Abstract
Concentrations of lead, cadmium, methylmercury and total mercury were measured in maternal and umbilical cord blood using graphite atomic absorption spectrometry. Two essential metals, copper and zinc, were also determined using ion chromatography. Lead, copper and zinc were found to be lower in the cord blood, whereas methylmercury and total mercury were higher in cord blood than in maternal blood. Little differences were noted for cadmium in maternal and cord blood. Significant positive correlations were observed between the concentrations in maternal and cord blood with regard to lead (correlation coefficient, r = 0.44), copper (r = 0.34), zinc (r = 0.29), methylmercury (r = 0.44) and total mercury (r = 0.58). These results suggest that, like essential metals, most heavy metals can move rather freely across the human placenta. The potential health effects of heavy metal transfer from mothers to young infants cannot be discounted.
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References
Ahokas RA, Ditls PV. 1985 Cadmium uptake by the rat embryo as a function of gestational age. Am J Obstret Gynecol 135, 219–222.
Barltrop D. 1989 Mineral Metabolism in Paediatrics. London: Blackwells.
Chia KS, Ong CN, Ong HY, Endo G. 1989 Renal tubular function of workers exposed to low levels of cadmium. Br J Ind Med 46, 165–170.
Commision of the European Communities. 1990 Trace Element Reference Values in Tissues from Inhabitants of the European Community. Joint Research Centre.
Davis JM, Svendsgaard DJ. 1987 Lead and child development. Nature 329, 297–300.
Foo SC, Ngim CH, Phoon WO, Lee J. 1988 Mercury levels of healthy Singapore residents. Sci Total Environ 72, 112–122.
Kyle JH, Ghani N. 1983 Mercury concentrations in canned and fresh fish and its accumulation in a population of Port Moresby residents. Sci Total Environ 26, 157–163.
Miller RK. 1984 Perinatal toxicology: its recognition and fundamentals. Am J Ind Med 4, 205–244.
Needleman HL. 1988 The persistent threat of lead: medical and social issue. Curr Probl Pediat 18, 197–244.
Ng TP, Goh HH, Ng YL, Ong HY, Ong CN, Chia KS, Jeyaratnam J. 1991 Male endocrine functions in workers with moderate exposure to lead. Br J Ind Med 48, 485–491.
Ngim CH, Foo SC, Phoon WO. 1989 Atomic absorption spectrophotometric microdetermination of total mercury in undigested biological specimens. J Anal Toxicol 12, 132–135.
Ong CN, Lee WR. 1980 High affinity of lead for foetal haemoglobin. Br J Ind Med 38, 254–260.
Ong CN, Phoon WO, Law HY, Tye CY, Lim HH. 1985 Concentrations of lead in maternal blood, cord blood and breast milk. Arch Dis Child 60, 756–759.
Ong CN, Ong HY, Chua LH. 1988 Determination of copper and zinc in serum and whole blood by ion chromatography. Anal Biochem 173, 64–69.
Rabinowitz MB, Needleman HL. 1982 Temporal trends in the lead concentrations of umbilical cord blood. Science 216, 1429–1431.
Soong YJ, Tseng R, Liu C, Lin PW. 1991 Lead, cadmium and mercury levels in maternal and fetal cord blood. Taiwan I Hsueh Tsa Chih 190, 59–65.
Tsuchiya H, Mitani K, Kodama K, Nakata T. 1984 Placenta transfer of heavy metals in normal pregnant Japanese women. Arch Environ Hlth 39, 11–15.
Vir SC, Lone A, Thomson W. 1981 Serum and hair concentrations of copper during pregnancy. Am J Clin Nutr 34, 2328–2338.
Zaembski PM, Griffiths PD, Walker J, Goodall HB. 1983 Lead in neonates and mothers. Clin Chem Acta 134, 35–49.
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Ong, C.N., Chia, S.E., Foo, S.C. et al. Concentrations of heavy metals in maternal and umbilical cord blood. Biometals 6, 61–66 (1993). https://doi.org/10.1007/BF00154234
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DOI: https://doi.org/10.1007/BF00154234