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Bile salts: unlocking the potential as bio-surfactant for enhanced drug absorption

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Abstract

In the pursuit of developing new active ingredients for drug development, bile salts have emerged as promising substances that can enhance absorption. Their unique properties, characterized by being both hydrophilic and hydrophobic, provide numerous opportunities for modifying drugs across different categories. As naturally occurring surfactants within the body, bile salts have been extensively utilized to improve the absorption of drugs through various biological barriers, including the blood–brain barrier, skin, mucosa, cornea, buccal (oral cavity), nasal, pulmonary (lung), and intestinal membranes. By leveraging bile salts, researchers have discovered their significant potential in increasing drug permeability and bioavailability by facilitating transport through these barriers. Additionally, bile salts can be effectively combined with other commonly used materials in drug delivery, such as lipids and polymers, expanding their application as active ingredients. This comprehensive review aims to present the latest insights in this field by examining recent literature on the subject.

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  1. Pidugu Shivaji Ashok Chakravarthy and Pankaj Popli contributed equally.

Authors and Affiliations

  1. Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India

    Pidugu Shivaji Ashok Chakravarthy, Pankaj Popli, Inderbir Singh & Rajan Swami

  2. Department of Pharmacy, Jagannath University, Bahadurgarh, Haryana, India

    Pankaj Popli

  3. Formulation and development, Quotient Sciences, 3080 McCann Farm Dr, Garnet Valley, PA, USA

    Ranadheer Reddy Challa

  4. Odin Pharmaceutical LLC, Somerset, NJ, USA

    Bhaskar Vallamkonda

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  1. Pidugu Shivaji Ashok Chakravarthy
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Chakravarthy, P.S.A., Popli, P., Challa, R.R. et al. Bile salts: unlocking the potential as bio-surfactant for enhanced drug absorption. J Nanopart Res 26, 76 (2024). https://doi.org/10.1007/s11051-024-05985-6

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