Abstract
Receptor tyrosine kinase IRR is a pH-sensor that able to be activated by alkaline extracellular media. IRR is a close homologue of the insulin receptor and insulin-like growth factor receptor but no endogenous ligands of a peptide or protein nature have been found for IRR. IRR expression was detected in certain populations of kidney cells, stomach, pancreas and also in parts of the sympathetic and cholinergic neurons. We have previously identified behavioral disorders in mice lacking IRR. In this study we performed a comparative analysis of wild-type mice brain transcriptomes and IRR-knockout mice brain transcriptomes using method of deep sequencing. The most significant difference (two-fold increase in expression) was observed for Ly6/PLAUR protein transcript. It is known that this protein is able to stimulate nicotinic acetylcholine receptor desensibilization. These results suggest that behavioral characteristics of mice lacking IRR are caused by the functional link between IRR and Ly6/PLAUR in cholinergic neurons of the brain.
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Abbreviations
- IRR:
-
insulin receptor-related receptor
- GPI:
-
glycosylphosphatidylinositol
- SPF:
-
sterile zone keeping animals
References
Tatulian, S.A., Biochemistry, 2015, vol. 54, pp. 5523–5532.
Shier, P. and Watt, V.M., J. Biol. Chem., 1989, vol. 264, pp. 14605–14608.
Dissen, G.A., Garcia-Rudaz, C., Tapia, V., Parada, L.F., Hsu, S.Y., and Ojeda, S.R., Endocrinology, 2006, vol. 147, pp. 155–14608.
Deev, I.E., Vasilenko, K.P., Kurmangaliev, E.Z., Serova, O.V., Popova, N.V., Galagan, Y.S., Burova, E.B., Zozulya, S.A., Nikol’skii, N.N., and Petrenko, A.G., Dokl. Biochem. Biophys., 2006, vol. 408, pp. 184–187.
Deyev, I.E., Sohet, F., Vassilenko, K.P., Serova, O.V., Popova, N.V., Zozulya, S.A., Burova, E.B., Houillier, P., Rzhevsky, D.I., Berchatova, A.A., Murashev, A.N., Chugunov, A.O., Efremov, R.G., Nikol’sky, N.N., Bertelli, E., Eladari, D., and Petrenko, A.G., Cell Metab., 2011, vol. 13, pp. 679–689.
Hirayama, I., Tamemoto, H., Yokota, H., Kubo, S.K., Wang, J., Kuwano, H., Nagamachi, Y., Takeuchi, T., and Izumi, T., Diabetes, 1999, vol. 48, pp. 1237–1244.
Mathi, S.K., Chan, J., and Watt, V.M., Endocrinology, 1995, vol. 136, pp. 4125–4132.
Reinhardt, R.R., Chin, E., Zhang, B., Roth, R.A., and Bondy, C.A., J. Neurosci., 1994, vol. 14, pp. 4674–4683.
Reinhardt, R.R., Chin, E., Zhang, B., Roth, R.A., and Bondy, C.A., Endocrinology, 1993, vol. 133, pp. 3–10.
Orlov, R.S. and Nozdrachev, A.D., Normal’naya fiziologiya (Normal Physiology), GEOTAR-Media, 2005.
Deyev, I.E., Mitrofanova, A.V., Zhevlenev, E.S., Radionov, N., Berchatova, A.A., Popova, N.V., Serova, O.V., and Petrenko, A.G., J. Biol. Chem., 2013, vol. 288, pp. 33884–33893.
Deyev, I.E., Chachina, N.A., Shayahmetova, D.M., Serova, O.V., and Petrenko, A.G., Biochimie, 2015, vol. 111, pp. 1–9.
Zubkov, E.A., Morozova, A.Yu., Chachina, N.A., Shayakhmetova, D.M., Deyev, I.E., and Petrenko, A.G., Zh. Vyssh. Nervn. Deyat. im. I.P. Pavlova, 2016 (in press).
Daehwan, K., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., and Salzberg, S.L., Genome Biol., 2014, vol. 4, p. 36.
Anders, S. and Huber, W., Heidelberg, Germany: European Molecular Biology Laboratory (EMBL), 2012.
Aronesty, E., Expression Analysis, Durham, NC. http://www.code.google.com/p/ea-utils, 2011
Dodt, M., Roehr, J.T., Ahmed, R., and Dieterich, C., MDPI Biol., 2012, vol. 1, pp. 895–905.
www.bioinformatics.bbsrc.ac.uk/projects/fastqc
Ibanez-Tallon, I., Miwa, J.M., Wang, H.-L., Adams, N.C., Crabtree, G.W., Sine, S.M., and Heintz, N., Neuron, 2002, vol. 33, pp. 893–903.
Chen, D. and Patrick, J.W., J. Biol. Chem., 1997, vol. 272, pp. 24024–24029.
Ohno, M., Menez, R., Ogawa, T., Danse, J.M., Shimohigashi, Y., Fromen, C., Ducancel, F., Zinn-Justin, S., Le Du, M.H., Boulain, J.C., Tamiya, T., and Menez, A., Prog. Nucleic Acids, 1998, vol. 59, pp. 307–364.
Chang, L.S., Chou, Y.C., Lin, S.R., Wu, B.N., Lin, J., Hong, E., Sun, Y.J., and Hsiao, C.D., J. Biochem., 1997, vol. 122, pp. 1252–1259.
Chang, L.S., Lin, J., Chou, Y., and Hong, E., Biochem. Biophys. Res. Commun., 1997, vol. 239, pp. 756–762.
Miwa, J.M., Ibanez-Tallon, I., Crabtree, G.W., Sanchez, R., Sali, A., Role, L.W., and Heintz, N., Neuron, 1999, vol. 23, pp. 105–114.
Dessaud, E., Salaun, D., Gayet, O., Chabbert, M., and de Lapeyrierea, O., Mol. Cell. Neurosci., 2006, vol. 32, pp. 232–242.
Rogers, S.W., Gahring, L.C., Collins, A.C., and Marks, M., J. Neurosci., 1998, vol. 18, pp. 4825–4832.
Miwa, J.M., Lester, H.A., and Walz, A., Physiology, 2012, vol. 27, pp. 187–199.
Tekinay, A.B., Nong, Y., Miwa, J.M., Lieberam, I., Ibanez-Tallon, I., Greengard, P., and Heintz, N., Proc. Natl. Acad. Sci. U. S. A., 2009, vol. 106, pp. 4477–4482.
Kitamura, T., Kido, Y., Nef, S., Merenmies, J., Parada, L.F., and Accili, D., Mol. Cell Biol., 2001, vol. 2116, pp. 5624–5630.
Spijker, S., Neuromethods, 2011, vol. 57, pp. 13–26.
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The article was translated by the authors.
Original Russian Text © D.M. Shayahmetova, E.S. Zhevlenev, A.A. Mozhaev, I.E. Deyev, A.G. Petrenko, 2016, published in Bioorganicheskaya Khimiya, 2016, Vol. 42, No. 4, pp. 496–500.
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Shayahmetova, D.M., Zhevlenev, E.S., Mozhaev, A.A. et al. Genetic link between IRR-receptor and Ly6/PLAUR protein. Russ J Bioorg Chem 42, 449–452 (2016). https://doi.org/10.1134/S1068162016040166
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DOI: https://doi.org/10.1134/S1068162016040166