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Recent advances in neural interfaces—Materials chemistry to clinical translation

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Abstract

Implantable neural interfaces are important tools to accelerate neuroscience research and translate clinical neurotechnologies. The promise of a bidirectional communication link between the nervous system of humans and computers is compelling, yet important materials challenges must be first addressed to improve the reliability of implantable neural interfaces. This perspective highlights recent progress and challenges related to arguably two of the most common failure modes for implantable neural interfaces: (1) compromised barrier layers and packaging leading to failure of electronic components; (2) encapsulation and rejection of the implant due to injurious tissue-biomaterials interactions, which erode the quality and bandwidth of signals across the biology-technology interface. Innovative materials and device design concepts could address these failure modes to improve device performance and broaden the translational prospects of neural interfaces. A brief overview of contemporary neural interfaces is presented and followed by recent progress in chemistry, materials, and fabrication techniques to improve in vivo reliability, including novel barrier materials and harmonizing the various incongruences of the tissue-device interface. Challenges and opportunities related to the clinical translation of neural interfaces are also discussed.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, and Department of Biomedical Engineering, Carnegie Mellon University, USA

    Christopher J. Bettinger

  2. Department of Biomedical Engineering, University of North Texas, USA

    Melanie Ecker

  3. Department of Bioengineering, University of Pittsburgh, USA

    Takashi Daniel Yoshida Kozai

  4. University of Cambridge, UK

    George G. Malliaras

  5. Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, USA

    Ellis Meng

  6. Department of Mechanical Engineering, The University of Texas at Dallas, USA

    Walter Voit

Authors
  1. Christopher J. Bettinger
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  2. Melanie Ecker
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  3. Takashi Daniel Yoshida Kozai
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  4. George G. Malliaras
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  5. Ellis Meng
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  6. Walter Voit
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Additional information

This article is based on the Materials Research Society/Kavli Future of Materials workshop: Brain-Machine Interfaces: Materials to Clinical Translation, presented at the 2019 MRS Spring Meeting in Phoenix, Ariz.

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Bettinger, C.J., Ecker, M., Kozai, T.D.Y. et al. Recent advances in neural interfaces—Materials chemistry to clinical translation. MRS Bulletin 45, 655–668 (2020). https://doi.org/10.1557/mrs.2020.195

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  • DOI: https://doi.org/10.1557/mrs.2020.195

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