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Biomimetic Approaches Towards Device-Tissue Integration

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Handbook of Neuroengineering

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Abstract

The application of biomimetic technologies to neural interfaces seeks to improve the long-term safety and performance of implantable systems. These biomimetic approaches encompass methods that alter the biological environment through mechanical, topographical and biological approaches. This chapter examines recent developments in bioinspired soft and functional materials designed for neural interfaces and their application to neuroprosthetic devices. Further approaches to engineering the neural interface, such as the application of tissue engineering and genetic engineering technologies, including their role in the development of next-generation neuroprosthetic devices are assessed.

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Abbreviations

3D:

Three Dimensional

Ascl1:

Achaete-Scute Homolog 1

AV8:

Adeno-Associated Viral Vector

AVV2:

Adeno-Associated Viral Vector

BAC:

Bacterial Artificial Chromosome

Brn2:

Bearskin 2

ChR2:

Channelrhodopsin2

CHs:

Conducting Hydrogels

CNS:

Central Nervous System

CPs:

Conducting Polymers

DCX+ :

Doublecortin

Dlx2:

Distal-Less Homeobox 2

ECM:

Extracellular Matrix

EL222:

Erythrobacter Litoralis Protein

GAGs:

Glycosaminoglycans

GABA:

Gamma-Aminobutyric Acid

GFAP:

Anti-Glial Fibrillary Acidic Protein

GFP:

Green Fluorescent Protein

LED:

Light Emitting Diode

Myt1l:

Myelin Transcription Factor 1-Like

NeuroD1:

Neuronal Differentiation 1

Neurog2:

Neurogenin-2

Pax6:

Paired Box Protein-6

PBS:

Phosphate-Buffered Saline Solution

Pt:

Platinum

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Authors and Affiliations

  1. Department of Bioengineering, Imperial College London, London, UK

    Catalina Vallejo-Giraldo, Martina Genta, Josef Goding & Rylie Green

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  1. Catalina Vallejo-Giraldo
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  2. Martina Genta
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  3. Josef Goding
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  4. Rylie Green
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Correspondence to Rylie Green .

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  1. Neuroengineering and Biomedical Instrumentation Laboratory Department of Biomedical Engineering and Department of Electrical and Computer Engineering, Neurology, Johns Hopkins University, Baltimore, MD, USA

    Nitish V. Thakor

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Vallejo-Giraldo, C., Genta, M., Goding, J., Green, R. (2023). Biomimetic Approaches Towards Device-Tissue Integration. In: Thakor, N.V. (eds) Handbook of Neuroengineering. Springer, Singapore. https://doi.org/10.1007/978-981-16-5540-1_97

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