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Aryl-Hydrocarbon Receptor as a Potential Target for Anticancer Therapy

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Abstract—Aryl-hydrocarbon receptor (Aryl Hydrocarbon Receptor, AHR) is a ligand-dependent transcription factor; its functions are related to xenobiotic detoxification, response to inflammation, and the maintenance of tissue homeostasis. Results of recent studies suggest that AHR also plays an important role in carcinogenesis. Increased expression of AHR is observed in several types of tumors and tumor derived cell lines. In addition, many AHR ligands are included in compositions of pharmaceutical drugs used in oncotherapy. These facts provide some ground to consider AHR as a potential target for anticancer therapy, especially for treatment of severe cancers which have very limited (if any) treatment options. In this review we have considered the examples of the effects of AHR ligands on tumor derived cell cultures and on model mice lines with analysis of the AHR-dependent response.

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  1. Koltzov Institute of Developmental Biology of Russian Academy of Sciences (IDB RAS), ul. Vavilova 26, 119334, Moscow, Russia

    J. E. Vorontsova, R. O. Cherezov, B. A. Kuzin & O. B. Simonova

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Vorontsova, J.E., Cherezov, R.O., Kuzin, B.A. et al. Aryl-Hydrocarbon Receptor as a Potential Target for Anticancer Therapy. Biochem. Moscow Suppl. Ser. B 13, 36–54 (2019). https://doi.org/10.1134/S1990750819010116

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