 1974. Eur. J. Biochem. 49: 157–168.

    Google Scholar 

  116. Dayhoff, M. O., Hunt, L. T., Barker, W. C., Orcutt, D. C., Yeh, L.-S., Chen, H. R., George, D. G., Blomquist, M. C., Fredrickson, J. A. and Johnson, G. C., 1981. Protein Sequence Database, National Biomedical Research Foundation, Washington DC.

    Google Scholar 

  117. Nickerson, J. M. and Piatigorsky, J., 1982. J. Cell Biol. 95: 215a.

  118. Okayama, H. and Berg, P., 1982. Mol. Cell. Biol. 2: 161–170.

    Google Scholar 

  119. Proudfoot, N. J. and Brownlee, G. G., 1976. Nature 263: 211–214.

    Google Scholar 

  120. Moormann, R. J. M., den Dunnen, J. T., Bloemendal, H. and Schoenmakers, J. G. G., 1982. Proc. Natl. Acad. Sci. U.S.A. 79: 6876–6880.

    Google Scholar 

  121. Moormann, R. J. M., van der Velden, H. M. W., Dodement, H. J., Andreoli, P. M., Bloemendal, H. and Schoenmakers, J. G. G., 1981. Nucleic Acids Res. 9: 4813–4822.

    Google Scholar 

  122. King, C. R., Shinohara, T. and Piatigorsky, J., 1982. Science 215: 985–987.

    Google Scholar 

  123. Yasuda, K., Kondoh, H., Okazaki, K., Shimura, Y. and Okada, T. S., 1982. Fifth Int. Cong. Eye Res., Abstract Book p. 38, Eindhoven, The Netherlands.

  124. Benedetti, E. L., Zweers, A. and Bloemendal, H., 1968. Biochem. J. 108: 765–770.

    Google Scholar 

  125. Zelenka, P. and Piatigorsky, J., 1976. J. Biol. Chem. 251: 4294–4298.

    Google Scholar 

  126. Kohne, D. E., 1970. Quarterly Rev. Biophys. 3: 327–375.

    Google Scholar 

  127. Southern, E. M., 1975. J. Mol. Biol. 98: 503–517.

    Google Scholar 

  128. Bhat, S. P., Jones, R. E., Sullivan, M. A. and Piatigorsky, J., 1980. Nature 284: 234–238.

    Google Scholar 

  129. Jones, R. E., Bhat, S. P., Sullivan, M. and Piatigorsky, J., 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 5879–5883.

    Google Scholar 

  130. Naora, H. and Deacon, N. J., 1982. Proc. Natl. Acad. Sci. U.S.A. 79: 6196–6200.

    Google Scholar 

  131. Gilbert, W., 1978. Nature 271: 501.

    Google Scholar 

  132. Gilbert, W., 1979. Eucaryotic Gene Regulation, ICN-UCLA Symposia on Molecular and Cellular Biology (Axel, R., Maniatis, T. and Fox, C. F. eds.), Vol. 14, pp. 1–12, Academic Press, Inc., New York.

  133. Blake, C. C. F., 1978. Nature 273: 267.

    Google Scholar 

  134. Tonegawa, S., Maxam, A. M., Tizaard, R., Bernard, O. and Gilbert, W., 1978. Proc. Natl. Acad. Sci. U.S.A. 75: 1485–1489.

    Google Scholar 

  135. Sakano, H., Rogers, J. H., Huppi, K., Brack, C., Traunecker, A., Maki, R., Wall, R. and Tonegawa, S., 1979. Nature 277: 627–633.

    Google Scholar 

  136. Tilghman, S. M., Tiemeier, D. C., Seidman, J. G., Peterlin, B. M., Sullivan, M., Maizel, J. V. and Leder, P., 1978. Proc. Nad. Acad. Sci. U.S.A. 75: 725–729.

    Google Scholar 

  137. Jeffreys, A. J. and Flavell, R. A., 1977. Cell 12: 1097–1108.

    Google Scholar 

  138. Leder, A., Miller, H. I., Hamer, D. H., Seidman, J. G., Norman, B., Sullivan, M. and Leder, P., 1978. Proc. Natl. Acad. Sci. U.S.A. 75: 6187–6191.

    Google Scholar 

  139. Craik, C. S., Buchman, S. R. and Beychok, S., 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 1384–1388.

    Google Scholar 

  140. Eaton, W. A., 1980. Nature 284: 183–185.

    Google Scholar 

  141. Go, M., 1981. Nature 291: 90–92.

    Google Scholar 

  142. Stein, J. P., Catterall, J. F., Kristo, P., Means, A. R. and O'Malley, B. W., 1980. Cell 21: 681–687.

    Google Scholar 

  143. Jones, R. E., DeFeo, D. and Piatigorsky, J., 1981. J. Biol. Chem. 256: 8172–8176.

    Google Scholar 

  144. Garfin, D. E. and Goodman, H. E., 1974. Biochem. Biophys. Res. Commun. 59: 108–116.

    Google Scholar 

  145. Mann, M. B. and Smith, H. O., 1977. Nucleic Acids Res. 4: 4211–4221.

    Google Scholar 

  146. Jones, R. E., DeFeo, D. and Piatigorsky, J., 1981. Vision Res. 21: 5–9.

    Google Scholar 

  147. Razin, A. and Riggs, A. D., 1980. Science 210: 604–610.

    Google Scholar 

  148. Ehrlich, M. and Wang, R. Y.-H., 1981. Science 212: 1350–1357.

    Google Scholar 

  149. Jahner, D., Stuhlmann, H., Stewart, C. L., Harbers, K., Lohler, J., Simon, I. and Jaenisch, R., 1982. Nature 298: 623–628.

    Google Scholar 

  150. van der Ploeg, L. H. T. and Flavell, R. A., 1980. Cell 19: 947–958.

    Google Scholar 

  151. Wilks, A. F., Cozens, P. J., Mattaj, I. W. and Jost, J.-P., 1982. Proc. Natl. Acad. Sci. U.S.A. 79: 4252–4255.

    Google Scholar 

  152. McKeon, C., Ohkubo, H., Pastan, I. and de Crombrugghe, B., 1982. Cell 29: 203–210.

    Google Scholar 

  153. Hjelle, B., Phillips, III, J. A. and Seeburg, P. H., 1982. Nucleic Acids Res. 10: 3459–3474.

    Google Scholar 

  154. Errington, L. H., Cooper, D. N. and Clayton, R. M., 1983. Differentiation 24: 33–38.

    Google Scholar 

  155. Bower, D. J., Errington, L. H., Cooper, D. N., Morris, S. and Clayton, R. M., 1983. Nucleic Acids Res. 11: 2513–2527.

    Google Scholar 

  156. Bower, D. J., Pollock, B. J. and Clayton, R. M., 1982. Stability and Switching in Cellular Differentiation (Clayton, R. M. and Truman, D. E. S., eds.), pp. 445–450, Plenum Press, New York and London.

  157. Bower, D. J., Errington, L. H., Pollock, B. J., Morris, S. and Clayton, R. M., 1983. EMBO 2: 333–338.

    Google Scholar 

  158. Shinohara, T. and Piatigorsky, J., 1976. Proc. Natl. Acad. Sci. U.S.A. 73: 2808–2812.

    Google Scholar 

  159. Milstone, L. M., Zelenka, P. and Piatigorsky, J., 1976. Develop. Biol. 48: 197–204.

    Google Scholar 

  160. Katoh, A. and Yoshida, K., 1973. Exp. Eye Res. 15: 353–360.

    Google Scholar 

  161. Zwaan, J., 1974. Wilhelm Roux Arch. Entwicklungsmech. Org. 175: 13–25.

    Google Scholar 

  162. Yoshida, K. and Katoh, A., 1971. Exp. Eye Res. 11: 184–194.

    Google Scholar 

  163. Milstone, L. M. and Piatigorsky, J., 1975. Develop. Biol. 43: 91–100.

    Google Scholar 

  164. Beebe, D. C. and Piatigorsky, J., 1981. Develop. Biol. 84: 96–101.

    Google Scholar 

  165. Bagchi, M., Alcala, J. R. and Maisel, H., 1981. Exp. Eye Res. 32: 251–254.

    Google Scholar 

  166. Bagchi, M., Maisel, H. and Ellis, M., 1982. Exp. Eye Res. 35: 325–329.

    Google Scholar 

  167. Treton, J. A., Shinohara, T. and Piatigorsky, J., 1982. Develop. Biol. 92: 60–65.

    Google Scholar 

  168. Kondoh, H., Yasuda, K. and Okada, T. S., 1983. Nature 301: 440–442.

    Google Scholar 

  169. Shinohara, T. and Piatigorsky, J., 1977. Nature 270: 406–411.

    Google Scholar 

  170. Manski, W. and Halbert, S. P., 1965. Invest. Ophthalmol. 4: 539–559.

    Google Scholar 

  171. Rabaey, M., 1968. Biochemistry of the Eye, Symp. Tutzing Castle, Aug. 1966, pp. 301–315, Karger, Basel, New York.

    Google Scholar 

  172. Gysels, H., 1965. J. Ornith. 106: 206–217.

    Google Scholar 

  173. Gysels, H., 1974. Experientia 30: 1253–1254.

    Google Scholar 

  174. Ingolia, T. D. and Craig, E. A., 1982. Proc. Natl. Acad. Sci. U.S.A. 79: 2360–2364.

    Google Scholar 

  175. Wistow, G., Slingsby, C., Blundell, T., Driessen, H., de Jong, W. and Bloemendal, H., 1981. FEBS Lett. 133: 9–16.

    Google Scholar 

  176. Dayhoff, M., 1972. Atlas of Protein Sequence and Structure, Vol. 5, National Biomedical Research Foundation, Washington DC.

    Google Scholar 

  177. Cornish-Bowden, A., 1979. J. Theor. Biol. 76: 369–386.

    Google Scholar 

  178. Messing, J., Crea, R. and Seebury, P. H., 1981. Nucleic Acids Res. 9: 309–321.

    Google Scholar 

  179. Sanger, F., Nicklen, S. and Coulson, A. R., 1977. Proc. Nall. Acad. Sci. U.S.A. 74: 5463–5467.

    Google Scholar 

  180. Richardson, W. D., Carter, B. J. and Westphal, H., 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 931–935.

    Google Scholar 

  181. Richardson, W. D. and Westphal, H., 1981. Cell 27: 133–141.

    Google Scholar 

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  1. Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, 20205, Bethesda, MD, USA

    Joram Piatigorsky

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Piatigorsky, J. Delta crystallins and their nucleic acids. Mol Cell Biochem 59, 33–56 (1984). https://doi.org/10.1007/BF00231304

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  • DOI: https://doi.org/10.1007/BF00231304

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