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Amphiphilic alginate as a drug release vehicle for water-insoluble drugs

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Abstract

A preliminary study on the hydrophobic modified alginate (HM-alginate) as the drug delivery system for the model water-insoluble drugs, clofazimine and Amphotericin B was performed. It was found that HM-alginate can significantly increase the solubilities of these two drugs. The apparent water solubilities of clofazimine and Amphotericin B increased up to 1100 and 160 times, respectively, in aqueous solutions containing HM-alginate. The presence of sodium chloride in polymer solution decreased the solubilities of the drugs, compared to the salt-free solutions. HM-alginate also exhibited excellent sustained release effect, which increased with concentration. The type of HM-alginate, which we used herein, might have potential applications as water-insoluble drug delivery carrier.

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Authors and Affiliations

  1. State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, P. R. China

    Yang Meng, Jiaxing Zhang, Qimeng Cao, Qingbing Liu & Yueqin Yu

  2. College of Materials Science and Engineering, Chongqing University, Chongqing, 400044, P. R. China

    Chenyu Wu

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  1. Yang Meng
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  2. Chenyu Wu
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  3. Jiaxing Zhang
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  4. Qimeng Cao
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  5. Qingbing Liu
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  6. Yueqin Yu
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Correspondence to Yueqin Yu.

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Meng, Y., Wu, C., Zhang, J. et al. Amphiphilic alginate as a drug release vehicle for water-insoluble drugs. Colloid J 77, 754–760 (2015). https://doi.org/10.1134/S1061933X15060149

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  • DOI: https://doi.org/10.1134/S1061933X15060149

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